Publications by authors named "Bing-xiu Xiao"
Non-coding RNAs (ncRNAs) play key roles in development, proliferation, differentiation and apoptosis. Altered ncRNA expression is associated with gastric cancer occurrence, invasion, and metastasis. Moreover, aberrant expression of microRNAs (miRNAs) is significantly related to gastric cancer tumor stage, size, differentiation and metastasis.
View Article and Find Full Text PDFLong non-coding RNAs (lncRNAs) play biological roles through a variety of mechanisms, including genetic imprinting, chromatin remodeling, cell cycle control, splicing regulation, mRNA decay, and translational regulation. LncRNAs are involved in the regulation of gene expression through the above mechanisms in different levels. Establishment and application of research technologies are important in understanding of lncRNAs functions.
View Article and Find Full Text PDFArticle Synopsis
- The study investigates how 4-phenyl butyric acid (PBA) affects the growth of human gastric cancer cells and the underlying mechanisms involved.
- Human gastric carcinoma cell lines SGC-7901 and MGC-803 were treated with varying concentrations of PBA, and their proliferation and cell cycle distributions were analyzed.
- Results indicated that PBA inhibits cancer cell growth in a dose- and time-dependent manner, causing different cell cycle arrests: SGC-7901 at G₀/G₁ and G₂/M phases, and MGC-803 at G₀/G₁ and S phases.
Background: Piwi-interacting RNAs (piRNAs) are a novel class of non-coding single strand RNAs. They are involved in germline development, in silencing of selfish DNA elements, and in maintaining germline DNA integrity. The relationship between piRNAs and carcinogenesis has not been shown yet.
View Article and Find Full Text PDFProfilin-1 has recently been linked to vascular hypertrophy and remodeling. Here, we assessed the hypothesis that angiotensin (Ang) II type I receptor antagonist telmisartan improves vascular hypertrophy by modulation of expression of profilin-1 and angiotensin-converting enzyme 2 (ACE2). Ten-week-old male spontaneously hypertensive rats (SHR) were received oral administration of telmisartan (5 or 10mg/kg; daily) or saline for 10 weeks.
View Article and Find Full Text PDF[Effect of microRNA on proliferation of human tongue carcinoma Tca8113 cells].
Zhonghua Kou Qiang Yi Xue Za Zhi
March 2010
Objective: To investigate the effects of microRNA (miRNA) on proliferation of cultured human squamous cell carcinoma of tongue Tca8113 cells.
Methods: The mimics or inhibitors of miRNA-31 or miRNA-139 were transfected into Tca8113 cells using liposome. Tca8113 cell proliferation was detected by 3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyl tetrazolium bromide (MTT) assay.
Recently, the detection of occult cancer cells in peripheral blood has received a great deal of attention regarding the prediction of postoperative cancer recurrence and for novel strategies of adjuvant therapy. The aim of this study was to establish a new molecular diagnostic method of detecting circulating tumor cells. Gastric cancer SGC-7901 cells in 2 ml blood from healthy volunteers were serially diluted.
View Article and Find Full Text PDF[The anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanism].
Zhonghua Kou Qiang Yi Xue Za Zhi
January 2009
Objective: To investigate the anti-proliferation and anti-migration dual effects of aloe-emodin on KB cells and its mechanisms.
Methods: KB cells were treated with 2.5, 5, 10, 20 and 40 micromol/L aloe-emodin.
Aim: The aim of this study was to investigate the effects of aloe-emodin, a natural compound from the root and rhizome of Rheum palmatum, on the growth of human cervical cancer cells, HeLa.
Methods: HeLa cells were treated with various concentrations of aloe-emodin for 1-5 d, and cell growth was measured by 3-(4, 5-dimethylthiazol-2-yl)-2, 5-diphenyl tetrazolium bromide assay. The long-term growth effect was investigated by crystal violet assay.
Background: The low frequency of disseminated carcinoma cells in the blood now makes immunomagnetic bead sorting and reverse transcriptase-polymerase chain reaction (RT-PCR) technique more popular.
Methods: Three milliliters of peripheral blood were collected from 91 patients and 18 normal donors. The circulating carcinoma cells were enriched with CD45 and Ber-EP4 immunomagnetic beads.
Gene is a DNA sequence which can be expressed and produces gene products (protein or RNA). By 2003, there are 51 Nobel Prize owners related to gene studies. Among them, 44 persons are in physiology or medicine (account for 24.
View Article and Find Full Text PDFAim: To study the effects of daidzein on human pancreatic cancer cells in vitro.
Methods: Human estrogen-receptor (ER)-positive pancreatic cancer cells MiaPaCa-2 and ER-negative pancreatic cancer cells PANC-1 were treated by 0.1 micromol/L, 1 micromol/L, 10 microL, 25 microL, 50 microL, 75 microL and 100 microL of daidzein, respectively.