Publications by authors named "Bingjie Pan"
Article Synopsis
- Pulmonary hypertension (PH) is a severe disease linked to damage in blood vessels of the lungs and involves the degradation of important proteins, such as BMPR2, by the enzyme cathepsin L, leading to cell death through a process called pyroptosis.
- Research showed that cathepsin L levels are significantly higher in patients with pulmonary arterial hypertension, and its inhibition in animal models of PH improved conditions related to the disease, including reduced pressure in the heart and enhanced blood vessel health.
- The study concludes that cathepsin L contributes to the progression of PH by degrading BMPR2, which triggers a cascade leading to programmed cell death in endothelial cells, highlighting a potential therapeutic target for treating PH.
Herein, we developed a technique for loading nanopesticides onto Metal-Organic Frameworks (MOFs) to control Spodoptera litura. The average short-axis length of the synthesized carrier emamectin benzoate@PCN-222 @hyaluronic acid (EB@PCN-222 @HA) was ∼40 nm, with an average long-axis length of ∼80 nm. This enabled the manipulation of its size, contact angle, and surface tension on the surface of leaves.
View Article and Find Full Text PDFBackground: Endothelial dysfunction enhances vascular inflammation, which initiates pulmonary arterial hypertension (PAH) pathogenesis, further induces vascular remodeling and right ventricular failure. Activation of inflammatory caspases is an important initial event at the onset of pyroptosis. Studies have shown that caspase-1-mediated pyroptosis has played a crucial role in the pathogenesis of PAH.
View Article and Find Full Text PDFDecreased expression of prohibitin 1 mediates highmobility group protein 1induced pulmonary artery endothelial cell injury.
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2020
Objectives: There is a significant increase of high-mobility group protein B1 (HMGB1) in plasma levels of patients with pulmonary hypertension, but the biological significance is still unclear. Anti-proliferative protein 1 (prohibitin 1, PHB1) is an important protein that maintains the homeostasis of vascular cells. This study aimed to investigate the effect of HMGB1 on pulmonary artery endothelial cells and the role of PHB1.
View Article and Find Full Text PDFWhether the baseline circulating proprotein convertase subtilisin/Kexin type 9 (PCSK9) concentration associates with cardiovascular risk remains uncertain. This study aimed to investigate the predictive value of circulating PCSK9 in cardiovascular risk prediction.Relevant studies were searched through the MEDLINE, EMBASE, and Cochrane Library databases.
View Article and Find Full Text PDFBackground: PCSK9 rs505151 and rs11591147 polymorphisms are identified as gain- and loss-of-function mutations, respectively. The effects of these polymorphisms on serum lipid levels and cardiovascular risk remain to be elucidated.
Methods: In this meta-analysis, we explored the association of PCSK9 rs505151 and rs11591147 polymorphisms with serum lipid levels and cardiovascular risk by calculating the standardized mean difference (SMD) and odds ratios (OR) with 95% confidence intervals (CI).