Modulating the Hydrogen Bond for a Stable Zinc Anode with a Wide Temperature Range via the Sucrose and Polyacrylamide Synergistic Effect.

Zinc-ion batteries become a major research focus in energy storage, valued for their low cost and high safety. However, their widespread application is hindered by poor zinc anode stability caused by dendrites, side reactions, and poor performance across a wide temperature range at a strong hydrogen bond network aqueous electrolyte. In this study, we propose a strategy for the synergistic combination of a polyacrylamide hydrogel with sucrose.

Public spheres or echo chambers? Nonprofit E-advocacy and civic engagement on harm reduction policy in the U.S.

This study examines how social media platforms shape drug policy advocacy by analyzing stakeholder engagement surrounding supervised consumption sites in New York City. While research has explored organizational use of social media for advocacy, less attention has focused on patterns of civic engagement and dialogue. Analyzing messages and comments from two opposing organizations-OnPoint NYC and Harlem East Block Association-over 24 months (2022-2023), we investigate whether social media-based drug policy advocacy creates public spheres for diverse dialogue or echo chambers of like-minded individuals.

Optimized microwave absorption and thermal properties for TiB@BN/PDMS composites via TiB@BN heterogeneous interface engineering.

The single electromagnetic (EM) wave loss mechanism leads to suboptimal microwave absorption in dielectric materials, whereas, introducing different materials and constructing distinctive microstructures can significantly improve microwave absorption. In this study, TiB and TiB@BN powders were synthesized using boron thermal reduction and chemical solution methods. Their microwave absorption and thermal properties were systematically analyzed.

Estimation of optimal culture conditions for Gedaniella panicellus GPYS21 (Fragilariaceae) as a high-yield bioresource for palmitoleic acid and fucoxanthin production.

Gedaniella panicellus, a marine diatom belonging to the family Fragilariaceae, has not yet been explored for its biotechnological potential. This study aimed to optimize the growth of G. panicellus using response surface methodology and assess its cellular biochemical composition to verify the production of value-added compounds.

Indoloquinoline alkaloid neocryptolepine derivative inhibits by targeting thiamine thiazole synthase.

The emergence and rapid spread of multidrug-resistant strains pose a great challenge to the quality and safety of agricultural products and the efficient use of pesticides. Previously unidentified fungicides and targets are urgently needed to combat -associated infections as alternative therapeutic options. In this study, the promising compound Z24 demonstrated efficacy against all tested plant pathogenic fungi.

Splenic red pulp macrophages eliminate the liver-resistant from the blood circulation of mice.

Invasive infections by encapsulated bacteria are the major cause of human morbidity and mortality. The liver resident macrophages, Kupffer cells, form the hepatic firewall to clear many encapsulated bacteria in the blood circulation but fail to control certain high-virulence capsule types. Here we report that the spleen is the backup immune organ to clear the liver-resistant serotypes of (pneumococcus), a leading human pathogen.

Biodetoxification of both AFB1 and ZEN by Bacillus subtilis ZJ-2019-1 in gastrointestinal environment and in mice.

Aflatoxin B1 (AFB1) and zearalenone (ZEN) are the most prevalent mycotoxins in production, posing a serious threat to human and animal health. Therefore, it is very urgent to find a safe and efficient method for the biodegradation of these mycotoxins. Our previous study demonstrated that Bacillus subtilis ZJ-2019-1 moderately degrades both mycotoxins in vitro and ZEN in female gilts.

Tangeretin regulates oxidative stress in cutaneous melanoma cells via the Nrf2 signaling pathway.

Oxidative stress is a key factor in melanoma progression, making it an important therapeutic target. This study explored the effects of tangeretin, a citrus-derived flavonoid, on human melanoma A375 cells and its underlying mechanisms. A375 cells were treated with tangeretin at various concentrations.

MoSe/BiSe Heterostructure Immobilized in N-Doped Carbon Nanosheets Assembled Flower-Like Microspheres for High-Rate Sodium Storage.

A key challenge for sodium-ion batteries (SIBs) lies in identifying suitable host materials capable of accommodating large Na ions while addressing sluggish chemical kinetics. The unique interfacial effects of heterogeneous structures have emerged as a critical factor in accelerating charge transfer and enhancing reaction kinetics. Herein, MoSe/BiSe composites integrated with N-doped carbon nanosheets are synthesized, which spontaneously self-assemble into flower-like microspheres (MoSe/BiSe@N-C).

Negative Enthalpy Doping Stabilizes P2-Type Oxides Cathode for High-Performance Sodium-Ion Batteries.

P2-type NaNiMnO (NNMO) as cathode material for sodium-ion batteries (SIBs) largely suffers from continuous accumulation of local stress caused by destructive structural evolution and irreversible oxygen loss upon cycling, leading to rapid capacity degradation. Herein, a strategy of negative enthalpy doping (NED), wherein transition metal (TM) sites are substituted with 0.01 mol each Sn, Sb, Cu, Ti, Mg, and Zn to increase the stability of the TM layers, is proposed.

Establishment and Its Utility of a Patient-Derived Cell Xenografts (PDCX) Model with Cryopreserved Cancer Cells from Human Tumor.

Patient-derived xenograft (PDX) models are powerful tools in cancer research, offering an accurate platform for evaluating cancer treatment efficacy and predicting responsiveness. However, these models necessitate surgical techniques for tumor tissue transplantation and face challenges with non-uniform tumor growth among animals. To address these issues, we attempted to develop a new PDX modeling method using high-grade serous ovarian cancer (HGSC), a fatal disease with a 5-year survival rate of 29%, which requires personalized research due to its morphological, genetic, and molecular heterogeneities.

Continuous R-DA-EDOCH alternated with high-dose Ara-C induces deep remission and overcomes high-risk factors in young patients with newly diagnosed mantle cell lymphoma.

Objective: Our previous studies have indicated potentially higher proliferative activity of tumor cells in Chinese patients with mantle-cell lymphoma (MCL) than those in Western. Given the success and tolerability of R-DA-EDOCH immunochemotherapy in treating aggressive B-cell lymphomas, we designed a prospective, phase 3 trial to explore the efficacy and safety of alternating R-DA-EDOCH/R-DHAP induction therapy for young patients with newly diagnosed MCL. The primary endpoint was the complete remission rate (CRR) at the end of induction (EOI).

A Program for Reinforcing Lifestyle Change Motivation and Lifestyle Behavior to Prevent Dementia in Community-Dwelling Middle-Aged and Older Adults: Applying the Health Belief Model.

This study aimed to explore the applicability of a dementia prevention lifestyle change program based on the Health Belief Model in the community. A total of 9 participants were included in this study. The participants completed a 10-session program using the KEEP strategy.

Isolation and evaluation of growth-promoting endophytic bacteria from Hemsl.

The slow growth rate of Hemsl. (Zanthoxylum) is the important factor causing the scarcity of its available wild resource. It has been reported that the plant endophytes can promote the plant growth and the synthesis of secondary metabolitesby by enhancing the efficiency of nutrient absorption by plants and regulating plant hormones.

A Prospective Observational Study to Evaluate the Actual Use of 1% Pimecrolimus in Chinese Patients with Mild-to-Moderate Atopic Dermatitis Affecting Sensitive Skin Areas.

Introduction: Atopic dermatitis (AD) is a common inflammatory skin disorder that affects both children and adults, characterized by pruritus and scaly, dry eczematous lesions. This study aimed to gather knowledge on the actual use and effectiveness of Pimecrolimus (PIM) in Chinese patients with mild-to-moderate AD affecting sensitive skin areas in routine clinical practice.

Methods: This multicentre and non-interventional study included 130 subjects from China, divided into two age groups (2-12 years and ≥12 years).

Integrated spatial multi-omics profiling of Fusobacterium nucleatum in breast cancer unveils its role in tumour microenvironment modulation and cancer progression.

Tumour-associated microbiota are integral components of the tumour microenvironment (TME). However, previous studies on intratumoral microbiota primarily rely on bulk tissue analysis, which may obscure their spatial distribution and localized effects. In this study, we applied in situ spatial-profiling technology to investigate the spatial distribution of intratumoral microbiota in breast cancer and their interactions with the local TME.

Regulation of immune microenvironments by polyetheretherketone surface topography for improving osseointegration.

Optimizing the immune microenvironment is essential for successful implant osseointegration. In this study, four different nano/microstructures were fabricated on polyetheretherketone (PEEK) substrates by varying the agitation speed during sulfonation to influence osteoimmunomodulation and implant integration. The results indicate that nano/microstructures with minimal dimensions (SP450) inhibit actin polymerization by reducing calcium influx through PIEZO1, activating the anti-inflammatory M2 macrophage phenotype.

RBM10 deficiency promotes brain metastasis by modulating sphingolipid metabolism in a BBB model of EGFR mutant lung adenocarcinoma.

Background: Brain metastasis significantly contributes to the failure of targeted therapy in patients with epidermal growth factor receptor (EGFR)-mutated lung adenocarcinoma (LUAD). Reduced expression of RNA-binding motif protein 10 (RBM10) is associated with brain metastasis in these patients. However, the mechanism by which RBM10 affects brain metastasis in EGFR-mutated LUAD remains unclear.

USP10/XAB2/ANXA2 axis promotes DNA damage repair to enhance chemoresistance to oxaliplatin in colorectal cancer.

Background: Oxaliplatin-based chemotherapy is the first-line treatment for colorectal cancer (CRC). However, oxaliplatin resistance remains a major challenge contributing to treatment failure and poor prognosis. An increased capacity for DNA damage repair is a key mechanism underlying oxaliplatin resistance.

Potential biomarkers develop for predicting the prognosis of patients with esophageal squamous cell carcinoma after optimized chemoradiotherapy using serum metabolomics.

Background: Esophageal squamous cell carcinoma (ESCC), the most common type of esophageal cancer, characterized by low five-year survival rate, and concurrent chemoradiotherapy (CCRT) has been proposed to treat ESCC, while potential biomarkers for prognostic monitoring after optimized CCRT remains unknown.

Methods: Serum samples from 45 patients with ESCC were collected and categorized into three groups: Control (pre-CCRT), CCRT (during CCRT), and CCRT-1 M (one-month post-CCRT). The therapeutic effect was evaluated using CT imaging and established evaluation criteria.

PTN activity in quiescent neural stem cells mediates Shank3 overexpression-induced manic behavior.

Mania is a complex psychiatric disease characterized by hyperactivity, elevated mood and reduced anxiety. Despite extensive studies on the mechanism of the manic episodes, the molecular targets that control manic pathogenesis remain largely unclear. Here, through single-cell RNA sequencing (scRNA-seq) analysis, we show aberrant adult neurogenesis due to increased numbers of quiescent neural stem cells (qNSC) in a manic mouse model with Shank3 overexpression.

Thalidomide-based regimen shows promising efficacy in large granular lymphocytic leukemia: a multicenter phase II study.

Large granular lymphocytic leukemia (LGLL) is characterized by the clonal proliferation of cytotoxic T lymphocytes or NK cells. Standard first-line immunosuppressive treatments have limitations, achieving complete remission (CR) rates of up to 50%. Immune system dysregulation is implicated in LGLL.

Safety and efficacy of provocative angiography for localization and treatment of gastrointestinal hemorrhage.

Purpose: Mesenteric angiography and embolization is an effective treatment of gastrointestinal bleeding. In the setting of occult bleeding, provocative maneuvers with intra-arterial vasodilators and thrombolytics can increase the diagnostic yield of angiography. This study aimed to assess the clinical outcomes of provocative angiography and factors that increase the positivity rate for active bleeding at the time of provocation.

Brazilin reduces methicillin-resistant Staphylococcus aureus virulence and pathogenicity by decreasing the secretion of the α-hemolysin.

Background: Methicillin-resistant Staphylococcus aureus (MRSA) is a super-resistant bacterium with strong pathogenicity, causing broad range of infections in various tissues. α-Hemolysin (Hla) is the main virulence factor of S. aureus.