Publications by authors named "Bing-Xia Su"
The predicted toxicity of mixtures of imidazolium and pyridinium ionic liquids (ILs) in the ratios of their EC50, EC10, and NOEC (no observed effect concentration) were compared to the observed toxicity of these mixtures on luciferase. The toxicities of EC50 ratio mixture can be effectively predicted by two-stage prediction (TSP) method, but were overestimated by the concentration addition (CA) model and underestimated by the independent action (IA) model. The toxicities of EC10 ratio mixtures can be basically predicted by TSP and CA, but were underestimated by IA.
View Article and Find Full Text PDFResults from three mathematical approaches to predict the toxicity of uniform design mixtures of four heavy metals (HMs) including Cd(II), Ni(II), Cu(II), and Zn(II) and six ionic liquids (ILs) were compared to the observed toxicity of these mixtures on Vibrio qinghaiensis sp.-Q67. Single toxicity analysis indicated that the ILs had greater toxicity than the HMs.
View Article and Find Full Text PDF[Microplate luminometry for toxicity bioassay of chemicals on luciferase].
Guang Pu Xue Yu Guang Pu Fen Xi
October 2013
Article Synopsis
- A new microplate luminometry method was developed to assess chemical toxicity using firefly luciferase in a multifunctional microplate reader.
- The study systematically tested various factors influencing luminescence, finding that optimal ATP concentration for maximum light output was 1.1 x 10(-4) mol x L(-1).
- The method effectively evaluated the toxic effects of several chemicals, showing high accuracy and fast results using dose-response curves with R2 values over 0.99 and precise EC50 measurements.