Publications by authors named "BingYan Wang"

Background: Lymphatic metastasis commonly occurs in patients with papillary thyroid carcinoma and medullary thyroid carcinoma. The clinical and imaging characteristics of recurrent laryngeal nerve (RLN) invasion by extranodal extension (ENE) of metastatic lymph nodes remain understudied. This study aimed to evaluate these characteristics in patients with thyroid carcinoma.

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Periodontitis disproportionately affects genetic ancestral/ethnic groups. To characterize the oral microbiome from different genetic ancestral/ethnic groups, we collected 161 dental plaque samples from self-identified African Americans (AAs), Caucasian Americans (CAs), and Hispanic Americans (HAs) with clinical gingival health or biofilm-induced gingivitis on an intact periodontium. DNA was extracted from these samples, and then DNA libraries were prepared and sequenced using an Illumina NovaSeq high-throughput sequencer.

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Objectives: The US Food and Drug Administration (FDA) issued a warning about buprenorphine-induced dental caries of unknown mechanism in 2022. To investigate the potential mechanism, the association between local buprenorphine exposure and dental biofilm formation will be explored in this study.

Methods: Female F344 rats were dosed with sublingual buprenorphine film or intravenous injection to explore the oral cavity exposure of the buprenorphine.

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In order to improve the stability of the pulse, realize the high requirements of the direct drive ignition design for the uniformity of the target irradiation, reduce the interference of laser plasma instability, and improve the laser-target coupling efficiency, a nanosecond laser spatial-temporal modulation of high-power laser driver for double-cone ignition (DCI) research was proposed. Under the premise of satisfying the near-isentropic compression waveform of driving implosion, the time-power curves of all sub-beams in the facility are redistributed to reduce the waveform contrast ratio of each sub-beam. A fewer number of sub-beams are utilized to generate low-power foot pulses, which are focused on the target surface of the initial radius.

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Background: This study aimed to optimize a lateral transthyroid approach by using high-resolution ultrasonography (HRUS) for recurrent laryngeal nerve (RLN) visualization.

Patients And Methods: In this prospective study of 85 patients undergoing thyroidectomy, the RLN was visualized preoperatively by using a lateral transthyroid approach via HRUS. The inferior thyroid artery, thyroid nodule, and cricoid cartilage were used as landmarks.

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Article Synopsis
  • SKLB1028 is a new protein kinase inhibitor being tested to treat a specific type of leukemia (FLT3-ITD mutated acute myeloid leukemia), and its metabolism was studied in clinical trials.* -
  • Three studies were conducted with healthy male participants to analyze how other medications (itraconazole, gemfibrozil, and rifampin) affect the metabolism of SKLB1028, focusing on dosage and interaction effects.* -
  • Results showed that itraconazole and gemfibrozil increased SKLB1028's exposure in the body, while rifampin decreased it; all drug combinations were well tolerated by participants.*
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Introduction: The human-derived amnion-chorion membrane (ACM) has endogenous antimicrobial properties, which are important for preventing the colonization and survival of oral bacteria on exposed membranes. This project aimed to decipher the underlying mechanism by identifying the components of ACM that confer antibacterial properties. In addition, the antimicrobial efficacy of these identified components on oral bacteria was assessed.

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Periodontitis disproportionately affects racial/ethnic populations. Besides social determinants contributing to disparities in periodontal health, variations of oral microbial communities may also be a key factor influencing oral immune responses. To characterize the oral microbiome from different racial/ethnic populations, we collected 161 dental plaque samples from African Americans (AAs), Caucasian Americans (CAs), and Hispanic Americans (HAs) with clinical gingival health or biofilm-induced gingivitis on an intact periodontium.

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The occurrence of black gill syndrome (BGS) is a serious threat to the healthy culture of Eriocheir sinensis. Studying the innate immune ability of E. sinensis with BGS can help develop new strategies for disease prevention and treatment.

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Article Synopsis
  • Researchers identified a new FOXO gene, MnFOXO, from the shrimp Macrobrachium nipponense, which plays a crucial role in the immune response against viruses.
  • The MnFOXO gene is 2086 base pairs long and encodes a protein involving five low-complexity regions and a DNA-binding domain, with higher expression in the intestine and eyestalks.
  • Knocking down MnFOXO leads to increased expression of a viral protein and inhibits the production of critical antiviral factors (Dicers and Argonautes), showing that MnFOXO is important for antiviral responses in crustaceans.
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Purpose: This study aimed to evaluate fetal left ventricular function (LVF) in pregnant women with obstetric antiphospholipid syndrome (OAPS) by Doppler ultrasound and developed a clinical nomogram to predict adverse perinatal outcomes.

Methods: In this prospective observational study, 105 pregnant women were enrolled and divided into the OAPS cohort (n = 60) and the control cohort (n = 45). Fetal cardiac function parameters were collected and compared between two cohorts.

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  • Acute lymphoblastic leukemia (ALL) includes B-cell and T-cell subtypes, with T-cell ALL (T-ALL) being particularly challenging due to high relapse rates and limited long-term survival, even with advanced treatments like chemotherapy and stem cell transplants.
  • The review discusses the development and limitations of existing treatments for T-ALL and highlights the potential of chimeric antigen receptor (CAR) technology as a new strategy to improve outcomes.
  • It specifically examines the advancements in CAR-T and CAR-NK cell therapies, their effectiveness against T-ALL, optimization methods, and the challenges faced in clinical applications.
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This study reports the design, synthesis, and comprehensive biological evaluation of 13 benzodioxolane derivatives, derived from the core structure of piperine, a natural product with established antitumor properties. Piperine, primarily found in black pepper, has been noted for its diverse pharmacological activities, including anti-inflammatory, antioxidant, and anticancer effects. Leveraging piperine's antitumor potential, we aimed to enhance its efficacy through structural modifications.

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  • This study examines a new catheter-based technique using nanosecond pulsed electric fields for cardiac ablation in pigs, focusing on its effectiveness at targeting both cell membranes and intracellular organelles.
  • The research involved 25 pigs, assessing the impact of different ablation durations (low-dose and high-dose) on various heart sites, with evaluations conducted over various survival periods.
  • Results showed that all targeted veins were successfully isolated, lesion depth was significant, and while there were some transient effects on the phrenic nerve and esophagus, most animals healed well over time with minimal long-term damage.
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Background: The occurrence of bone metastasis (BM) will seriously shorten the survival time of lung adenocarcinoma patients and aggravate the suffering of patients. Computed tomography (CT)-based clinical radiomics nomogram may help clinicians stratify the risk of BM in lung adenocarcinoma patients, thereby enabling personalized individualized clinical decision making.

Methods: A total of 501 patients with lung adenocarcinoma from March 2017 to March 2019 were enrolled in the study.

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Myocardial infarction (MI) in mice is a widely used surgical model in preclinical cardiac repair studies to recapitulate human cardiovascular ischemic disease. Induction of reproducible infarct size is crucial for quantitative and analytical purpose. Here we describe a quick and reliable method to induce consistent infarct size in mice in less than a minute.

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Purpose: To evaluate the performance of CT-based intratumoral, peritumoral and combined radiomics signatures in predicting prognosis in patients with osteosarcoma.

Methods: The data of 202 patients (training cohort:102, testing cohort:100) with osteosarcoma admitted to the two hospitals from August 2008 to February 2022 were retrospectively analyzed. Progression free survival (PFS) and overall survival (OS) were used as the end points.

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  • Periodontitis is identified as a disease caused by an imbalance in oral bacteria, specifically needing certain harmful pathogens to thrive, and the study focuses on how specific bacteria interact in this context.
  • Researchers collected dental plaque from periodontitis patients, categorizing it based on the ratios of certain bacteria, revealing that those with a lower ratio had greater microbial diversity and different antibiotic resistance profiles.
  • The findings suggest that manipulating these bacterial ratios could help manage and potentially revise the unhealthy oral microbiome associated with periodontitis, which is important given its links to other serious health issues.
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Conductive hydrogels, especially polysaccharide-based ionic conductive hydrogels, have received increasing interest in the field of wearable sensors due to their similarity to human skin. Nevertheless, it is still a challenging task to simultaneously prepare a self-healed and adhesive conductive hydrogel with good toughness, temperature tolerance and high sensing performance, especially with high sensitivity and a low detection limit. Herein, we developed a new strategy to improve the toughness and sensing performance of a multifunctional conductive hydrogel by simultaneously using dissolved chitosan (CS) and solid chitosan nanofibers (CSFs) to induce the formation of hierarchical polymeric networks in the hydrogel.

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Liquid metal (LM) microdroplets have garnered significant interest as conductive materials for initiating free radical polymerization in the development of conductive hydrogels suited for strain sensors. However, crafting multi-functional conductive hydrogels that boast both high stretchability and superior sensing capabilities remains as a challenge. In this study, we have successfully synthesized LM-based conductive hydrogels characterized by remarkable stretchability and sensing performance employing acrylic acid (AA) to evenly distribute chitosan nanofibers (CSFs) and to subsequently catalyze the free radical polymerization of AA.

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Background: Ultrastructural findings immediately after pulsed field ablation (PFA) of the myocardium have not been described.

Objectives: The purpose of this study was to elucidate ultrastructural characteristics and differences between microsecond PFA at the 1- and 4-hour timepoints after pulse delivery and to compare them to irrigated radiofrequency ablation (RFA) lesions.

Methods: Healthy swine underwent endocardial PFA or RFA followed by necropsy.

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Background: The prognostic value of tumor size in colon cancer remains controversial. This study aimed to reveal the correlation between tumor size and prognosis of colon cancer.

Methods: A total of 491 patients with colon cancer were included in this study.

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Inflammatory pain is a common type of pathological pain. Although the dorsal root ganglion (DRG) is key to pathogenesis of inflammatory pain, the underlying specific molecular and cellular mechanisms remain unclear. In this study, we used mouse models of acute or chronic inflammatory pain, induced by formalin or complete Freund' s adjuvant (CFA), respectively, to explore whether tyrosine kinase receptor ErbB4 participates in the pathogenesis of inflammatory pain.

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Background: The novel coronavirus pneumonia (COVID-19) is an infectious disease caused by the infection of a novel coronavirus known as Severe Acute Respiratory Syndrome Coronavirus 2 (SARS-CoV-2), which has resulted in millions of deaths. We aimed to evaluate the safety and immunogenicity of the COVID-19 mRNA vaccine (CS-2034, CanSino, Shanghai, China) in adults without COVID-19 infection from China.

Method: This is a multicenter Phase I clinical trial with a randomized, double-blinded, dose-exploration, placebo-controlled design.

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