Publications by authors named "Bingzheng Chen"
Article Synopsis
- Methamphetamine (MA) abuse leads to serious cardiovascular issues, making myocardial injury and oxidative stress key concerns, with the Nrf2 pathway playing a crucial role in these processes.
- In an experiment, MA was administered to mice, resulting in significant increases in markers of cardiac injury and oxidative stress, highlighting the harmful effects of MA on the heart.
- Activation of the Nrf2 pathway reduced the damage caused by MA, while knocking out Nrf2 worsened the injury, indicating that Nrf2 has a protective role against MA-induced heart damage.
Methamphetamine (MA) is a widely abused drug that can cause kidney damage. However, the molecular mechanism remains unclear. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor that regulates resistance to oxidative and proteotoxic stress.
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- Methamphetamine (METH) abuse has rapidly increased in recent years, leading to severe addiction and neurotoxicity, with no approved treatments currently available.
- Cannabidiol (CBD), a non-psychoactive compound from cannabis, shows promise in protecting against METH's harmful effects by counteracting neurotoxic mechanisms, though its exact action is still unclear.
- Research indicates that CBD and METH may bind to the dopamine receptor D1 (DRD1), with CBD potentially blocking METH's damaging impacts on cell signaling and apoptosis, offering insight into a possible therapeutic strategy for METH use disorders.