Cerebral Metabolic Profiling of Hypothermic Circulatory Arrest with and Without Antegrade Selective Cerebral Perfusion: Evidence from Nontargeted Tissue Metabolomics in a Rabbit Model.

Background: Antegrade selective cerebral perfusion (ASCP) is regarded to perform cerebral protection during the thoracic aorta surgery as an adjunctive technique to deep hypothermic circulatory arrest (DHCA). However, brain metabolism profile after ASCP has not been systematically investigated by metabolomics technology.

Methods: To clarify the metabolomics profiling of ASCP, 12 New Zealand white rabbits were randomly assigned into 60 min DHCA with (DHCA+ASCP [DA] group, n = 6) and without ( DHCA [D] group, n = 6) ASCP according to the random number table.

A novel and feasible way to cultivate and purify endothelial progenitor cells from bone marrow of children with congenital heart diseases.

Background: Endothelial progenitor cells (EPCs) are used in vascular tissue engineering and clinic therapy. Some investigators get EPCs from the peripheral blood for clinic treatment, but the number of EPCs is seldom enough. We have developed the cultivation and purification of EPCs from the bone marrow of children with congenital heart disease, to provide enough seed cells for a small calibre vascular tissue engineering study.

Extracorporeal membrane oxygenation during double-lung transplantation: single center experience.

Background: For patients with end-stage lung diseases, lung transplantation is the final therapeutic option. Sequential double-lung transplantation is recognized as an established procedure to avoid cardiopulmonary bypass (CPB). But some of the sequential double-lung transplantations require CPB support during the surgical procedure for various reasons.

Passive graft perfusion in off-pump coronary artery bypass grafting.

Background: Myocardial protection during off-pump coronary artery bypass grafting (OPCABG) is a multifactorial problem in which maintaining stable systemic hemodynamics is very important. In this study passive graft perfusion (PGP) was applied to investigate the effect during and after OPCABG as evaluated by cardiac troponin I (CTnI) and hemodynamic indexes.

Methods: Thirty first-time patients underwent OPCABG under one surgeon.

[Comparative study of pulmonary function after conventional ultrafiltration or modified ultrafiltration during cardiac surgery of infants].

Objective: To compare the effects of conventional ultrafiltration and modified ultrafiltration in protecting patients' pulmonary function during cardiopulmonary bypass.

Methods: Thirty infants patients (less than 7 kg) were divided into two groups: conventional ultrafiltration group (CUF, n = 15) and modified ultrafiltration group (MUF, n = 15). The volume of ultrafiltration, transfusion, hematocrit (HCT) before and after ultrafiltration, patients' respiration function (respiration index, A-aDO2, airway pressure), the time of mechanical ventilation and ICU in the two groups were respectively monitored.