Publications by authors named "Bing-Wen Zhu"
Article Synopsis
- Neuropeptide Y (NPY) is a nerve system-produced peptide that plays a role in kidney health, showing protective effects in acute kidney injury (AKI) in both humans and animal models.
- In cases of cisplatin-induced AKI, NPY levels were found to be reduced, and mice lacking NPY experienced worse kidney inflammation and damage.
- The study suggests that NPY protects kidneys by inhibiting the inflammatory response of M1 macrophages through a specific signaling pathway, indicating its potential as a new treatment for kidney injuries.
Acute kidney injury (AKI) is a serious complication in critically ill patients. Accumulating evidences indicated that macrophages play an important pro-inflammatory role in AKI and isoliquiritigenin (ISL) can inhibit macrophagic inflammation, but its role in AKI and the underlying mechanism are unknown. The present study aims to investigate the renoprotective effect of ISL on AKI and the role of Formyl peptide receptors 2 (FPR2) in this process.
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