Publications by authors named "Bing-Yao Zhou"
Article Synopsis
- Research shows a link between the ULK4 gene and schizophrenia (SCZ), but effects on animal behavior due to ULK4 deficiency were previously unexplored.
- * Scientists created mice lacking the ULK4 gene in certain brain neurons and found changes in memory and sensorimotor functions, alongside altered signaling pathways.
- * The study suggests that ULK4 impacts cognitive functions and its malfunction may contribute to schizophrenia-like behaviors in mice.
PTEN is known as a tumor suppressor and plays essential roles in brain development. Here, we report that PTEN in primary sensory neurons is involved in processing itch and thermal information in adult mice. Deletion of PTEN in the dorsal root ganglia (DRG) is achieved in adult Drg11-Cre: PTEN (PTEN CKO) mice with oral administration of tamoxifen, and CKO mice develop pathological itch and elevated itch responses on exposure to various pruritogens.
View Article and Find Full Text PDF3-Phosphoinositide-dependent protein kinase-1 (PDK1) plays a critical role in the development of mammalian brain. Here, we investigated the role of PDK1 in Purkinje cells (PCs) by generating the PDK1-conditional knock-out mice (cKO) through crossing or mice with mice. The male mice were used in the behavioral testing, and the other experiments were performed on mice of both sexes.
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