Primary osteosarcoma of the kidney: A case report.

Primary renal osteosarcoma is an exceedingly rare subtype of renal malignancy, noted for its aggressive nature and often fatal outcome. The scarcity and severity of this condition have resulted in a dearth of reliable methods for early diagnosis and effective treatment. The present article contributes to the existing body of knowledge by presenting a comprehensive clinical case of a 46-year-old male patient with primary renal osteosarcoma.

Construction and validation of a prediction model for inguinal lymph node metastasis of penile malignancy.

Background: Penile squamous cell carcinoma is a relatively rare malignancy among male malignancies, there are more than 30,000 new cases and more than 10,000 deaths of penile cancer annually. In patients with penile malignancy, inguinal lymph node metastasis (ILNM) significantly reduces patient survival. Thus, we identified the risk factors for ILNM in penile malignancies, aiming to develop a precise prediction model.

Identification of prostate cancer bone metastasis related genes and potential therapy targets by bioinformatics and in vitro experiments.

The aetiology of bone metastasis in prostate cancer (PCa) remains unclear. This study aims to identify hub genes involved in this process. We utilized machine learning, GO, KEGG, GSEA, Single-cell analysis, ROC methods to identify hub genes for bone metastasis in PCa using the TCGA and GEO databases.

Bioaccumulation mediated by water solubility leads to differences in the acute toxicity of organophosphorus insecticides to zebrafish (Danio rerio).

The use of some organophosphate insecticides is restricted or even banned in paddy fields due to their high toxicity to aquatic organisms. The aim of this study is to elucidate the main pathways and target organs of organophosphate insecticide toxicity to fish exposed via different routes by integrating histopathological and biochemical techniques. Using malathion as the model drug, when the dosage is 20-60 mg/L, the toxicity of whole body and head immersion drugs to zebrafish is much higher than that of trunk immersion drugs.

Mechanism of clay mineral modified biochar simultaneously immobilizes heavy metals and reduces soil carbon emissions.

Heavy metal pollution in farmland soil has become increasingly severe, and multi-element composite pollution has brought enormous harm to human production and life. Environmental changes in cold regions (such as freeze-thaw cycles and dry-wet alternations) may increase the potential physiological toxicity of heavy metals and exacerbate pollution risks. In order to reveal the effectiveness of sepiolite modified biochar in the remediation of the soil contaminated with lead (Pb), cadmium (Cd), and chromium (Cr), the rice husk biochar pyrolyzed at 500 and 800 °C were selected for remediation treatment (denoted as BC500 and BC800).

The boom era of emerging contaminants: A review of remediating agricultural soils by biochar.

Emerging contaminants (ECs) are widely sourced persistent pollutants that pose a significant threat to the environment and human health. Their footprint spans global ecosystems, making their remediation highly challenging. In recent years, a significant amount of literature has focused on the use of biochar for remediation of heavy metals and organic pollutants in soil and water environments.

Revised Tunable Q-Factor Wavelet Transform for EEG-Based Epileptic Seizure Detection.

Electroencephalogram (EEG) signals are an essential tool for the detection of epilepsy. Because of the complex time series and frequency features of EEG signals, traditional feature extraction methods have difficulty meeting the requirements of recognition performance. The tunable Q-factor wavelet transform (TQWT), which is a constant-Q transform that is easily invertible and modestly oversampled, has been successfully used for feature extraction of EEG signals.

Exposure of zebrafish (Danio rerio) to trans-2-hexenal induces oxidative stress and protein degeneration of the gill.

Trans-2-hexenal (T2H) has great commercial value for development as a biopesticide, but its toxicity risk to nontarget organisms is unknown. Here, the toxicity and underlying mechanism of T2H on zebrafish (Danio rerio) were investigated. The LC (48 h) of T2H on zebrafish is 4.

Toxicological differences of trifloxystrobin and kresoxim-methyl on zebrafish in various levels of exposure routes, organs, cells and biochemical indicators.

Trifloxystrobin (TRI) and kresoxim-methyl (KRE), as quinone outside inhibitor fungicides (QoIs), have broad applications due to their effective activity against fungi. Excessive usages of agrochemicals trigger environmental risks, such as aquatic organisms (fish). Research performed in recent years has focused on the ecotoxicology of TRI and KRE in fish containing histologic morphology, enzyme activity, protein and gene expression under chronic toxicity conditions, whereas less is known about the underlying mechanisms of toxicity and differences between TRI and KRE in fish under acute toxicity conditions.

Dual-signal amplification electrochemical sensing for the sensitive detection of uranyl ion based on gold nanoparticles and hybridization chain reaction-assisted synthesis of silver nanoclusters.

Herein, a dual-signal amplification electrochemical sensing has been proposed for the ultrasensitive detection of uranyl ions (UO) by integration of gold nanoparticles (AuNPs) and hybridization chain reaction (HCR)-assisted synthesis of silver nanoclusters (AgNCs). In this sensing platform, AuNPs are used as an ideal signal amplification carrier, aiming at increasing the loads of UO-specific DNAzyme on the gold electrode. In the presence of UO, UO-specific DNAzyme can be activated, leading to the cleavage of substrate strands (S-DNA).

Curcumin regulates EZH2/Wnt/β-Catenin pathway in the mandible and femur of ovariectomized osteoporosis rats.

Osteoporosis (OP) behaves in different manners in different parts of the skeleton. This study aims to investigate the effects of curcumin on bone mass of the mandibular and femur from ovariectomized OP rats and to validate whether enhancer of zeste homolog 2 (EZH2)/Wnt/β-Catenin pathway is involved in this process. Curcumin was administered intragastrically into ovariectomized rats for 12 weeks.

Estimation of Peanut Leaf Area Index from Unmanned Aerial Vehicle Multispectral Images.

Leaf area index (LAI) is used to predict crop yield, and unmanned aerial vehicles (UAVs) provide new ways to monitor LAI. In this study, we used a fixed-wing UAV with multispectral cameras for remote sensing monitoring. We conducted field experiments with two peanut varieties at different planting densities to estimate LAI from multispectral images and establish a high-precision LAI prediction model.

S-Vacancy induced indirect-to-direct band gap transition in multilayer MoS.

Two-dimensional (2D) MoS2 has various potential applications due to its attractive band gap of 1.29-1.90 eV and unique photoelectric properties.

Role of autophagy and apoptosis in atrophic epithelium in oral submucous fibrosis.

Oral submucous fibrosis (OSF) is a serious, potentially malignant oral disorder. It is histopathologically characterized by chronic inflammation and atrophic epithelium accompanied by the accumulation of collagen fibers in the lamina propria. The molecular mechanisms leading to atrophic epithelium remain poorly understood.

[Effects of curcumin on EZH2 mRNA expression in the mandible and femur of ovariectomized osteoporosis rats].

Purpose: To study the effects of curcumin on EZH2 mRNA expression in the mandible and femur of ovariectomized osteoporosis rats,and to investigate its protective effect and mechanism.

Methods: Thirty female 6-month old SD rats were randomly divided into sham group,OVX group and experimental group. The rats in the experimental groups were given curcumin (110 mg/kg) by intragastric administration after ovariectomy, while rats in the sham group and OVX group were given the same dosage of carboxymethylcellulose sodium solution, once a day for 12 weeks.

The push out bond strength of polydimethylsiloxane endodontic sealers to dentin.

Background: The purpose of this experiment was to assess the push out bond strength of Polydimethylsiloxane sealers (GuttaFlow 2 and GuttaFlow Bioseal by Colte'ne/Whaledent, Altstätten, Switzerland). AH Plus (Dentsply, DeTrey, Konstanz, Germany) was used as a reference material for comparison.

Methods: Thirty root slices were prepared from the middle third of 10 mandibular premolars.

Role of autophagy induced by arecoline in angiogenesis of oral submucous fibrosis.

Objectives: To detect the expression of protein light chain 3 (LC3) and p62-SQSTM1 (p62) in the lamina propria of oral submucous fibrosis (OSF) and to determine the association of autophagy with OSF. To investigate the role of autophagy in angiogenesis of human umbilical vein endothelial cells (HUVECs) and to assess whether this effect was induced by arecoline.

Methods: LC3 and p62 expression was detected in OSF tissue through immunohistochemistry (IHC).