Publications by authors named "Bingxiang Shen"
As a psychoactive substance, ethanol is widely used in people's life. However, the neuronal mechanisms underlying its sedative effect remain unclear. In this study, we investigated the effects of ethanol on the lateral parabrachial nucleus (LPB), which is a novel component related to sedation.
View Article and Find Full Text PDFThe role of discoid domain receptor 1 on renal tubular epithelial pyroptosis in diabetic nephropathy.
Korean J Physiol Pharmacol
November 2022
Pyroptosis, a form of cell death associated with inflammation, is known to be involved in diabetic nephropathy (DN), and discoid domain receptor 1 (DDR1), an inflammatory regulatory protein, is reported to be associated with diabetes. However, the mechanism underlying DDR1 regulation and pyroptosis in DN remains unknown. We aimed to investigate the effect of DDR1 on renal tubular epithelial cell pyroptosis and the mechanism underlying DN.
View Article and Find Full Text PDFArticle Synopsis
- The outbreak of SARS-CoV-2 since late 2019 has led to a pneumonia epidemic affecting 236 countries, causing significant public health issues and multiple organ failures, particularly in critical patients.
- Previous coronaviruses, including SARS-CoV and MERS-CoV, have also shown a strong link to kidney damage in affected patients.
- This review focuses on summarizing the epidemiological and clinical features of these three pandemics, analyzing the mechanisms by which COVID-19 affects kidney health, and discussing the causes and prevention of secondary kidney diseases related to SARS-CoV-2.
Article Synopsis
- The study aimed to identify risk factors for medication nonadherence in patients with type 2 diabetes mellitus (T2DM) and create a nomogram model to predict this risk.
- A total of 338 T2DM patients were analyzed, revealing six independent risk factors: educational level, monthly income, drug affordability, number of medications, daily doses, and time spent taking them.
- The developed nomogram model accurately predicts nonadherence risk and was validated through bootstrapping, making it a useful tool for assessing medication adherence in T2DM patients.
A combination of selenium and polysaccharides: Promising therapeutic potential.
Carbohydr Polym
February 2019
Currently, selenium and polysaccharide combinations can be identified as three forms: natural selenium polysaccharides, synthetic selenium polysaccharides and selenium nanoparticles decorated with polysaccharides. Previous studies have indicated that these three combinations generally show better bioactivities, including immunomodulation, anti-tumour, antioxidation and glucose regulation, than those of either selenium or polysaccharides alone. Although they have not yet been developed as new drugs for clinical trials, results from previous studies have already shown their therapeutic potential for the future.
View Article and Find Full Text PDFExopolysaccharide from Trichoderma pseudokoningii promotes maturation of murine dendritic cells.
Int J Biol Macromol
November 2016
Dendritic cells (DCs) are the key regulators of immune responses. In this study, the effect of an exopolysaccharide (EPS) from the culture broth of Trichoderma pseudokoningii on the phenotypic and functional maturation of murine DCs and its underlying molecular mechanisms were investigated. It showed that EPS induced the morphological changes of DCs and the enhanced expression of DCs featured surface molecules CD11c, CD86, CD80 and major histocompatibility complex II (MHC-II).
View Article and Find Full Text PDFThe aim of this study was to examine the effect of extracellular polysaccharide (PEP) from Antarctic bacterium Pseudoaltermonas sp. S-5 on RAW 264.7 cells together with the underlying signaling pathways.
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