Publications by authors named "Binghe Sun"
Article Synopsis
- BRCA1 is a critical tumor suppressor gene often mutated in ovarian and breast cancers, leading to issues in DNA repair and increased genomic instability, which can be targeted by PARP inhibitors (PARPi).
- This study reveals that BRCA1 enhances susceptibility to ferroptosis (a type of regulated cell death) by promoting the degradation of the protein GPX4, which protects cells from oxidative damage.
- The research shows that blocking GPX4 can boost the effectiveness of PARPi treatment in BRCA1-deficient ovarian cancer cells, suggesting that targeting GPX4 could be a promising therapeutic strategy for treating these cancers.
KRAS mutations are frequently detected in non-small cell lung cancers (NSCLCs). Although covalent KRAS inhibitors have been developed to treat KRAS-mutant cancers, effective treatments are still lacking for other KRAS-mutant NSCLCs. Thus, identifying a KRAS effector that confers poor prognosis would provide an alternative strategy for the treatment of KRAS-driven cancers.
View Article and Find Full Text PDFA digital spectrometer for low-field magnetic resonance imaging is described. A digital signal processor (DSP) is utilized as the pulse programmer on which a pulse sequence is executed as a subroutine. Field programmable gate array (FPGA) devices that are logically mapped into the external addressing space of the DSP work as auxiliary controllers of gradient control, radio frequency (rf) generation, and rf receiving separately.
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