Risk classification for non-cancer death in middle-aged cancer patients.

Introduction: Non-cancer events are important causes of competing mortality among cancer patients. However, the risk of non-cancer death and risk classification in middle-aged cancer patients is not clear. To comprehensively analyze the risk of non-cancer deaths in 24 different cancers among middle-aged patients.

PD-1/PD-L1 and coronary heart disease: a mendelian randomization study.

Introduction: It has been found that programmed cell death protein-1 (PD-1) or its ligand PD-L1 may play an important role in the onset and progression of coronary heart disease (CHD). Thus, we conducted this mendelian randomization analysis (MR) to estimate the causal relationship between PD-1/PD-L1 and 5 specific CHDs (chronic ischemic heart disease, acute myocardial infarction, angina pectoris, coronary atherosclerosis, and unstable angina pectoris), complemented by gene set enrichment analysis (GSEA) for further validation.

Methods: Publicly available summary-level data were attained from the UK Biobank with genetic instruments obtained from the largest available, nonoverlapping genome-wide association studies (GWAS).

Causal impact of human blood metabolites and metabolic pathways on serum uric acid and gout: a mendelian randomization study.

Objective: Hyperuricaemia and gout are common metabolic disorders. However, the causal relationships between blood metabolites and serum urate levels, as well as gout, remain unclear. A systematic evaluation of the causal connections between blood metabolites, hyperuricemia, and gout could enhance early screening and prevention of hyperuricemia and gout in clinical settings, providing novel insights and approaches for clinical treatment.

Unveiling the Etiology of Urological Tumors: A Systematic Review of Mendelian Randomization Applications in Renal Cell Carcinoma, Bladder Cancer, and Prostate Cancer.

Background: Our study aims to address two pivotal questions: "What are the recent advancements in understanding the etiology of urological tumors through Mendelian Randomization?" and "How can Mendelian Randomization be more effectively applied in clinical settings to enhance patient health outcomes in the future?"

Methods: In our systematic review conducted in April 2023, we utilized databases like PubMed and Web of Science to explore the influence of Mendelian Randomization in urological oncological diseases. We focused on studies published from January 2018, employing keywords related to urological tumors and Mendelian Randomization, supplemented with MeSH terms and manual reference checks. Our inclusion criteria targeted original research studies, while we excluded reports and non-relevant articles.

Visualizing pursed lips breathing of patients with chronic obstructive pulmonary disease through evaluation of global and regional ventilation using electrical impedance tomography.

. This study aims to explore the possibility of using electrical impedance tomography (EIT) to assess pursed lips breathing (PLB) performance of patients with chronic obstructive pulmonary disease (COPD)..

Diagnostic performance of a multiplexed gastrointestinal PCR panel for identifying diarrheal pathogens in children undergoing hematopoietic stem cell transplant.

Background: Diarrhea is a common complication of hematopoietic stem cell transplantation (HSCT) and is associated with substantial morbidity, but its etiology is often unknown. Etiologies of diarrhea in this population include infectious causes, chemotherapy- or medication-induced mucosal injury and graft-versus-host disease (GVHD). Distinguishing these potential causes of diarrhea is challenging since diarrheal symptoms are often multifactorial, and the etiologies often overlap in transplant patients.

Accuracy of digital implant impressions obtained using intraoral scanners: a systematic review and meta-analysis of in vivo studies.

Purpose: This systematic review aimed to investigate the accuracy of intraoral scan (IOS) impressions of implant-supported restorations in in vivo studies.

Methods: A systematic electronic search and review of studies on the accuracy of IOS implant impressions were conducted to analyze the peer-reviewed literature published between 1989 and August 2023. The bias analysis was performed by two reviewers.

A novel biochemistry approach combined with MALDI-TOF MS to discriminate Escherichia coli and Shigella species.

Escherichia coli and Shigella spp. are closely related, making it crucial to accurately identify them for disease control and prevention. In this study, we utilized MALDI-TOF MS to identify characteristic peaks of decarboxylation products of lysine and ornithine to distinguish between E.

Epidemiological and clinical characteristics of a family cluster of psittacosis: A case report.

Psittacosis accounts for 1-2 % of community-acquired pneumonia. In recent years, reports of psittacosis are increasing. Most reported cases of psittacosis are sporadic.

BuShen JianGu Fang alleviates cartilage degeneration via regulating multiple genes and signaling pathways to activate NF-κB/Sox9 axis.

Background: Osteoarthritis (OA) is an inflammatory response in chondrocytes, causing extracellular matrix (ECM) degradation and cartilage destruction, affecting millions of people worldwide. Chinese herbal formulae BuShen JianGu Fang (BSJGF) has been clinically applied for treating OA-related syndromes, but the underlying mechanism still unclear.

Methods: The components of BSJGF were analyzed by liquid chromatography-mass spectrometry (LC-MS).

Configuration of prosocial motivations to enhance employees' innovation behaviors: From the perspective of coupling of basic and applied research.

Prosocial motivation refers to the employees' willingness to invest for the sake of helping others. It improves basic and applied research behaviors of employees and the interaction between them. Employees' innovation behavior depends on prosocial motivation because the motivation to protect the interests of others may promote knowledge sharing and knowledge coupling.

Evaluation of the effectiveness and safety of icariin in the treatment of knee osteoarthritis: A protocol for a systematic review and meta-analysis.

Background: Knee osteoarthritis (KOA) is a chronic degenerative disease involving cartilage and surrounding tissues. It causes a huge burden to social and medical resources and seriously affects people's living and working ability. In recent years, people have become increasingly interested in the application of Chinese medicine monomers to treat KOA.

Predicting the potential global distribution of under current and future climate change scenarios.

Aim: Invasive alien species (IAS) threaten ecosystems and humans worldwide, and future climate change may accelerate the expansion of IAS. Predicting the suitable areas of IAS can prevent their further expansion. is an invasive weed over 30 countries in tropical and subtropical regions.

Opioid Receptor Agonist Inhibits Myocardial Injury in Heart Failure Rats through Activating Nrf2/HO-1 Pathway and Regulating Ca-SERCA2a.

Objectives: We aimed to observe the protective effect of opioid receptor (-OR) agonist on myocardial injury in heart failure (HF) rats and its effect on Ca-SERCA2a and to explore the regulatory mechanism with the Nrf2/HO-1 signaling pathway.

Methods: 50 Sprague-Dawley rats were randomly divided into the following groups: the sham operation group (sham group), HF model group (HF group), HF+-OR agonist U50488 group (HU group), HF+U50488H+novel calmodulin-dependent protein kinase II (CaMKII) agonist (oleic acid) (HUO group), and HF+U50488H+Nrf2 inhibitor (HUM group). The HF rat's model was established through surgical ligation of the left anterior descending coronary artery and the exhausting swimming exercise.

Novel Strategy for Rapidly and Safely Distinguishing Bacillus anthracis and Bacillus cereus by Use of Peptide Mass Fingerprints Based on Matrix-Assisted Laser Desorption Ionization-Time of Flight Mass Spectrometry.

The objective of this study was to construct a rapid, high-throughput, and biosafety-compatible screening method for and based on matrix-assisted laser desorption ionization-time of flight mass spectrometry (MALDI-TOF MS). MALDI-TOF MS coupled to ClinProTools was used to discover MALDI-TOF MS biomarker peaks and generate a classification model based on a genetic algorithm (GA) to differentiate between different and isolates. Thirty and 19 strains were used to construct and analyze the model, and 40 strains were used for validation.

Farmland abandonment and its determinants in the different ecological villages of the Koshi river basin, central Himalayas: Synergy of high-resolution remote sensing and social surveys.

Globally, there is a noticeable increasing trend in farmland abandonment, which directly affects farmers' livelihood and food security. The abandonment status, its determinants and impact vary by spatial and socioeconomic context. In order to study this important issue, we selected three different villages representing three ecological regions (Mountain, Hill, and Tarai) in the Koshi River Basin (KRB), and applied two methods: the Unmanned Aerial Vehicle (UAV) and a social survey.

Increasing sensitivity of alpine grasslands to climate variability along an elevational gradient on the Qinghai-Tibet Plateau.

Monitoring and mapping the sensitivity of grassland ecosystems to climate change is crucial for developing sustainable local grassland management strategies. The sensitivity of alpine grasslands to climate change is considered to be high on the Qinghai-Tibet Plateau (QTP), yet little is known about its spatial pattern, and particularly the variations between different elevations. Here, based on the Normalized Difference Vegetation Index (NDVI) and three climate variables (air temperature, precipitation, and solar radiation), we modified a vegetation sensitivity index-approach to capture the relative sensitivity of alpine grassland productivity to climate variability on the QTP during 2000-2016.

Current challenges in distinguishing climatic and anthropogenic contributions to alpine grassland variation on the Tibetan Plateau.

Quantifying the impact of climate change and human activities on grassland dynamics is an essential step for developing sustainable grassland ecosystem management strategies. However, the direction and magnitude of climate change and human activities in driving alpine grassland dynamic over the Tibetan Plateau remain under debates. Here, we systematically reviewed the relevant studies on the methods, main conclusions, and causes for the inconsistency in distinguishing the respective contribution of climatic and anthropogenic forces to alpine grassland dynamic.

Ultrasonic-Assisted Dispersion of ZnO Nanoparticles and Its Inhibition Activity to .

The activity inhibition of fungi by ZnO nanoparticles (NPs) has shown huge potential applications in the area of hygienic coatings. However, the inhibition efficiency was limited due to the agglomeration of NPs. To obtain well-dispersed and highly stabilized ZnO nanofluids, ZnO NPs were capped with four kinds of surfactants under ultrasonication.

Changes in body composition in children with acute graft-versus-host disease within the first 100 days after hematopoietic stem cell transplantation.

Background: Acute graft-versus-host-disease (aGVHD) is one of the main complications of hematopoietic stem cell transplantation (HSCT). This study investigated the changes in body composition of pediatric patients with aGVHD during the first 100 days after HSCT.

Methods: Fifty-five children receiving HSCT were divided into two groups (aGVHD and non-aGVHD).