Pilot Study of Acute and Subchronic Oral Toxicological Biosafety Evaluation of Resorcinol-Formaldehyde Aerogel Nanomaterial in Kunming Mice.

Resorcinol-formaldehyde aerogel (RFa) is a unique nanomaterial composed of polymer nanoparticles with a three-dimensional network structure. Our previous studies have demonstrated its application in the separation and purification of alkaloids, and we are exploring its application potential as the drug delivery carrier. Therefore, it is necessary to comprehensively understand the in vivo toxicity profile of RFa and evaluate its oral biosafety.

The water extract of Amydrium sinense (Engl.) H. Li ameliorates Isoproterenol-induced cardiac hypertrophy through inhibiting the NF-κB signaling pathway.

Objective: Pathologic cardiac hypertrophy (PCH) is a precursor to heart failure. Amydrium sinense (Engl.) H.

Application of protein/polysaccharide aerogels in drug delivery system: A review.

Drug delivery systems have emerged as a prominent research focus in the field of drug development, offering enhanced stability and improved bioavailability. Among them, protein (silk, gelatin and whey) or polysaccharide (alginate, chitosan, cellulose, starch, pectin and carrageenan) aerogels derived from natural sources have gained increasing popularity due to their unique advantages, such as cost-effectiveness, flexible preparation, bioactivity, biocompatibility, and biodegradability. However, despite their growing significance, there remains a lack of comprehensive information and ongoing confusion regarding the application of protein/polysaccharide aerogels in drug delivery system.

Aqueous extract of alleviates hepatic fibrosis by suppressing hepatic stellate cell activation through inhibiting Stat3 signaling.

The present study aimed to investigate the protective effect of the water extract of (Engl.) H. Li (ASWE) against hepatic fibrosis (HF) and clarify the underlying mechanism.

Yao medicine suppresses hepatic fibrosis by repressing hepatic stellate cell activation STAT3 signaling.

Hepatic fibrosis (HF) occurs in response to chronic liver injury and may easily develop into irreversible liver cirrhosis or even liver cancer. water extract (AHWE) is a water-soluble component extracted from the Yao medicine (H.Li, Y.

Comparative Analysis of the Metabolites and Biological Activity of Cultivated and Wild .

In this paper, (Cooke) Ryvarden () cultivated in rice medium (LRR) and in sawdust medium (LRS) was harvested. Then, in terms of the LRR, LRS, and wild (LRW), the total flavonoid contents, total polyphenol contents, total polysaccharide contents, and metabolites were detected; antioxidants of their aqueous extracts and anti-inflammatory of their polysaccharides were performed. In addition, the possible mechanism of the polysaccharides of inhibiting lung damage was elucidated.

The Potential Antioxidant Activity and Characterization of Bioactive Compounds of .

() has anti-inflammatory, antinociceptive, and antipyretic activities; however, there are no literature reports on its antioxidant capacity. This study presents a comparative assessment of the polyphenols contents, flavonoids contents, and antioxidant activity of the aqueous and methanol extracts of (ASI and MSI). Moreover, the expression of oxidative stress-related genes in HO-induced H9c2 cells pretreated with the MSI was measured by RT-qPCR, and furthermore, MSI were characterized by UHPLC-Q-Orbitrap-MS/MS.