Influence of Pavement Material and Structure on Low-Temperature Crack Resistance for Double-Layer Asphalt Surface One-Time Paving.

The double-layer one-time-paving technology for asphalt mixtures enhances the interlayer adhesion and stability of pavement by simultaneously laying and compacting two layers of asphalt mixture, demonstrating improvements over traditional layer-by-layer paving and compaction methods. Based on this technology, the effects of paving techniques, mixture types, and structural layer thickness on the low-temperature crack resistance of pavement at -10 °C were investigated. Results indicated that, compared to traditional paving methods, the maximum tensile strain and bending strain energy density of pavement using the double-layer one-time-paving technique increased by at least 14% and 20%, respectively, under a 95% confidence level.

Postoperative cognitive deficits and neuroinflammation in the hippocampus triggered by surgical trauma are exacerbated in aged rats.

Postoperative cognitive dysfunction (POCD) is characterized by the progressive deterioration of intellectual/cognitive function following surgery. It has been suggested that the senile brain, which characteristically expresses higher levels of central proinflammatory cytokines, interleukin (IL)-6, IL-1β, and tumor necrosis factor (TNF)-α, is more susceptible to additional insult following surgery. The authors of this study investigated the expression of central cytokines IL-1β, IL-6 and TNF-α and hippocampal glial cell activation in aged and adult rats following partial hepatectomy.