Publications by authors named "Bingjia Yu"
Article Synopsis
- * This study analyzed tissue samples to identify gene modules associated with the progression from normal cervix to cervical intraepithelial neoplasia and ultimately CC, using advanced techniques like transcriptome sequencing and machine learning models.
- * Findings revealed CARMN as a significant gene in CC, showing that reduced CARMN expression affects key cellular pathways, leading to an increased risk of CC, with specific genetic variants also linked to this risk.
4-NP (4-nonylphenol), a prevalent environmental endocrine disruptor with estrogenic properties, is commonly detected in drinking water and food sources. It poses a significant risk of endocrine disruption, thereby influencing the onset and progression of diverse diseases, including tumorigenesis. However, its specific impact on cervical cancer remains to be fully elucidated.
View Article and Find Full Text PDFPurpose: To explore the function and molecular mechanism of LINC00426 in Cervical Cancer (CC), and to explore the clinical treatment strategy of LINC00426 for CC.
Methods: Bioinformatics analysis was used to explore the expression of LINC00426 and patient prognosis of CC. Cell function experiments were conducted to explore the potential effect of LINC00426 on CC malignant phenotypes.
Object detection in drone-captured scenarios is a recent popular task. Due to the high flight altitude of unmanned aerial vehicle (UAV), the large variation of target scales, and the existence of dense occlusion of targets, in addition to the high requirements for real-time detection. To solve the above problems, we propose a real-time UAV small target detection algorithm based on improved ASFF-YOLOv5s.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates the role of lncRNA CARMN as a tumor suppressor in cervical cancer (CC) and explores how mA modification and miRNAs, specifically miR-21-5p, affect its expression.
- Using methods like MeRIP-seq and RT-qPCR, researchers found that CARMN has higher mA modification in tumor tissues, and that the mA reader YTHDF2 facilitates its degradation in CC cells.
- Additionally, miR-21-5p was identified as a direct regulator of CARMN, negatively impacting its levels, which suggests that both mA modification and miR-21-5p are critical in the progression of cervical cancer.
Article Synopsis
- Recent studies suggest that mA RNA modification plays a role in cervical cancer development, but more research is needed for recurrence and diagnosis prediction.
- A comprehensive analysis of 33 mA regulators identified key regulators linked to prognosis, categorizing cervical cancer patients into two clusters based on their outcomes.
- Findings showed that higher mAScores correlated with worse prognosis and indicated potential avenues for predicting the effectiveness of immunotherapy and improving treatment strategies for cervical cancer patients.
Article Synopsis
- Ovarian cancer has a high incidence and poor prognosis, with evidence showing that abnormal alternative splicing (AS) may contribute to its development.
- Researchers used public databases like TCGA to identify AS events linked to patient outcomes and created a model for prognosis prediction based on AS.
- The study found eight significant AS events that help differentiate between high-risk and low-risk groups, with the low-risk group experiencing better outcomes and increased sensitivity to paclitaxel, and developed an improved prognosis model that combines AS risk scores with clinical features.
Article Synopsis
- Emerging research shows that low oxygen levels (hypoxia) and immune response are key factors in cancer development, specifically cervical cancer (CC).
- A new hypoxia-immune-related prognostic risk model was created to help predict patient outcomes and response to treatments, using data from The Cancer Genome Atlas (TCGA).
- The study identified seven important genes linked to patient survival, finding that patients at lower risk lived longer, while those at higher risk responded better to certain chemotherapy, suggesting this model could aid in developing new treatment strategies.
An excellent aptasensor for electrochemical detection of amyloid-β oligomers (AβOs) at trace levels was fabricated based on a triple-helix aptamer switch (THAS) via target-triggered signal transduction DNA displacement events. Specifically, a single-stranded anti-AβO aptamer (Apt) carrying two symmetrical arm segments was first attached via Au-S binding to an Au electrode. Gold nanoparticle (GNP)-tagged signal transduction probes (GNP-STPs) were simultaneously hybridized with the two arm segments of the Apt, and a rigid THAS was formed on the Au electrode.
View Article and Find Full Text PDFThe aggregation of amyloid-β oligomers (AβOs) with extremely strong neurotoxicity has been proved to be the main pathogenesis of Alzheimer's disease (AD). For sensitive quantification of AβOs, a switchable electrochemical aptasensor is proposed. Metal organic framework carrying Au nanoparticles (AuNPs@CuMOF) has been used to label signaling displaced-probe (SD), which formed triple helix switch (THS) by hybridizing with label-free anti-AβOs aptamer (Apt) on the electrodeposited palladium electrode (EPd).
View Article and Find Full Text PDFBackground: Skipping breakfast is becoming common worldwide. Our previous studies showed that the breakfast prevalence was relatively low.
Methods: In three cross-sectional studies, breakfast prevalence in various populations in Inner Mongolia Medical University campus in 2011, 2013 and 2017 was investigated.