Swainsonine-induced vacuolar degeneration is regulated by mTOR-mediated autophagy in HT22 cells.

The indolizidine alkaloid, swainsonine (SW), is the main toxic component of locoweed, which can cause locoism in animals with characteristic neurological dysfunction. Pathological manifestations at cellular level include extensive vacuolar degeneration. Studies have shown that SW can induces autophagy, but the role and mechanism of autophagy in SW-induced vacuolar degeneration is unclear.

Highly-efficient visible-light-driven photocatalytic H evolution integrated with microplastic degradation over MXene/ZnCdS photocatalyst.

The development of highly-efficient photocatalyst for H production integrated with microplastic degradation is significant to meet the demand for clean energy and resolve "white pollution". Herein, a series of MXene/ZnCdS photocatalysts were successfully fabricated for H evolution integrated with degradation of polyethylene terephthalate (PET). The resultant photocatalysts exhibited excellent photocatalytic performance, and the best photocatalytic H evolution rate can reach 14.

Mechanism underlying treatment of ischemic stroke using acupuncture: transmission and regulation.

The inflammatory response after cerebral ischemia/reperfusion is an important cause of neurological damage and repair. After cerebral ischemia/reperfusion, microglia are activated, and a large number of circulating inflammatory cells infiltrate the affected area. This leads to the secretion of inflammatory mediators and an inflammatory cascade that eventually causes secondary brain damage, including neuron necrosis, blood-brain barrier destruction, cerebral edema, and an oxidative stress response.