Publications by authors named "Bingshuo Shi"
Plasma metabolomic characteristics of atrial fibrillation patients with spontaneous echo contrast.
BMC Cardiovasc Disord
November 2024
Article Synopsis
- Patients with atrial fibrillation (AF) displaying spontaneous echo contrast (SEC) show signs of being in a prethrombic state, which can lead to thrombus formation.
- The study aimed to uncover the specific metabolic characteristics associated with SEC by analyzing metabolic pathways and identifying differential metabolites between SEC and non-SEC states.
- Findings revealed significant differences in metabolic patterns, with SEC patients showing a higher level of metabolic dysregulation in atrial plasma, which could help inform future therapeutic interventions and research directions for preventing thrombosis in AF patients.
Introduction: Pulmonary hypertension (PH) is highly prevalent in patients receiving dialysis. The precise mechanisms underlying PH in hemodialysis (HD) patients have not been adequately addressed. Emerging experimental evidence indicates that circulating fibrocytes may contribute significantly to this process.
View Article and Find Full Text PDFBackground: Cardiovascular disease (CVD) is the most common cause of mortality in end-stage renal disease (ESRD) patients. Fragmented QRS complex (fQRS) has been reported as a helpful marker in evaluating various cardiovascular pathologies. We aimed to investigate the value of the fQRS complex clinical decision of ESRD patients receiving dialysis.
View Article and Find Full Text PDFArticle Synopsis
- Lipopolysaccharide (LPS) triggers the expression of aconitate decarboxylase (IRG1) in macrophages, resulting in increased levels of the metabolite itaconate, but its specific effects on macrophage function are not fully understood.
- The researchers established that itaconate influences macrophage functions by affecting IL-1β secretion and iron metabolism, and confirmed these effects using IRG1 knockout THP-1 cell lines and various inhibitors.
- Their findings show that itaconate hampers the activity of aconitases, enzymes crucial for iron metabolism and IL-1β secretion, by damaging iron-sulfur clusters, highlighting the regulatory role of IRG1 and itacon