Mechanisms and salvage treatments in patients with multiple myeloma relapsed post-BCMA CAR-T cell therapy.

Chimeric antigen receptor T-cell (CAR-T) therapy has ushered in a new era for the treatment of multiple myeloma (MM). Numerous clinical studies, especially those involving B-cell maturation antigen (BCMA)-directed CAR-T, have shown remarkable efficacy in patients with relapsed or refractory multiple myeloma (R/R MM). However, a considerable number of patients still experience disease recurrence or progression after BCMA CAR-T treatment, which is attributed to various factors, including antigen escape, CAR-T manufacturing factors, T cell exhaustion, inhibitory effects of tumor microenvironment and impact of prior treatments.

Antiaromatic Metallacyclopentatriene Complexes.

There is no report on the (anti)aromaticity of metallacyclopentatrienes, one kind of common and important five-membered metallacycles. This work presents the novel synthesis of osmium -biscarbene complexes and their oxidation to osmacyclopentatrienes. The osmacyclopentatriene unit is antiaromatic, as revealed by experimental and theoretical studies.

Synthesis and aromaticity of metallacyclopropene complexes.

Metallacycloprop-1-ene and metallacycloprop-2-ene complexes are the smallest unsaturated metallacycles, and have attracted continuing attention for their importance in organometallic synthesis and catalysis. This feature article summarizes the syntheses of monocyclic and fused metallacycloprop-2-enes, and monocyclic, spiro, and fused metallacycloprop-1-enes, all with crystallographically characterized structures. The aromatic properties of mononuclear metallacyclopropene complexes are also described.

Risk score constructed with neutrophil extracellular traps-related genes predicts prognosis and immune microenvironment in multiple myeloma.

Background: Multiple myeloma (MM) exhibits considerable heterogeneity in treatment responses and survival rates, even when standardized care is administered. Ongoing efforts are focused on developing prognostic models to predict these outcomes more accurately. Recently, neutrophil extracellular traps (NETs) have emerged as a potential factor in MM progression, sparking investigation into their role in prognostication.

Fused metallacyclopropenes from alkynylphenols.

Metallacycloprop-1-enes can be constructed from coordinated alkynes. In this work, we report a convenient synthesis of fused osmacyclopropene complexes 1 and 3 from OsCl(PPh) and alkynylphenols. Paramagnetic alkyne-coordinated phenolate complexes 2 were obtained as the key intermediates for the formation of osmacyclopropenes, demonstrating selective CC activation under different conditions.

Correction: A molecularly imprinted antibiotic receptor on magnetic nanotubes for the detection and removal of environmental oxytetracycline.

Correction for 'A molecularly imprinted antibiotic receptor on magnetic nanotubes for the detection and removal of environmental oxytetracycline' by Jixiang Wang , , 2022, , 6777-6783, https://doi.org/10.1039/D2TB00497F.

Anticancer Effects of Amlodipine Alone or in Combination With Gefitinib in Non-Small Cell Lung Cancer.

Amlodipine is a Ca channel blocker commonly used to cardiovascular diseases such as hypertension and angina; however, its anticancer effects in lung cancer A549 cells remain unknown. In the present study, we explored the antitumor effects and molecular mechanisms underlying the action of amlodipine in non-small cell lung cancer (NSCLC) A549 cells and . We observed that amlodipine suppressed the proliferation of A549 lung cancer cells by arresting the tumor cell cycle.

A molecularly imprinted antibiotic receptor on magnetic nanotubes for the detection and removal of environmental oxytetracycline.

The detection and elimination of antibiotic contaminants, such as oxytetracycline (OTC), a broad-spectrum tetracycline antibiotic, would be of help in efficient environmental monitoring, agriculture and food safety tests. Nevertheless, currently available methodologies, which mostly rely on the chromatographic separation of OTC, suffer from low sensitivity and complicated processes. Thus, we report here on the design and synthesis of a fluorescent sensor based on molecularly imprinted magnetic halloysite nanotubes (referred to as MHNTs@FMIPs) for the effective detection and purification of OTC in actual environmental samples.

Targeting c-Jun in A549 Cancer Cells Exhibits Antiangiogenic Activity and Through Exosome/miRNA-494-3p/PTEN Signal Pathway.

The oncogene c-Jun is activated by Jun N-terminal kinase (JNK). Exosomes are nanometer-sized membrane vesicles released from a variety of cell types, and are essential for cell-to-cell communication. By using specific JNK inhibitor SP600125 or CRISPR/Cas9 to delete c-Jun, we found that exosomes from SP600125-treated A549 cancer cells (Exo-SP) or from c-Jun-KO-A549 cells (Exo-c-Jun-KO) dramatically inhibited tube formation of HUVECs.

STIM1 promotes angiogenesis by reducing exosomal miR-145 in breast cancer MDA-MB-231 cells.

Cancer cells secrete abundant exosomes, and the secretion can be promoted by an increase of intracellular Ca. Stromal interaction molecule 1 (STIM1) plays a key role in shaping Ca signals. MicroRNAs (miRNAs) have been reported to be potential therapeutic targets for many diseases, including breast cancer.

Inhibitory effect of taxifolin on mast cell activation and mast cell-mediated allergic inflammatory response.

The aim of the present study is to investigate the anti-inflammatory and anti-allergic effects of taxifolin on mast cells and mast cell-mediated allergic reaction. We assessed the effect of taxifolin on the activation of bone marrow-derived mast cells (BMMCs) and rat basophilic leukemia (RBL)-2H3 cells induced by immunoglobulin E (IgE)/antigen (Ag), and the activation of human mast cell line (HMC-1) induced by PMA plus A23187. Taxifolin inhibited degranulation, generation of leukotriene C (LTC), production of interlukin-6 (IL-6), and expression of cyclooxygenase-2 (COX-2) through blocking intracellular Ca mobilization, phosphorylation of phospholipase Cγ (PLCγ) and mitogen-activated protein kinases (MAPKs), translocation of cytosolic phospholipase A (cPLA) and 5-lipoxygenase (5-LO), and Akt/IKK/NF-κB pathway, in BMMC cells.

Alisol B 23-Acetate Inhibits IgE/Ag-Mediated Mast Cell Activation and Allergic Reaction.

Alisol B 23-acetate (AB23A), a natural triterpenoid, has been reported to exert hepatoprotective and antitumor activities. Aiming to investigate the anti-inflammatory activity, this study examined the effect of AB23A on mast cells and allergic reaction. AB23A inhibited the degranulation of mast cells stimulated by immunoglobulin E/antigen (IgE/Ag), and also decreased the synthesis of leukotriene C₄ (LTC₄), production of interlukin-6 (IL-6), and expression of cyclooxygenase-2 (COX-2) in a concentration-dependent manner with no significant cytotoxicity in bone marrow-derived mast cells (BMMCs).

[Methylation status of JunB and CDH13 gene promoter in CD34(+)CD38(-) chronic myelogenous leukemia cells].

Chronic myelogenous leukemia (CML) is a clonal myeloproliferative disease of transformed hematopoietic progenitor cells. The expressions of JunB and CDH13 (cadherin-13) gene as tumor suppressor gene were inactivated by promoter methylation in CML patients. This study was purposed to investigate the methylation difference of JunB and CDH13 gene promoter and the expression levels of JunB and CDH13 gene in CD34(+)CD38(-) cells in CML patients vs normal individuals.

Berberine inhibits SDF-1-induced AML cells and leukemic stem cells migration via regulation of SDF-1 level in bone marrow stromal cells.

Berberine plays a prominent role on the control of tumor cell invasion and migration. SDF-1 is a homeostatic chemokine that signals through CXCR4 which is expressed by hematopoietic tumor cells. The SDF-1/CXCR4 axis is involved in the migration process of leukemic cells.