Many peptide hormones adopt long α-helical structures upon interacting with their cognate receptors but often exhibit flexible conformations when unbound. Strategies that can stabilize long α-helices without disrupting their binding to receptors are still lacking, which hinders progress in their biological applications and drug development. Here, we present an approach that combines rational design with library screening to create and identify a unique disulfide-directed multicyclic peptide (DDMP) scaffold, which could effectively stabilize N-terminally extendable α-helices while displaying exceptional efficiency in disulfide pairing and oxidative folding.
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March 2020
This work designed and synthesized the first organic fluorescent sensor for curcumin in aqueous media based on red-to-green fluorescence change of acylhydrazone-bridged bis-tetraphenylethylene (Bis-TPE). Bis-TPE was prepared by condensation of formyltetraphenylethylene with dihydrazide oxalate in 86% yield. It has the large conjugated electron effect with strong red AIE fluorescence in aqueous solution.
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