A singular plasmonic-thermoelectric hollow nanostructure inducing apoptosis and cuproptosis for catalytic cancer therapy.

Thermoelectric technology has recently emerged as a distinct therapeutic modality. However, its therapeutic effectiveness is significantly limited by the restricted temperature gradient within living organisms. In this study, we introduce a high-performance plasmonic-thermoelectric catalytic therapy utilizing urchin-like CuSe hollow nanospheres (HNSs) with a cascade of plasmonic photothermal and thermoelectric conversion processes.

Stretchable Unsymmetrical Piezoelectric BiO Deposited-Hydrogel as Multimodal Triboelectric Nanogenerators for Biomechanical Motion Harvesting.

Enhancing the output performance of triboelectric nanogenerators (TENGs) is essential for increasing their application in smart devices. Oxygen-vacancy-rich BiO nanosheets (BiO NSs) are advanced-engineered nanomaterials with excellent piezoelectric properties. Herein, a stretchable unsymmetrical BiO NSs deposited-hydrogel made of polyacrylamide (PAM) as a multimodal TENG is rationally fabricated, and the performance of TENG can be tailored by controlling the BiO NSs deposition amount and spatial distribution.

Anti-Freezing and Ultrasensitive Zwitterionic Betaine Hydrogel-Based Strain Sensor for Motion Monitoring and Human-Machine Interaction.

Ultrasensitive and reliable conductive hydrogels are significant in the construction of human-machine twinning systems. However, in extremely cold environments, freezing severely limits the application of hydrogel-based sensors. Herein, building on biomimetics, a zwitterionic hydrogel was elaborated for human-machine interaction employing multichemical bonding synergies and experimental signal analyses.

Bergenin attenuates bleomycin-induced pulmonary fibrosis in mice via inhibiting TGF-β1 signaling pathway.

Idiopathic pulmonary fibrosis (IPF) is a progressive lung disease characterized by epithelial cell damage, fibroblast activation, and collagen deposition. IPF has high mortality and limited therapies, which urgently needs to develop safe and effective therapeutic drugs. Bergenin, a compound derived from a variety of medicinal plants, has demonstrated multiple pharmacological activities including anti-inflammatory and anti-tumor, also acts as a traditional Chinese medicine to treat chronic bronchitis, but its effect on the pulmonary fibrosis is unknown.