Publications by authors named "Bingqiu Chen"
Sci Bull (Beijing)
November 2024
Article Synopsis
- KMT2D is a key methyltransferase linked to KABUKI syndrome, which causes various developmental issues, particularly in the brain and face.
- Researchers created a brain organoid model to study how KMT2D influences neural development and discovered that its loss leads to specific neural crest defects and increased production of certain brain cells.
- They identified the WNT3A enhancer as KMT2D's main target, showing that regulating this enhancer can help reverse developmental issues associated with KMT2D mutations, offering new insights into treating KABUKI syndrome.
