Inhibitory Effect of Imperatorin on the Pharmacokinetics of Diazepam In Vitro and In Vivo.

Background: Diazepam is a benzodiazepine drug used to treat anxiety, insomnia, and muscle spasms. Imperatorin is a phytochemical isolated from medicinal plants and is widely used in herbal medicine. The aim of this study was to investigate the interactions between imperatorin and diazepam and and to provide evidence-based guidance for the safe clinical use of the drug.

[Studies on optimal extraction conditions of flavonoid from the flowers of Edgeworthia chrysantha].

Objective: To study the optimum extraction process of the total flavonoids from the flowers of Edgeworthia chrysantha Lindl.

Methods: The effect of the concentration of ethanol, extraction time and ratio of material to liquid on the total flavonoid contents were investigated by the orthonogal test with the content of tiliroside as the chemical reference.

Results: The optimum extraction condition was established as follows: the concentration of ethanol 75%, extraction time 1.