Exploring the active ingredients and potential mechanisms of Pingchan granules in Parkinson's disease treatment through network pharmacology and transcriptomics.

Parkinson's disease (PD), the second most prevalent neurodegenerative disorder, poses significant challenges to single-target therapeutic strategies due to its complex etiology. This has driven interest in multi-target approaches, particularly those leveraging natural compounds. Pingchan granules (PCG), a traditional Chinese medicine composed of plant- and animal-derived compounds, have shown efficacy in alleviating PD symptoms.

Potent and broadly neutralizing antibodies against sarbecoviruses elicited by single ancestral SARS-CoV-2 infection.

The emergence of various SARS-CoV-2 variants presents challenges for antibody therapeutics, emphasizing the need for more potent and broadly neutralizing antibodies. Here, we employed an unbiased screening approach and successfully isolated two antibodies from individuals with only exposure to ancestral SARS-CoV-2. One of these antibodies, CYFN1006-1, exhibited robust cross-neutralization against a spectrum of SARS-CoV-2 variants, including the latest KP.

Numerical investigation on the penetration process of steel casings in riprap environment of estuarine mudflats.

The widespread distribution of riprap in estuarine mudflats has brought significant challenges to the penetration construction of steel casings. To reveal the effects of casing length, diameter and wall thickness on the stress and deformation, as well as the deformation characteristics and mechanical behaviors of the steel casing during the sinking process, the paper utilizes finite element method to construct a three-dimensional numerical model of the collision between steel casings and riprap in mudflat. The research results indicate that longer steel casing has better crushing effect on the riprap, smoother deflection curve of the casing body and smaller deformation at the casing end under the same casing diameter and wall thickness conditions.

Host FSTL1 defines the impact of stem cell therapy on liver fibrosis by potentiating the early recruitment of inflammatory macrophages.

Adult stem cell therapy holds great promise for treating decompensated liver cirrhosis on the basis of animal studies, despite uncertainty about its clinical therapeutic efficacy and unclear underlying mechanisms. Here, we investigated the role of follistatin-like 1 (FSTL1), a profibrotic and proinflammatory matricellular protein, in inflammation-related heterogeneity in stem cell therapy. Our results showed that a high level of circulating FSTL1 is significantly correlated with therapeutic response in patients with cirrhosis.

Oxytocin improves maternal licking behavior deficits in autism-associated Shank3 mutant dogs.

Impaired social interaction and repetitive behavior are key features observed in individuals with autism spectrum disorder (ASD). SHANK3 is a high-confidence ASD risk gene that encodes an abundant scaffolding protein in the postsynaptic density. In wild-type (WT) domestic dogs, maternal behaviors such as licking and nursing (largely milk feeding) of puppies are most commonly observed.

Equivalent-input-disturbance based rotating control of drill-string in compound directional drilling process subject to coal seam variation.

Coal seam variations in coal mine drilling can cause fluctuations in feed speed and rotational speed of the rotary head (ROR), reducing the performance of compound directional drilling control systems. This paper addresses these issues by considering the change in intrinsic specific energy caused by coal seam variations as a disturbance. An equivalent-input-disturbance (EID) based control system is designed to mitigate these effects.

[Preliminary study on the value of serum pepsinogen in differentiating autoimmune gastritis].

This study identifies independent predictive indicators to distinguish autoimmune gastritis from ()-induced atrophic gastritis and validates their diagnostic performance to compare laboratory indicators of autoimmune gastritis and -induced atrophic gastritis. A retrospective comparison of laboratory examination indicators was conducted for chronic atrophic gastritis patients with involvement of the gastric fundus and corpus, who were followed up at the Department of Gastroenterology, Xijing Hospital, from January 2014 to September 2024. Receiver operating characteristic (ROC) curves were utilized to determine the optimal cutoff points and corresponding diagnostic thresholds.

Cellulose-derived hydrogel with low vaporization enthalpy enables highly efficient solar steam generation.

Cellulose has drawn much attention in the field of interfacial solar steam generation (ISSG) due to its advantages of renewability, abundant availability, and hydrophilicity. However, the hydroxyl groups of cellulose form weak hydrogen bond interaction with water, resulting in high evaporation enthalpy and thereby low evaporation rate. Herein, carboxylic acid groups possess of strong interaction with water were introduced into cellulose hydrogel to fabricate efficient ISSG.

Synergistic catalytic degradation of benzene and toluene on spinel MMnO (MCo, Ni, Cu) catalysts.

Owing to the complexity of multicomponent gases, developing multifunctional catalysts for synergistic removal of benzene and toluene remains challenging. The spinel MMnO (MCo, Ni, or Cu) catalysts were successfully synthesized via the sol-gel method and tested for their catalytic performance for simultaneous degradation of benzene and toluene. The CuMnO sample exhibited the best catalytic performance, the conversion of benzene reached 100 % at 350 °C, and toluene conversion reached 100 % at 250 °C.

Developing an interpretable machine learning model for screening depression in older adults with functional disability.

This study utilized data from the 2020 wave of the China Health and Retirement Longitudinal Study database, selecting 4322 participants aged 60 and above as the study sample. Important predictors of depression in older adults with functional disabilities were identified using LASSO regression, univariate logistic regression, and multivariate logistic regression. Five different machine learning algorithms-Logistic Regression, Random Forest, Gradient Boosting, K-Nearest Neighbors, and Naive Bayes-were employed to construct risk prediction models for depression in older adults with functional disabilities.

A human-infecting H10N5 avian influenza virus: clinical features, virus reassortment, receptor-binding affinity, and possible transmission routes.

Background: In late 2023, the first human case caused by an H10N5 avian influenza virus (AIV) was diagnosed in China. H10Ny AIVs have been identified in various poultry and wild birds in Eurasia, the Americas, and Oceania.

Methods: We analyzed the clinical data of the H10N5 AIV-infected patient, isolated the virus, and evaluated the virus receptor-binding properties together with the H10N8 and H10N3 AIVs identified in humans and poultry.

MdNAC2 enhances K deficiency stress tolerance by maintaining K homeostasis in apple.

Potassium (K) is an essential nutrient for apple production, with its deficiency severely compromising yield and fruit quality. The development of K deficiency-resistant rootstocks represents an effective and promising approach to alleviating the adverse effects of K deficiency stress. However, the molecular mechanisms underlying apple resistance to K deficiency remain poorly understood.

Proteomic analysis reveals that Acalypha australis L. mitigates chronic colitis by modulating the FABP4/PPARγ/NF-κB signaling pathway.

Ethnopharmacological Relevance: Acalypha australis L. (AAL), a traditional medicinal herb from the Euphorbiaceae family, has been widely used in Chinese medicine for its heat-clearing, detoxifying, and diuretic properties, as well as for treating gastrointestinal disorders such as diarrhea and dysentery. Its reported anti-inflammatory and hemostatic effects are closely linked to inflammatory pathways.

Targeting the CXCR7 pathway with TC14012 to inhibit endothelial necroptosis and lung cancer metastasis.

Endothelial necroptosis plays a crucial role in regulating cancer metastasis. Our previous research demonstrated that TC14012, which is an agonist of CXCR7, exhibits protective effects against endothelial injury. This study was designed to elucidate the effects of TC14012 on endothelial necroptosis and cancer lung metastasis, along with deciphering the underlying molecular mechanisms.

Structural evaluation and formation regularities of garlic clove-like meat in prefabricated grass carp.

Moderately marinated fish meat forms a garlic clove-like structure after cooking. However, this structure's formation mechanism and influencing factors are unclear. Therefore, this study explored the changes in protein components and potential protein markers during the formation of garlic clove-like structure.

Multi-omics analysis revealed the effects of different astaxanthin sources on the antioxidant properties of Scylla paramamosain.

Astaxanthin, a carotenoid present in many organisms, has antioxidant, coloration, and anti-inflammatory benefits, making it a safe and effective feed additive. In this study, Scylla paramamosain fed diets with 100 mg/kg synthetic astaxanthin and 25 mg/kg Haematococcus pluvialis exhibited the best growth performance. Increased astaxanthin levels in the feed also resulted in red coloration of the carapace.

Toosendanin-induced liver damage through irreparable DNA damage and autophagy flow blockade.

Objective: The fruit of Melia toosendan Sieb. et Zucc. (MT) is known for its efficacy in relieving pain and treating roundworms.

Monocytes from patients with myelodysplastic syndrome inhibit natural killer cell-mediated antitumor function through the CD200/CD200R pathway.

Background: Reports on the expression of CD200 in monocytes are scarce, and the role of monocytes in patients with myelodysplastic syndrome (MDS) remains unclear. Additionally, monocytes have been implicated in suppressing NK cell function. Therefore, this study aimed to explore the possible mechanism by which monocytes regulate NK cell function through CD200 in patients with MDS.

Joint coil sensitivity and motion correction in parallel MRI with a self-calibrating score-based diffusion model.

Magnetic Resonance Imaging (MRI) stands as a powerful modality in clinical diagnosis. However, it faces challenges such as long acquisition time and vulnerability to motion-induced artifacts. While many existing motion correction algorithms have shown success, most fail to account for the impact of motion artifacts on coil sensitivity map (CSM) estimation during fast MRI reconstruction.

The combination of flaxseed lignans and PD-1/ PD-L1 inhibitor inhibits breast cancer growth via modulating gut microbiome and host immunity.

Background: Patients with breast cancer (BC) who benefit from the PD-1/PD-L1 inhibitor (PDi) is limited, necessitating novel strategies to improve immunotherapy efficacy of BC. Here we aimed to investigate the inhibitory effects of flaxseed lignans (FL) on the biological behaviors of BC and evaluate the roles of FL in enhancing the anticancer effects of PDi.

Methods: HPLC was used to detect the content of enterolactone (ENL), the bacterial transformation product of FL.

Healthy lifestyle habits, educational attainment, and the risk of 45 age-related health and mortality outcomes in the UK: A prospective cohort study.

Objectives: This study aimed to evaluate to what extent lifestyle habits, contribute to associations between EA and various conditions, and test the variability in risk reduction for specific health conditions linked to a healthy lifestyle across different EA levels.

Design, Setting, Participants, And Measurements: Data were analyzed from 341,632 UK Biobank participants without baseline cardiovascular disease or cancer (2006-2010). A healthy lifestyle score (0-5) was created by assigning one point for each of five habits: a healthy diet, sufficient physical activity, non-current smoking, moderate alcohol consumption, and low-risk sleep duration.

Synthesis, anti-allergic rhinitis evaluation and mechanism investigation of novel 1,2,4-triazole-enamides as CB1 R antagonist.

Allergic rhinitis (AR) is a non-infectious inflammatory disease and affects nearly half of the world's population currently, thus becoming a global health problem. In our study, a series of 1,2,4-triazole enamides were designed and used to evaluate the anti-inflammatory activity of AR. We found that compound 11g could significantly reduce the increased expression of interleukin-6 (IL-6), interleukin-1β (IL-1β) and tumor necrosis factor-α (TNF-α) in Raw264.