Prognostic Impact of Neoadjuvant Chemotherapy in Localized or Locoregionally Advanced Gallbladder Cancer: A Population-Based and Propensity Score Matched SEER Analysis.

Background: The effect of neoadjuvant chemotherapy (NACT) in gallbladder cancer (GBC) patients remains controversial. The aim of this study was to assess the impact of NACT on overall survival (OS) and cancer specific survival (CSS) in patients with localized or locoregionally advanced GBC, and to explore possible protective predictors for prognosis.

Methods: Data for patients with localized or locoregionally advanced GBC (i.

[Changes in expressions of sRNA SpR19 and its potential target GroEL in Streptococcus mutans strains with different cariogenicity cultured under different pH conditions].

Objective: To investigate the changes in the expression level of sRNA SpR19 and its potential target protein GroEL in clinical isolates of Streptococcus mutans with different cariogenicity exposed to different pH conditions and explore the possibility of using these molecules as biomarkers for assessing the cariogenicity of the bacteria.

Methods: The total RNAs were extracted from the clinical isolates of Streptococcus mutans with high (strain 17) and low cariogenicity (strain 5) for high-throughput sequencing for profiling of the differentially expressed sRNAs. The candidate sRNA, SpR19, was selected for further study on the basis of bioinformatics analysis considering the role of its potential target in the cariogenic process.

Downregulation of Notch-regulated Ankyrin Repeat Protein Exerts Antitumor Activities against Growth of Thyroid Cancer.

Background: The Notch-regulated ankyrin repeat protein (NRARP) is recently found to promote proliferation of breast cancer cells. The role of NRARP in carcinogenesis deserves extensive investigations. This study attempted to investigate the expression of NRARP in thyroid cancer tissues and assess the influence of NRARP on cell proliferation, apoptosis, cell cycle, and invasion in thyroid cancer.

B7-H4 expression is associated with cancer progression and predicts patient survival in human thyroid cancer.

Objective: This study aimed to investigate the expression of B7-H4 in human thyroid cancer and determine any association with patient clinicopathological parameters and survival.

Methods: B7-H4 expression in 64 clinical thyroid cancer specimens was assessed with immunohistochemistry. Moreover, B7-H4 mRNA expression in 10 fresh resected specimens were evaluated by the reverse transcription-polymerase chain reaction (RT-PCR).

Aging performances for resisting low-temperature of three dental Yttria-stabilized zirconia ceramic core materials.

Background: The low-temperature resistance aging performance of Yttria-stabilized tetragonal zirconia polycrystal (Y-TZP) is the key effective factor that influences the long-term success rate of prosthesis. The objective of this study was to test and compare the aging performances for resisting low temperature of Lava Frame, Cercon Smart, and Upcera Yttria-stabilized zirconia core materials, via analyzing the micro and the crystal phases of the materials, and measure the three-point bending strength and the fracture toughness.

Methods: The three zirconia green bodies were prepared as 60 test samples for three-point bending strength and as 60 test samples for fracture toughness.

[Minimal intervention dentistry: a vision of caries management for older patients. II].

Minimal intervention dentistry (MID) is a new approach to caries management in older patients, which emphasize on early discussion, early diagnosis and early treatment. It focuses on stopping the disease process and patient-friendly surgical intervention only when required. Geriatric MID can improve oral ecological balance, lower caries risk, reverse dental caries process and reduce the pain when surgical intervention required.

[Three-dimensional accuracy of plaster casts obtained using three impression materials].

Objective: To evaluate the accuracy of 3 impression materials in reproductions of simian dental arches using a 3-dimensional optical digitizer.

Methods: Two simian dental arches were prepared as the master models. Impressions were made for stone casts using three impression materials, including alginate impression materials, C-silicone materials and Impregum-Penta polyether rubber.

[Minimal intervention dentistry: a vision of caries management for older patients. I].

The ageing of Chinese population combined with development of geriatric dentistry results in increased retention of natural teeth and higher risk of dental caries in older patients. This means new challenge for clinicians. Minimal intervention dentistry (MID) is a new approach to caries management in older patients, which emphasize on early discussion, early diagnosis and early treatment.

[Inhibition effect of methylene blue on the acids production of Streptococcus mutans].

Objective: To study the effect of methylene blue on the growth and acid production of Streptococcus mutans, and the effect of methylene blue on acid production metabolism in plaque glycolysis model (i-PGM) in vitro, and investigate the practicability of methylene blue as a new kind of dental caries prevention agent.

Methods: Nephelometer method was used to measure OD value of Streptococcus mutans culture fluid in the different incubation conditions. The kinds and quantities of acid produced by Streptococcus mutans in the different incubation conditions were measured with gas chromatography.