Bisphenol AF induces lipid metabolism disorders, oxidative stress and upregulation of heat shock protein 70 in zebrafish.

Bisphenol AF (BPAF) is a widespread endocrine disruptor in the environment, and the use of BPAF has been strongly associated with the development of several diseases. In this study, we investigated the effects of BPAF on growth, development, oxidative stress and lipid metabolism in zebrafish. We chose the concentrations based on the measured LC at 96 h post-fertilization (96 hpf), and the zebrafish embryos were exposed to three different concentrations (0.

Drivers and spatial variations in the concentrations and limitations of carbon, nitrogen, and phosphorus in global alpine lakes.

Alpine lakes are highly sensitive to environmental changes and struggle to recover from disturbances. Global climate change and human activities increase carbon (C), nitrogen (N), and phosphorus (P) inputs to alpine lakes. In this study, we had conducted a comparative analysis of C, N, and P concentrations and their limitations for 323 alpine lakes with elevations ranging from 502 to 5,018 m a.

Transcriptome and Metabolome analysis reveal HFPO-TA induced disorders of hepatic glucose and lipid metabolism in rat by interfering with PPAR signaling pathway.

PFOA is one of the most representative compounds in the family of perfluorinated organic compounds. Due to its varying toxicity, alternatives to PFOA are beginning to emerge. HFPO-TA is an alternative for PFOA.

[Differences in uptake, utilization and loss of nitrogen and phosphorus in a Chinese double rice cropping system under different irrigation and fertilization managements].

In order to optimize water and fertilizer use in the double-cropping rice in eastern Fujian Province, a field runoff plot experiment was conducted to investigate rice yield, nutrient uptake, and runoff losses of N (nitrogen) and P (phosphorus) in the T(no chemical fertilization with traditional flooding irrigation), T(common chemical fertilizer of 273 kg N·hm, 59 kg P·hm, and 112 kg K·hm combined with traditional flooding irrigation), T(chemical fertilizer of 240 kg N·hm, 52 kg P·hm, and 198 kg K·hm combined with traditional flooding irrigation) and T(chemical fertilizer combined with shallow intermittent irrigation) treatments. Results showed that early rice grain yield in the T, T and T treatments significantly increased by 0.7, 1.

Computed Tomography-Guided Interstitial Brachytherapy for Locally Advanced Cervical Cancer: Introduction of the Technique and a Comparison of Dosimetry With Conventional Intracavitary Brachytherapy.

Objective: We present a new technique of 3-dimensional computed tomography-guided interstitial (IS) brachytherapy (BT) for locally advanced cervical cancer, offering a more advantageous clinical treatment approach.

Materials/methods: Interstitial BT was performed using an applicator combining uterine tandem and metal needles; needles were inserted freehand under real-time 3-dimensional computed tomography guidance. Twenty-eight patients with bulky tumors and/or parametrial extension (tumor size > 5 cm) after external beam radiotherapy received IS BT.

Salvage interstitial brachytherapy based on computed tomography for recurrent cervical cancer after radical hysterectomy and adjuvant radiation therapy: case presentations and introduction of the technique.

Purpose: Locally recurring cervical cancer after surgery and adjuvant radiotherapy remains a major therapeutic challenge. This paper presents a new therapeutic technique for such patients: interstitial brachytherapy (BT) guided by real-time three-dimensional (3D) computed tomography (CT).

Material And Methods: Sixteen patients with recurrent cervical cancer after radical surgery and adjuvant external-beam radiotherapy (EBRT) were included in this study.

Clinical feasibility of interstitial brachytherapy using a "hybrid" applicator combining uterine tandem and interstitial metal needles based on CT for locally advanced cervical cancer.

Purpose: To explore the dosimetric advantage of target volume and surrounding normal tissue by using interstitial (IS) brachytherapy (BT) based on three-dimensional CT in locally advanced cervical cancer, as a simple and effective clinical treatment approach.

Methods And Materials: Fifty-two patients with poor tumor response to external beam radiotherapy and a residual tumor >5 cm at the time of the first BT were included. IS BT was performed using a "hybrid" applicator combining uterine tandem and free metal needles based on three-dimensional CT.

LncRNA MALAT1 overexpression is an unfavorable prognostic factor in human cancer: evidence from a meta-analysis.

Long non-coding RNAs (lncRNAs) have been suggested to serve as an important role in tumor development and progression. The aim of this study was to analyse the association between lncRNA metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) and cancer patients' overall survival. We systematically and carefully searched the studies from electronic databases and seriously identified according to eligibility criteria.