Predicting osteoporotic fractures post-vertebroplasty: a machine learning approach with a web-based calculator.

Purpose: The aim of this study was to develop and validate a machine learning (ML) model for predicting the risk of new osteoporotic vertebral compression fracture (OVCF) in patients who underwent percutaneous vertebroplasty (PVP) and to create a user-friendly web-based calculator for clinical use.

Methods: A retrospective analysis of patients undergoing percutaneous vertebroplasty: A retrospective analysis of patients treated with PVP between June 2016 and June 2018 at Liuzhou People's Hospital was performed. The independent variables of the model were screened using Boruta and modelled using 9 algorithms.

Ensemble learning-assisted prediction of prolonged hospital length of stay after spine correction surgery: a multi-center cohort study.

Purpose: This research aimed to develop a machine learning model to predict the potential risk of prolonged length of stay in hospital before operation, which can be used to strengthen patient management.

Methods: Patients who underwent posterior spinal deformity surgery (PSDS) from eleven medical institutions in China between 2015 and 2022 were included. Detailed preoperative patient data, including demographics, medical history, comorbidities, preoperative laboratory results, and surgery details, were collected from their electronic medical records.

Identification of sensory dysfunction and nervous structure changes in knockout mice.

Objectives: Mutation in human gene has been implicated in hereditary sensory and autonomic neuropathy type IIB. We aimed to knock out in mice and explored its phenotypes to determine whether the genetic impairments and behavioral changes can mirror manifestations noted in humans.

Methods: We used CRISPR/Cas9 technology to knockout the gene in the C57BL/6 J mouse.

Lrpap1 deficiency leads to myopia through TGF-β-induced apoptosis in zebrafish.

Background: Frameshift mutations in LRPAP1 are responsible for autosomal recessive high myopia in human beings but its underlying mechanism remains elusive. This study aims to investigate the effect of LRPAP1 defect on ocular refractive development and its involved mechanism.

Methods: A lrpap1 mutant zebrafish line with homozygous frameshift mutation was generated by CRISPR/Cas9 technology and confirmed by Sanger sequencing.

Research on the Influence of Cosolvent on the Determination of the Contamination Degree of Jet Fuel.

The effect of cosolvent on trace free water in the determination of the contamination degree of jet fuel was investigated. The interference of trace free water on the automatic particle counter can be eliminated by adding isopropanol as a cosolvent to the measured oil sample. Isopropanol can dissolve trace free water in oil.

Posteromedial Ankle Impingement Caused by Hypertrophy of Talocalcaneal Coalition: A Report of Five Cases and Introduction of a Novel Index System.

Ankle impingement syndromes are common disorders that can be attributed to many factors. To the best of our knowledge, posteromedial ankle impingement syndromes caused by talocalcaneal coalition have never been previously reported. The present report describes 5 patients with posteromedial ankle pain and inversion limitation.