Publications by authors named "Bingjun Lei"
Article Synopsis
- Excess activation of inflammatory microglia worsens spinal cord injury (SCI), and inhibiting the protein Arhgef3 can reduce this inflammation.
- In laboratory tests and animal models, increased Arhgef3 levels were linked to heightened microglial activity and inflammatory responses.
- Reducing Arhgef3 not only lowered inflammation and reactive oxygen species production after injury but also led to improved recovery and reduced secondary damage in mice, suggesting it may be a potential target for treating SCI.
Article Synopsis
- NPC degeneration is a key factor in intervertebral disc diseases, and this study explores using autologous chondrocytes (CHs) that overexpress the sirt1 gene to improve NPC health.
- The research shows that co-culturing NPCs with sirt1-overexpressed CHs leads to increased cell viability and reduced signs of degeneration, indicating that these CHs promote better NPC condition.
- This approach could offer a novel treatment strategy for intervertebral disc degeneration by mitigating oxidative stress and inflammation in NPCs.
[Calcaneal plate bridge reconstruction plate for acetabular fracture involving quadrilateral surface via modified Stoppa approach].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
October 2020
Article Synopsis
- The study aimed to assess the effectiveness of the calcaneal plate bridge reconstruction for treating acetabular fractures using the modified Stoppa approach, analyzing data from 18 patients over a few years.
- The patient demographics included 12 males and 6 females aged between 28 to 63, with most injuries caused by traffic accidents, and various types of fractures classified by the Letournel-Judet system.
- Post-operative results showed a high satisfaction rate of 94.4% in reduction quality, with all fractures healing within an average of 3.4 months and no complications like internal fixator failure detected by the last follow-up.
[Application of improved injecting tube in percutaneous kyphoplasty through unipedicular puncturing].
Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi
February 2017
Article Synopsis
- The study aimed to evaluate the effectiveness of percutaneous kyphoplasty (PKP) using an improved injecting tube through a single puncture site for treating osteoporotic vertebral compression fractures.
- During the research period, 60 cases were analyzed, with one group using a routine injecting tube and the other using an improved version, showing no significant differences in key preoperative metrics or complication rates.
- Results indicated that while both methods improved postoperative outcomes like pain and vertebral height, the improved injecting tube offered better bone cement distribution, suggesting it could be a more effective option without increasing operation time or complication risks.
[Association of interleukin 28B polymorphisms with response to pegylatedinterferon plus ribavirin therapy for chronic hepatitis C].
Sichuan Da Xue Xue Bao Yi Xue Ban
November 2012
Article Synopsis
- The study explored the link between the IL28B rs12979860 gene polymorphism and the effectiveness of antiviral therapy in chronic hepatitis C patients in Sichuan, China, finding a significant association between the IL28B CC genotype and higher treatment success rates.
- Among 56 patients, the majority had the CC genotype (76.8%), with a high sustained virological response (SVR) rate of 82.1%, notably higher in those with the CC genotype compared to the CT genotype (90.7% vs. 53.8%).
- The research indicated that the therapeutic efficacy of PEG-IFN alpha-2a plus RBV was enhanced in patients with the CC genotype, especially those with higher baseline
[Lamivudine-resistant analysis and management for chronic hepatitis B patients with initial lamivudine therapy].
Zhonghua Gan Zang Bing Za Zhi
June 2011
Article Synopsis
- The study examined long-term lamivudine use in chronic hepatitis B patients, focusing on factors influencing its effectiveness and resistance management.
- A total of 383 patients were treated and tracked over 10 years, with 129 developing lamivudine resistance, divided into two treatment groups for further analysis.
- Key findings revealed that a significant proportion achieved HBV DNA negativity and seroconversion after treatment, but high initial viral loads and low ALT levels were linked to higher rates of viral rebound, highlighting the different effectiveness of alternative therapies post-resistance.
Article Synopsis
- The study investigates the relationship between treatment duration and cumulative doses of pegylated interferon alpha-2a (PegIFN alpha-2a) plus ribavirin (RBV) on antiviral therapy effectiveness in 117 patients with hepatitis C.
- Patients were grouped by age, weight, and other factors, with significant findings indicating younger patients and those with shorter infections had higher sustained virological response (SVR) rates.
- Results showed that both treatment length and total cumulative doses of PegIFN and RBV positively correlated with improved SVR rates, with longer treatment periods and higher doses leading to better outcomes.
[Progress of researches on liver-specific transcriptional regulatory sequence].
Sheng Wu Yi Xue Gong Cheng Xue Za Zhi
April 2009
Article Synopsis
- Gene therapy has rapidly advanced, but concerns remain about the safety and effectiveness of gene expression in specific times and locations.
- Using tissue or cell-specific transcriptional regulatory elements can enhance the precision of gene expression, particularly in targeting hepatic tissue for liver-related conditions.
- Recent research highlights advancements in liver-specific transcriptional regulatory sequences, which are valuable for understanding disease mechanisms and improving gene therapy outcomes for liver diseases.
Article Synopsis
- The study assessed the effectiveness and safety of adefovir dipivoxil (ADV) for treating Chinese patients with chronic hepatitis B who are resistant to lamivudine (LAM).
- After 24 and 48 weeks, patients on ADV showed significantly greater reductions in HBV DNA levels compared to those on LAM, alongside better virological responses and liver function normalization.
- The treatment was found to be effective and safe, with no severe adverse events reported related to ADV.
[Problems and strategies in the application of artificial livers].
Zhonghua Gan Zang Bing Za Zhi
September 2006
[A study of the dosage and efficacy of entecavir for treating hepatitis B virus].
Zhonghua Gan Zang Bing Za Zhi
July 2005
Article Synopsis
- The study aimed to assess the antiviral effectiveness and safety of two different doses of entecavir in patients with chronic HBV before moving to larger trials.
- In a randomized trial with 212 participants, both 0.1 mg and 0.5 mg doses of entecavir significantly reduced HBV DNA levels compared to a placebo after 28 days.
- The 0.5 mg dose showed better and longer-lasting viral suppression than the 0.1 mg dose, with no major safety concerns, suggesting it is the preferred choice for future studies.
[Influence of wen-yang herbs on hemodynamics in liver fibrotic rats].
Zhonghua Gan Zang Bing Za Zhi
June 2005
Article Synopsis
- The study aimed to investigate the effects of wen-yang herbs on blood flow and liver function in rats with induced liver fibrosis.
- Rats were divided into a treatment group receiving wen-yang herbs and a control group given saline, with comparisons made on various hemodynamic and liver function parameters.
- Results showed significant improvements in blood volume, blood flow velocity, and liver function in the treatment group, indicating that wen-yang herbs may enhance liver microcirculation and reduce collagen deposits.
Article Synopsis
- The study aimed to analyze the expression levels of HBsAg, HBcAg, p21, and Rb proteins in hepatocellular carcinoma (HCC) and their potential roles in cancer development.
- It involved using a tissue microarray of 40 HCC cases and comparing the expression rates of these proteins in cancerous, para-cancerous, and normal liver tissues.
- Results showed significantly lower expression rates of HBsAg and HBcAg in cancerous tissues compared to normal tissues, while higher deletion rates of p21 and Rb proteins were observed in tumors, indicating their potential involvement in HCC carcinogenesis.
[Pathological study of the therapeutic effect of wen-yang herbs on experimental liver cirrhosis].
Sichuan Da Xue Xue Bao Yi Xue Ban
July 2004
Article Synopsis
- The study aimed to assess the effects of wen-yang herbs on liver fibrosis in male Wistar rats, which were induced with the condition using CCl4 and alcohol.
- The rats were divided into four groups, with one group receiving herbal treatment and the others serving as controls, to evaluate changes in liver tissue through Hydroxyproline content and a scoring system.
- Results showed that the group treated with wen-yang herbs experienced significant reductions in liver fibrosis markers compared to the control group, indicating potential therapeutic benefits of these herbs.
Article Synopsis
- The study aimed to identify specific genes related to ESBLs (extended-spectrum beta-lactamases) in Klebsiella pneumoniae and Escherichia coli from clinical samples in West China Hospital.
- The researchers used PCR and bioinformatics to analyze gene sequences and discovered specific subtypes, namely SHV-2 and TEM-19, along with unique mutation patterns.
- The findings suggest SHV-2 is the predominant ESBL in the region, with evidence of evolutionary connections between SHV-2 and TEM-19 genes across different locations.
[Effects of Radix Salviae Miltiorrhizae on the PMN-EC adhesion in vitro at the early stage of endotoxemia].
Sichuan Da Xue Xue Bao Yi Xue Ban
May 2004
Article Synopsis
- The study investigates how Radix Salviae Miltiorrhizae (RSM) affects the adhesion of white blood cells to endothelial cells in a rabbit model of endotoxemia.
- RSM treatment results in significantly lower levels of adhesion molecules and TNF-alpha compared to the endotoxemia group, indicating that RSM can mitigate inflammatory responses.
- The findings suggest that RSM may improve microcirculation during endotoxemia by reducing adhesion rates and inflammatory markers.
Pathomorphological study on location and distribution of Kupffer cells in hepatocellular carcinoma.
World J Gastroenterol
September 2003
Article Synopsis
- The study aims to identify the location and distribution of Kupffer cells in hepatocellular carcinoma (HCC) and assess their role in cancer development.
- Using immunohistochemical techniques, researchers compared the number of Kupffer cells in cancerous, para-cancerous, and normal liver tissues from 48 patients with HCC.
- Results showed significantly fewer Kupffer cells in cancerous tissues compared to para-cancerous and normal tissues, indicating that lower Kupffer cell counts may be linked to tumor size and differentiation, suggesting they play a crucial role in HCC development.
Article Synopsis
- The study aimed to set up a reliable culture system for mouse embryonic fibroblasts (MEF).
- MEF were isolated from BALB/c mouse embryos, with optimal isolation occurring at 13.5 days of gestation, and found to have good growth properties by passage 3.
- Results indicate that MEFs (passage 3) are ideal for use as a feeder layer for embryonic stem cell cultures.
[Study on the activities of fluoroquinolones against Staphylococcus aureus and the effect of reserpine on these activities].
Hua Xi Yi Ke Da Xue Xue Bao
January 2002
Article Synopsis
- The study aimed to explore how fluoroquinolones interact with S. aureus and whether reserpine affects their efficacy.
- The methodology involved determining the minimal inhibitory concentrations (MICs) of fluoroquinolones and assessing reserpine's impact on these MICs using a standardized agar dilution technique.
- Findings indicate that while S. aureus shows cross resistance to fluoroquinolones, it does not exhibit significant multidrug resistance; reserpine can lower the MICs of these antibiotics, particularly for hydrophilic variants.
Article Synopsis
- The study investigates how the deficiency of outer membrane protein (Omp) F and the active drug efflux system affect the accumulation of hydrophilic fluoroquinolones in resistant E. coli strains.
- In experiments, different E. coli strains, including control and resistant ones, showed varying levels of drug accumulation, with OmpF-deficient strains accumulating significantly less ciprofloxacin and lomefloxacin compared to the control strains.
- The results indicate that active efflux systems play a critical role in reducing drug accumulation in resistant strains, suggesting that both OmpF deficiency and active efflux contribute to fluoroquinolone resistance in E. coli.
Article Synopsis
- Aim of the study was to create a safe and effective DNA vaccine to trigger immune responses against the hepatitis B virus surface antigen (HBsAg).
- BALB/c mice were vaccinated with a recombinant plasmid NV-HB/s, leading to detectable anti-HBs levels and strong cytotoxic T lymphocyte (CTL) activity, far superior to traditional plasma-derived vaccines.
- The study concluded that NV-HB/s successfully elicited both humoral and cellular immune responses against HBsAg, proving to be a safe vaccine option with sustained DNA presence in muscle tissues over time.