[Association of polymorphism on HLA-DRB1*04 alleles with outcome of hepatitis B virus infection].

Objective: To investigate the relation between the alleles of HLA-DRB1*04 and outcome of HBV infection.

Methods: The alleles of HLA-DRB1*04 were detected by polymerase chain reaction-sequence specific primer (PCR-SSP). The frequency of allele of HLA-DRB1*04 in four groups[106 asymptomatic HBsAg carriers (group ASC), 93 chronic hepatitis B patients (group CHB), 77 patients with hepatitis B cirrhosis and 102 cases of spontaneous recovery after HBV infection (control group)] were studied, and the frequency of that in different replication of HBV was also studied.