Melastoma dodecandrum lour. Protects against cerebral ischemia-reperfusion injury by ameliorating oxidative stress and endoplasmic reticulum stress.

Ethnopharmacological Relevance: Melastoma dodecandrum Lour. (MD), a traditional Chinese medicine used by the She ethnic group, has been used to treat cerebral ischemia-reperfusion (CIR) injury due to its efficacy in promoting blood circulation and removing blood stasiss; however, the therapeutic effects and mechanisms of MD in treating CIR injury remain unclear.

Aim: To investigate the protective effects of MD on CIR injury, in addition to its impact on oxidative stress, endoplasmic reticulum (ER) stress, and cell apoptosis.

Mangiferin attenuates osteoporosis by inhibiting osteoblastic ferroptosis through Keap1/Nrf2/SLC7A11/GPX4 pathway.

Background: Ferroptosis is a crucial contributor to impaired osteoblast function in osteoporosis. Mangiferin, a xanthonoid glucoside isolated from mangoes, exhibits anti-osteoporosis effects. However, its potential mechanism is not fully understood.

Yunvjian decoction attenuates lipopolysaccharide-induced periodontitis by suppressing NFκB/NLRP3/IL-1β pathway.

Ethnopharmacological Relevance: Yunvjian decoction (YNJ) is a traditional Chinese herbal prescription that has been used in the clinical treatment of periodontitis. However, the underlying molecular mechanism of YNJ in the periodontitis treatment is not well understood.

Aim Of The Study: The purpose of this study was to evaluate the therapeutic effects of YNJ against periodontitis and its underlying molecular mechanisms.

Specnuezhenide Ameliorates Age-Related Hepatic Lipid Accumulation via Modulating Bile Acid Homeostasis and Gut Microbiota in D-Galactose-Induced Mice.

Age-related hepatic lipid accumulation has become a major health problem in the elderly population. Specnuezhenide (SPN) is a major active iridoid glycoside from an edible herb , which is commonly used for preventing age-related diseases. However, the beneficial effects of SPN on age-related liver injury remain unknown.

Structural characterization and anti-osteoporosis effect of an arabinomannan from Anemarrhena asphodeloides Bge.

To discover the polysaccharide with anti-diabetic osteoporosis (DOP) activity and clarify its structure, an arabinomannan (PAAP-1B) with a molecular weight of 14.0 kDa was isolated from Anemarrhena asphodeloides Bge. using column chromatography.

Pyrolysis temperature affects the physiochemical characteristics of lanthanum-modified biochar derived from orange peels: Insights into the mechanisms of tetracycline adsorption by spectroscopic analysis and theoretical calculations.

Biochar (BC) derived from orange peels was modified using LaCl to enhance its tetracycline (TC) adsorption capacity. SEM-EDS, FT-IR, XRD, and BET were used to characterize the physiochemical characteristics of La-modified biochar (La-BC). Batch experiments were conducted to investigate the effects of several variables like pyrolysis temperature, adsorbent dosage, initial pH, and coexisting ions on the adsorption of TC by La-BC.

VDR activation attenuates osteoblastic ferroptosis and senescence by stimulating the Nrf2/GPX4 pathway in age-related osteoporosis.

Ferroptosis plays an essential role in the pathology of osteoporosis. This study investigated whether vitamin D receptor (VDR) activation could protect against age-related osteoporosis through an anti-ferroptosis mechanism. d-galactose (D-gal)-induced mice and VDR-knockout mice were used in the in-vivo study.

Effects and mechanisms of natural alkaloids for prevention and treatment of osteoporosis.

Natural alkaloids are polycyclic, nitrogen-containing, and basic compounds obtained from plants. In this review, the advances in bioactive alkaloids with respect to their chemical structures, herbal sources, and effects for the prevention and treatment of osteoporosis are discussed. Anti-osteoporosis alkaloids are classified into six categories based on the chemical structure, namely, isoquinoline alkaloids, quinolizidine alkaloids, piperidine alkaloids, indole alkaloids, pyrrolizidine alkaloids and steroidal alkaloids.

New compounds with hepatoprotective effects from the stems of .

Three new compounds, (8)-2,2,7,7-tetramethyl-8-hydroxymethyl-6-indanone-(2,3-b)-2-pyran-9-O--d-glucopyranoside (), (7,8)-2,2,7-trimethyl-7-hydroxymethyl-8-hydroxy-2,7,8,9-tetrahydro-6-naphtho-(2,3-b)-pyran-10-O--d-glucopyranoside (), 1-deoxy-1-(3,4-dihydro-7-methyl-2,3-dioxo-1(2)-quinoxalinyl)pentitol-6-carboxylic acid (3), as well as six known compounds (), were obtained. Their structures were determined by spectroscopy and comparison with NMR data of related compounds. Absolute configurations were determined by ECD spectroscopy.

attenuated vascular remodeling by alleviating endoplasmic reticulum stress in spontaneously hypertensive rats.

(CS), the leaves of S. Y. Hu.

Anti-osteoporosis effects of Anemarrhenae Rhizoma / Phellodendri Chinensis Cortex herb pair and its major active components in diabetic rats and zebrafish.

Ethnopharmacological Relevance: Anemarrhenae Rhizoma/Phellodendri Chinensis Cortex (AR/PCC) herb pair has been widely used in traditional Chinese medicines for the treatment of diabetic osteoporosis. However, the anti-diabetic osteoporotic active components of AR/PCC remain unclear. This study aimed to explore the major active ingredients in AR/PCC for its protective effects against bone deterioration induced by diabetes.

Transcriptomic and Metabolomic Profiling Reveals the Protective Effect of (Rupr. & Maxim.) Harms Combined With Blume on Cerebral Ischemia-Reperfusion Injury.

The effects of current treatment strategies used in ischemic stroke are weakened by cerebral ischemia-reperfusion (CIR) injury. Suitable treatment regimens targeting CIR injury are still lacking. Two herbs, namely, (Rupr.

Cichoric Acid Ameliorates Monosodium Urate-Induced Inflammatory Response by Reducing NLRP3 Inflammasome Activation via Inhibition of NF-B Signaling Pathway.

Gouty arthritis is characterized by the deposition of monosodium urate (MSU) within synovial joints and tissues due to increased urate concentrations. Here, we elucidated the role of the natural compound cichoric acid (CA) on the MSU crystal-stimulated inflammatory response. The THP-1-derived macrophages (THP-Ms) were pretreated with CA and then stimulated with MSU suspensions.