Publications by authors named "Bing-Zhi Wang"
The rapid, sensitive, and accurate detection of paralytic shellfish toxins (PSTs), such as saxitoxin (STX), is critical for protecting human health due to the frequent occurrence of toxic red tides. In this work, to address the low affinity of traditional mouse monoclonal antibodies (m-mAbs), rabbit monoclonal antibodies (r-mAbs) against STX were produced by a single B-cell sorting culture and a cross-selection strategy. The r-mAbs showed 100-fold improvement in sensitivity (IC = 0.
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- Excessive pesticide use threatens food safety, making rapid detection of pesticide residues in vegetables critical due to their short shelf life.
- A new screening method was developed using a compact mass spectrometer, which involves mixing vegetables with an elution solution in a special ziplock bag, allowing for efficient residue removal in just 2 minutes with minimal solvents.
- The study also introduced a deep learning algorithm that improves detection accuracy to 99.62%, enabling on-site quantitative analysis of pesticide levels, highlighting its potential for enhancing food safety.
Article Synopsis
- Chemotherapy and gastrojejunostomy are key treatments for patients with unresectable gastric cancer and gastric outlet obstruction (GOO), with radical surgery reserved for those responding to chemotherapy.
- This case study details the successful use of a modified laparoscopic technique to relieve GOO and perform radical resection after a positive chemotherapy response in a patient with advanced gastric cancer.
- The findings suggest that laparoscopic stomach-partitioning gastrojejunostomy combined with lymph node dissection can be an effective approach for managing initially unresectable gastric cancer.
Background: Tumour-infiltrating lymphocytes (TILs) represent a robust biological prognostic biomarker in triple-negative breast cancer (TNBC); however, the contribution of different subsets of immune cells is unclear. We investigated the prognostic value of immune markers, including stromal TILs (sTILs), CD8T and FOPX3T cells, PD-1 and PD-L1 in non-metastatic TNBC.
Methods: In total, 259 patients with Stage I-III TNBC were reviewed.
Background: Bladder cancer (BC) is the most common malignant tumor of the urinary system. Gemcitabine resistance partly accounts for treatment failure and recurrence in BC. Immunological cell death (ICD) is correlated with chemoresistance.
View Article and Find Full Text PDFBackground: Epstein-Barr virus-associated gastric cancer (EBVaGC) exhibits unique histological characteristics within the immune-cell-rich microenvironment, but the role of tertiary lymphoid structure (TLS) in EBVaGC is not yet fully understood.
Methods: We retrospectively identified EBVaGC from 8517 consecutive GC cases from the two top cancer centers in China. Furthermore, we evaluated the prognostic value of TLS in 148 EBVaGC patients from our institute and then validated it in an external cohort (76 patients).
Background: The addition of immune checkpoint inhibitors to perioperative chemotherapy in operable gastric or gastroesophageal junction (GEJ) cancer has become one of the research hotspots, while reliable biomarkers for efficacy are lacking. We conducted a phase 1 trial to assess the safety and efficacy of LP002, an anti-PD-L1 antibody, plus chemotherapy as perioperative treatment in patients with gastric or GEJ cancer.
Methods: We enrolled patients with resectable and PD-L1 positive gastric or GEJ cancers.
Background: The prognosis of gastric cancer in an advanced stage remains poor. The exact efficacy of the use of intraoperative sustained-release chemotherapy with 5-fluorouracil (5-FU) in advanced-stage gastric cancer is still unelucidated.
Aim: To explore the long-term survival benefit of using sustained-release 5-FU implants in stage II and stage III gastric cancer patients.
Background: For Siewert type II/III adenocarcinoma of gastroesophageal junction (AGE), the efficacy of adjuvant chemoradiotherapy (CRT) after D2/R0 resection remains uncertain.
Aim: To determine whether CRT was superior to chemotherapy (CT) alone after D2/R0 resection for locally advanced Siewert type II/III AGE.
Methods: We identified 316 locally advanced Siewert type II/III AGE patients who were treated with D2/R0 resection at National Cancer Center from 2011 to 2018.
Can Gastric Cancer Patients with High Mandard Score Benefit from Neoadjuvant Chemotherapy?
Can J Gastroenterol Hepatol
April 2022
A high Mandard score may indicate the tumor is insensitive to chemotherapy. We analyzed tumor regression and lymph node response under different Mandard scores to assess the impact of Mandard score on prognosis. .
View Article and Find Full Text PDFDiazinon (DAZ) is an organophosphorus pesticide (OP), which is commonly used to prevent and control harmful pests that endanger agricultural products. In this study, we developed a novel heterology coating strategy for the immunoassay of DAZ. The DAZ coating hapten can be directly conjugated to the carrier protein without requiring a spacer arm.
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