Publications by authors named "Bingrong Hong"
Article Synopsis
- Ionic liquid transdermal penetration enhancers (IL@TPEs) show promise in improving drug delivery through the skin, but there was a lack of scientific guidelines for designing effective ones.
- Researchers created novel biomimetic phospholipid-inspired IL@TPEs (PIL@TPEs) and discovered their effectiveness relies on the chemical properties of both drugs and cations involved in the formulation.
- The study revealed that PIL@TPEs behave differently than traditional enhancers, demonstrating strong interactions with drugs and skin, and ensuring safety through various biological tests.
Management of myocardial ischemia-reperfusion injury (MIRI) in reperfusion therapy remains a major obstacle in the field of cardiovascular disease, but current available therapies have not yet been achieved in mitigating myocardial injury due to the complex pathological mechanisms of MIRI. Exogenous delivery of hydrogen sulfide (HS) to the injured myocardium can be an effective strategy for treating MIRI due to the multiple physiologic functions of HS, including anti-inflammatory, anti-apoptotic, and mitochondrial protective effects. Here, to realize the precise delivery and release of HS, we proposed the targeted HS-mediated gas therapy with pH-sensitive release property mediated by platelet membranes (PMs).
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