Molecular mechanisms of Chengshi Beixie Fenqing Decoction based on network pharmacology: pivotal roles of relaxin signaling pathway and its associated target proteins against Benign prostatic hyperplasia.

Benign prostatic hyperplasia (BPH) is a common disease that affects the quality of life of middle-aged and older men. We investigated the therapeutical effects of Chengshi Beixie Fenqing Decoction (CBFD), a classic traditional Chinese medicine prescription, on BPH through model and network pharmacology. Bioactives in CBFD were detected through UPLC-Q-Tof-MS/MS and GC-MS, and filtered by the modified Lipinski's rule.

Development of an Independent Prognostic Signature Based on Three Hypoxia-Related Genes for Breast Cancer.

Background: Hypoxia was considered to be a prognostic indicator in a variety of solid tumors. This study aims at identifying the hypoxia-related genes (HRGs) in breast cancer (BC) and the feasibility of HRGs as a prognostic indicator.

Methods: We downloaded the mRNA expression data of BC patients from TCGA and GEO databases.

Neferine, a novel ROCK1-targeting inhibitor, blocks EMT process and induces apoptosis in non-small cell lung cancer.

The compounds derived from Traditional Chinese Medicines have shown various pharmacological activities with unique advantages, especially in the aspect of antitumor. Neferine (Nef), a natural compound, extracted from green seed embryos of Lotus (Nelumbo nucifera Gaertn.) also exerts antitumor effects on cancers.

Quercetin promotes cutaneous wound healing in mice through Wnt/β-catenin signaling pathway.

Ethnopharmacological Relevance: Oxytropis falcata Bunge is a legume distributed in Northwest China, which is mainly used to treat knife wounds and inflammation. Quercetin is a bioactive flavonoid in O. falcata and becomes a promising healing compound for its angiogenic and anti-inflammatory activities.

Facile synthesis of a high-performance titanosilicate catalyst with controllable defective Ti(OSi)OH sites.

A novel TS-1 (TS-1S) catalyst with newly-generated defects, i.e. Ti(OSi)3OH species, which exhibits the highest reactivity among different Ti species, is constructed in an ingenious strategy.