Publications by authors named "Bing-Xin Ma"
Article Synopsis
- - The study investigated how different durations of a cognitive-motor training program impact cognitive function in older adults with amnestic mild cognitive impairment (aMCI) in China, involving 72 participants from a nursing home.
- - Results showed significant improvements in global cognition, visuospatial ability, and executive function after both 12 and 24 weeks of training, although attention did not show improvements after 12 weeks.
- - The findings indicate that longer multi-domain cognitive-motor training can enhance cognitive functions, especially in attention and executive function for older adults with aMCI.
Background: Obesity poses a significant global health challenge, with profound implications for women's reproductive health. The relationship between ovarian reserve and body mass index (BMI) remains a subject of debate. While obesity is generally associated with poorer outcomes in assisted reproductive technology (ART), the evidence remains inconclusive.
View Article and Find Full Text PDFBackground: The best method for selecting embryos ploidy is preimplantation genetic testing for aneuploidies (PGT-A). However, it takes more labour, money, and experience. As such, more approachable, non- invasive techniques were still needed.
View Article and Find Full Text PDFDynamic-related protein 1 (DRP1) is a key protein of mitochondrial fission. In this study, we found that inhibition of activity of DRP1 led to increased levels of cleavage embryo genes in mouse embryonic stem cells (mESCs), which might reflect a transient totipotency status derived from pluripotency. This result indicates that DRP1 inhibition in mESCs leads to a tendency to obtain a new expression profile similar to that of the 2C-like state.
View Article and Find Full Text PDFNuclear factor (erythroid-derived 2)-like 2 (Nrf2) is an essential regulatory target of antioxidants, but the lack of Nrf2 active site information has hindered discovery of new Nrf2 agonists from food-derived compounds by large-scale virtual screening. Two deep-learning models were separately trained to screen for Nrf2-agonists and safety. The trained models screened potentially active chemicals from approximately 70,000 dietary compounds within 5 min.
View Article and Find Full Text PDFObjective: This study aimed to investigate the influence of different culture media on early embryonic cleavage kinetics using time-lapse analysis and to determine the possible relationships between energy substrates in culture media and the cleavage kinetics.
Methods: A total of 10 021 embryos from 1310 couples were cultured in time-lapse incubators. Embryos cultured in Vitrolife media were allocated to group I, and those in COOK media to group II.
Background: Elective single blastocyst transfer (eSBT) is considered to reduce the incidence of multiple pregnancy compared to double embryo transfer. Blastocyst selection is the key to achieving pregnancy. In the past, morphological assessment was the main criterion used to select blastocyst.
View Article and Find Full Text PDFArticle Synopsis
- A study examined 15,252 fresh transfer cycles to compare the time-lapse culture system (TLS) with the conventional culture system (CS) in assisted reproduction from 2016 to 2019.* -
- After matching the groups for fairness, the study found no differences in miscarriage rates, ectopic pregnancies, or live births, while TLS showed better clinical pregnancy and implantation rates.* -
- Overall, neonatal outcomes (like preterm deliveries, birth weight, and malformations) were similar between both systems, suggesting TLS is as safe as CS for embryo culture.*
The root of Pueraria lobata has been utilized as a food source for thousands of years in China. Puerarin is the major bioactive and the most abundant secondary metabolite obtained from the root of P. lobata.
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- Coptis chinensis inflorescence has been used as tea and shows potential for protecting the liver from damage caused by carbon tetrachloride (CCl4), though the exact mechanism was previously unclear.
- In this study, researchers identified key chemicals in C. chinensis extract (CE) and found that both CE and linarin improved cell viability and reduced liver enzyme levels and reactive oxygen species in liver cells.
- The protective effects are linked to the activation of specific signaling pathways involving MAPKs and Keap1, leading to the increased expression of detoxifying enzymes that help protect the liver, supporting C. chinensis inflorescence as a promising food supplement.
Article Synopsis
- Cyclophosphamide (CP) is a common chemotherapy drug that can cause liver damage due to its metabolite, acrolein.
- A study found that Cichorium glandulosum seed (CGS) can help reduce this liver toxicity in mice, primarily through its active compound, cynarin.
- Cynarin improves cell survival by restoring glutathione levels, reducing reactive oxygen species, and enhancing the protective Nrf2 pathway, which is key in cellular defense against damage.