MRI T2 mapping and shear wave elastography for identifying main pain generator in delayed-onset muscle soreness: muscle or fascia?

Introduction: The main generator of delayed onset muscle soreness (DOMS) is still unknown. This study aimed to clarify the main generator of DOMS.

Methods: Twelve participants performed eccentric exercise (EE) on lower legs.

Intrinsic brain abnormalities in chronic rhinosinusitis associated with mood and cognitive function.

Background: Chronic rhinosinusitis (CRS) poses a risk for developing emotional and cognitive disorders. However, the neural evidence for this association is largely unclear. Resting-state functional magnetic resonance imaging (rs-fMRI) analysis can demonstrate abnormal brain activity and functional connectivity and contribute to explaining the potential pathophysiology of CRS-related mood and cognitive alterations.

Synthesis and high formaldehyde sensing properties of quasi two-dimensional mesoporous ZnSnO nanomaterials.

Quasi two-dimensional (2D) mesoporous ZnSnO nanomaterials (QTMZNS) were synthesized by a simple template-free hydrothermal method. The as-prepared products were characterized by TEM, SEM, XRD, TG/DTA, and FTIR. The results showed that the precursor was a mixture of Zn(OH)(CO) and ZnSnO in the hydrothermal process, and the high purity QTMZNS were obtained by calcination combined with subsequent washing of 20 wt% NHCl solutions.

Direct Macromolecular Drug Delivery to Cerebral Ischemia Area using Neutrophil-Mediated Nanoparticles.

Delivery of macromolecular drugs to the brain is impeded by the blood brain barrier. The recruitment of leukocytes to lesions in the brain, a typical feature of neuroinflammation response which occurs in cerebral ischemia, offers a unique opportunity to deliver drugs to inflammation sites in the brain. In the present study, cross-linked dendrigraft poly-L-lysine (DGL) nanoparticles containing cis-aconitic anhydride-modified catalase and modified with PGP, an endogenous tripeptide that acts as a ligand with high affinity to neutrophils, were developed to form the PGP-PEG-DGL/CAT-Aco system.