Publications by authors named "Bingxu Xiu"
Article Synopsis
- Atherosclerosis (AS) is a chronic inflammatory disease where inflammation in the endothelial cells of arteries plays a crucial role in its progression.
- The study investigates how the calcium-sensing receptor (CaSR) influences this inflammation and finds that activating CaSR with the agonist NPS-R568 reduces atherosclerotic lesions and inflammation in mouse models.
- Additionally, the research reveals that CaSR helps control inflammation in human endothelial cells by downregulating integrin β1 and inhibiting NLRP3 inflammasome activation, indicating that targeting CaSR could be a promising approach for AS therapy.
