Improved Immune Response for Colorectal Cancer Therapy Triggered by Multifunctional Nanocomposites with Self-Amplifying Antitumor Ferroptosis.

Ferroptosis, as a type of regulated cell death, can trigger the release of damage-associated molecular patterns from cancer cells and lead to the enhancement of immune recognition. Fenton reaction-mediated chemodynamic therapy could initiate ferroptosis by generating lipid peroxides, but its efficiency would be greatly restricted by the insufficient HO and antioxidant system within the tumor. Herein, this work reports the successful preparation of HO self-supplied and glutathione (GSH)-depletion therapeutic nanocomposites (CuO@Au) through in situ growth of Au nanoparticles on the surface of cuprous oxide (CuO) nanospheres.