Publications by authors named "Bingyang Ji"
Background: The optimal temperature control strategy in extracorporeal cardiopulmonary resuscitation (ECPR) patients is unknown, and several trials have reported conflicting results regarding its effectiveness. We aimed to conduct a systemic review and network meta-analysis (NMA) to assess the efficacy of temperature control in ECPR patients.
Methods: Database searching of studies reporting data on temperature control strategy during ECPR in MEDLINE, EMBASE, Scopus, and Cochrane Library was performed.
Article Synopsis
- - The study focuses on comparing the effects of mild hypothermia and normothermia during coronary artery bypass grafting (CABG) with cardiopulmonary bypass (CPB) on postoperative bleeding and complications.
- - A total of 336 patients will be enrolled from September 2023 to December 2024 and randomly assigned to either a mild hypothermia group (32-33℃) or a normothermia group (35-36℃).
- - The primary outcome is measured by the Universal Definition of Perioperative Bleeding, while secondary outcomes include coagulation and inflammatory factors, complications, and lengths of stay in the ICU and hospital.
Background: The mortality and morbidity of emergency total aortic arch replacement (TAAR) for acute type A aortic dissection (ATAAD) is high, which is partly due to the excessively activated systemic inflammatory response. Methylprednisolone, an anti-inflammatory agent, might suppress the systemic inflammatory response and lead to improved outcomes. However, the protective effects of methylprednisolone on TAAR for ATAAD were not clarified.
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- Left ventricular (LV) overload is common in patients on VA-ECMO and is linked to poor outcomes, prompting a review of various LV unloading strategies.
- A network meta-analysis of 45 studies involving over 34,000 patients found that IABP and pLVAD significantly reduced all-cause mortality compared to no unloading, while also improving other outcomes like hospital stays.
- Although unloading strategies improved survival, they may increase the risk of complications, highlighting the need for careful consideration of these approaches.
Article Synopsis
- Factor XII (FXII) is crucial for activating the body's intrinsic coagulation pathway and has a previously unclear role in inflammation.
- Treating male mice with a novel antibody (Nb-Fc) that targets FXII significantly reduced arterial thrombosis without disrupting normal blood clotting.
- The study shows that inhibiting FXII can lower inflammation-related symptoms and complications during procedures like extracorporeal membrane oxygenation (ECMO), indicating its potential as a therapeutic target for thrombo-inflammatory diseases.
Human albumin solution for on-pump cardiac surgery: benefit or burden?
Intensive Care Med
November 2024
Risk Factors for Acute Kidney Injury in Adult Patients Under Veno-Arterial Extracorporeal Membrane Oxygenation Support.
J Cardiothorac Vasc Anesth
October 2024
Article Synopsis
- - The study examined the rates and risk factors for acute kidney injury (AKI) stage 3 in adults on veno-arterial extracorporeal membrane oxygenation (VA-ECMO) at Fuwai Hospital from January 2020 to December 2022.
- - A total of 40 patients (53.3%) experienced AKI stage 3, and these patients had a significantly higher in-hospital mortality rate compared to those with AKI stage <3 (67.5% vs 34.3%).
- - Key risk factors identified for AKI stage 3 included hypertension, low pre-ECMO hemoglobin levels, and elevated pre-ECMO lactate and creatinine levels, highlighting
Polypyrrole-coated sodium manganate microspheres cathode for superior performance Sodium-ion batteries.
J Colloid Interface Sci
November 2024
Article Synopsis
- P2-NaMnNiO is recognized as a cost-effective and non-toxic cathode material for sodium ion batteries, but it faces issues with cycling stability due to the Jahn-Teller effect and electrolyte decomposition.
- Researchers developed a composite, P2-NaNiMnO@PPy, by coating NNMO microspheres with conductive polypyrrole (PPy) to enhance performance, which was confirmed through various characterization techniques.
- The best performing composite, NNMO@PPy-9, exhibited impressive capacity retention and rate performance, alongside a full cell that achieved a high energy density and superior cycling stability, suggesting that PPy coatings could be a promising method to enhance sodium ion battery materials.
Objectives: The FUWAI-SAVE system is a modified low-priming cardiopulmonary bypass (CPB) system. The study aimed to explore whether the FUWAI-SAVE system can reduce the perioperative blood transfusion and its impact on other postoperative complications during cardiac surgery.
Metohds: This study was a single-center, single-blind, randomized controlled trial, registered at the Chinese Clinical Trial Registry (identifier: ChiCTR2100050488).
Article Synopsis
- Left ventricular assist devices (LVADs), particularly the CH-VAD, have become a key treatment for end-stage heart failure patients in China, with this study focusing on long-term outcomes.
- Fifty patients received the CH-VAD at Fuwai Hospital between June 2017 and August 2023, with a significant majority remaining on support for an average of 868 days and survival rates showing promising statistics at various intervals.
- The study found a low complication rate, with most patients experiencing manageable adverse events, leading to the conclusion that the CH-VAD is a safe and effective option for long-term heart failure management.
Article Synopsis
- The study aimed to develop a simple risk-prediction model to identify patients at risk of renal function decline after cardiac surgery, to improve follow-up efforts.
- An analysis of 24,904 patients indicated varying risks of kidney decline based on their estimated glomerular filtration rates (eGFR), with higher eGFR patients being at greater risk.
- The researchers created specific nomograms for each eGFR category, which showed strong predictive ability, helping to utilize routine data for better patient outcomes post-surgery.
Purpose: There is currently no consensus on the most appropriate blood transfusion strategy for older adults undergoing cardiovascular surgery. We aimed to investigate the potential benefits of the patient blood management (PBM) program specifically for advanced age patients, and to evaluate the relationship of age and PBM in cardiovascular surgery.
Patients And Methods: We collected data from patients over 60 years old who underwent on-pump cardiovascular surgery.
Article Synopsis
- This study explored how long-term awake ECMO impacts blood coagulation in sheep, involving ten healthy sheep divided into two groups: veno-arterial (V-A) ECMO and veno-venous (V-V) ECMO.
- After 7 days of being awake post-ECMO, both sheep groups had activated clotting times (ACT) around 250 seconds, with heparin doses increasing significantly to maintain this level.
- Results showed that the V-A ECMO group had notably higher activated partial thromboplastin time (APTT) and thrombin time (TT) than the V-V group, while kidney damage was observed in both groups despite normal lab results.
Septic shock, a global health concern, boasts high mortality rates. Research exploring the efficacy of venoarterial extracorporeal membrane oxygenation (VA-ECMO) in septic shock remains limited. Our study aimed to establish a rodent model employing VA-ECMO in septic shock rats, assessing the therapeutic impact of VA-ECMO on septic shock.
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- In on-pump cardiac surgery, using albumin for priming may help maintain better fluid balance compared to crystalloid solutions, but more quality research is needed to assess safety regarding blood transfusions.
- A network meta-analysis (NMA) was conducted to analyze available randomized controlled trials, focusing on intraoperative and early postoperative red blood cell transfusion volumes and postoperative blood loss.
- The results indicated that crystalloid priming significantly reduced total and intraoperative RBC transfusions compared to albumin, though postoperative transfusion trends leaned towards crystalloid, but were not statistically significant.
Article Synopsis
- This study investigated the relationship between preoperative AST/ALT ratio (a liver enzyme marker) and drainage volume after aortic arch surgery.
- A total of 425 patients were analyzed, and findings indicated that a higher AST/ALT ratio correlates with larger drainage volumes post-surgery.
- The results suggest that an elevated AST/ALT ratio could serve as an independent risk factor and potential marker for assessing cardiac surgery risks.
Sepsis is an unusual systemic reaction with high mortality and secondary septic liver injury is proposed to be the major cause of mortality. Extracorporeal membrane oxygenation (ECMO) can enhance terminal organ perfusion by elevating circulatory support which is used in severe sepsis patients. However, the interaction of blood components with the biomaterials of the extracorporeal membrane elicits a systemic inflammatory response.
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