Unraveling the infrared detection properties of BiTe depending on thickness under the semiconductor and metal surface states.

BiTe recently emerges as a promising candidate material for the next generation of mid-wave to long-wave infrared photodetection owing to its exceptionally narrow bandgap (approximately 0.2 eV) and the favorable photoelectronic properties. In particular, its topological insulator structure is safeguarded by time-reversal symmetry, leading to electronic structures with distinct surface and bulk states as well as distinctive optoelectronic properties.

Electrosynthesis of Atomically Precise Au Nanoclusters.

Innovation in synthesis methodologies is crucial for advancing the discovery of new materials. This work reports the electrosynthesis of a [Au(4-BuPhC≡C)(Dppe)]Cl nanocluster (Au NC) protected by alkynyl and phosphine ligands. From simple precursor, HAuCl and ligands, the whole synthesis is driven by a constant potential in single electrolytic cell.

Genome-Wide Association Studies Reveal the Genetic Architecture of Ionomic Variation in Grains of Tartary Buckwheat.

Tartary buckwheat (Fagopyrum tataricum) is esteemed as a medicinal crop due to its high nutritional and health value. However, the genetic basis for the variations in Tartary buckwheat grain ionome remains inadequately understood. Through genome-wide association studies (GWAS) on grain ionome, 52 genetic loci are identified associated with 10 elements undergoing selection.

Controversy and multiple roles of the solitary nucleus receptor Nur77 in disease and physiology.

Neuron-derived clone 77 (Nur77), a member of the orphan nuclear receptor family, is expressed and activated rapidly in response to diverse physiological and pathological stimuli. It exerts complex biological functions, including roles in the nervous system, genome integrity, cell differentiation, homeostasis, oxidative stress, autophagy, aging, and infection. Recent studies suggest that Nur77 agonists alleviate symptoms of neurodegenerative diseases, highlighting its potential as a therapeutic target in such conditions.

Spermidine alleviates copper-induced oxidative stress, inflammation and cuproptosis in the liver.

Copper exposure poses potential detrimental effects on both public and ecosystem health. Spermidine, an antioxidant, has shown promise in reducing oxidative stress and inflammation within the liver. However, its specific role in mitigating copper-induced hepatic cuproptosis and disturbances in copper metabolism remains unexplored.

Efficacy of Linaclotide in Functional Dyspepsia and Constipation-Predominant Irritable Bowel Syndrome Overlap: A Randomized Trial.

Background And Aim: Linaclotide is effective in relieving constipation-predominant irritable bowel syndrome symptoms. However, few studies focus on the efficacy of linaclotide for overlapping symptoms of functional dyspepsia among irritable bowel syndrome patients. This study aimed to assess the efficacy of linaclotide compared with lactulose in patients with functional dyspepsia and constipation-predominant irritable bowel syndrome overlap.

Protective effects of Paeonia suffruticosa callus extract in skin through anti-inflammation and repair UVB-induced damage.

Objective: The study investigated effects of peony callus extracts (PCE) on the protective efficacy against Ultraviolet B (UVB)-induced photoageing, using in vitro and in vivo studies. The research focused on PCE's ability to protect against inflammatory factors, DNA damage and accumulation of senescent cells, along with the evaluation of the extract's potential anti-photoageing benefits to skin.

Methods: Human keratinocyte cell line (HaCaT cells), mast cells and fibroblasts were used to evaluate the role of PCE in anti-photoageing.

Effect of intermittent hemodialysis filtration mode on intradialytic hypotension and nutritional status in patients with end-stage renal disease.

Introduction: This study aimed to investigate the effect of intermittent hemodialysis filtration mode (IHDF) on intradialytic hypotension and nutritional status in patients with end-stage renal disease (ESRD).

Methods: Patients with ESRD who underwent hemodialysis and were treated at our hospital from December 2021 to December 2023 according to the inclusion and exclusion criteria were selected and randomly assigned into two groups: the experimental group (patients received intermittent hemodialysis filtration mode treatment, n = 50) and the control group (patients received conventional maintenance hemodialysis treatment, n = 49). Subsequently, the participant characteristics, the treatment effect, the occurrence of intradialytic hypotension, the safety assessment, blood pressure indicators, and the nutritional status were compared between the two groups.

Efficient Extraction, Chemical Characterization, and Bioactivity of Essential Oil From Pine Needles.

Introduction: Pine needles are a rich source of bioactive compounds, and there are few reports on the extraction and identification of active substances in various types of pine needles.

Objectives: The objective of this study is to enhance the efficiency and yield of pine needle essential oil extraction by employing an innovative ultrasonic-assisted salt-out hydrodistillation technology. It also aims to establish a correlation between gas chromatography-mass spectrometry (GC-MS) and electronic nose (E-nose) to distinguish essential oils from Cedrus deodara, Pinus thunbergii, Pinus massoniana, and Pinus koraiensis.

Risk Prediction Models for Stress Urinary Incontinence in Pregnant and Postpartum Women: A Systematic Review and Critical Appraisal.

Background: Many studies have developed or validated prediction models to estimate the risk of stress urinary incontinence (SUI) in pregnant and postpartum women, but the quality of the model development and model applicability remains unknown.

Objectives: To systematically review and critically evaluate currently available prediction models for SUI in pregnant and postpartum women.

Search Strategy: Cochrane Library, EBSCO, PubMed, Web of Science, EMBASE, Chinese CNKI, Wanfang and VIP databases were searched from inception until February 2024.

On-site genetic diagnosis for the invasive pest Hylurgus ligniperda (Fabricius) and its possible application.

Background: Forests in nearly all regions worldwide are affected by invasions of non-native bark beetles. Hylurgus ligniperda (Fabricius) is a globally invasive bark beetle that stealthily jeopardizes pine health and spreads worldwide insidiously. The worldwide occurrence of Hylurgus ligniperda challenges trade in pine logs or wooden materials.

Treat-And-Extend Versus Pro Re Nata Regimen of Intravitreal Conbercept Injection for Neovascular Age-Related Macular Degeneration: Results from COCOA, a Prospective, Open-Label, Multicenter, Randomized Phase IV Clinical Trial.

Purpose: To evaluate and contrast the effectiveness and safety of two conbercept treatment protocols-a three-dose treat-and-extend (3+T&E) regimen and a three-dose pro re nata (3+PRN) regimen-in Chinese patients diagnosed with neovascular age-related macular degeneration (nAMD).

Methods: Eligible patients, who had not undergone anti-VEGF intraocular injections within 3 months prior to enrollment, were randomly assigned to either the 3+T&E or 3+PRN regimen. The 3+T&E group received at least three monthly injections, with subsequent visit intervals extended based on disease activity assessment.

Tailoring OER/ORR activity in TMN catalysts through first-/second-shell nitrogen doping: a density functional theory investigation.

Proposing an effective modification strategy to optimize catalyst reaction potentials is crucial for enhancing catalytic performance. In this study, we employed a combined approach by adjusting nitrogen dopants in the first- and second-shell environments to tailor the OER/ORR reaction potentials of FeN, CoN, and NiN active centers. Using density functional theory simulations, we systematically compared the effects of first- and second-shell nitrogen dopants on the local atomic/electronic structures and catalytic activities.

Lithium Bond-Mediated Molecular Cascade Hydrogel for Injury-Free and Repositionable Adhesive Bioelectronic Interfaces.

Flexible bioelectronic interfaces with adhesive properties are essential for advancing modern medicine and human-machine interactions. However, achieving both stable adhesion and non-damaging detachment remains a significant challenge. In this study, a lithium bond-mediated molecular cascade hydrogel (LMCH) for bioelectronic interfaces is designed, which facilitates robust adhesion at the tissue level and permits atraumatic detachment for repositioning as required.

Loss of N-6 adenine-specific DNA methyltransferase 1 leads to meiotic prophase abnormalities and male sub-fertility in mice.

Mammalian sexual reproduction critically relies on the generation of haploid gametes following a specialized cell division process known as meiosis. Here, we demonstrate that N-6 Adenine-Specific DNA methyltransferase 1 (N6AMT1) plays a crucial role in the progression of meiosis during spermatogenesis, as follows. N6AMT1 was expressed in germ cells throughout the entire process of spermatogenesis, with a peak in mRNA levels in spermatocytes at the prophase I stage of meiosis.

March2 Alleviates Aortic Aneurysm/Dissection by Regulating PKM2 Polymerization.

Background: Aortic aneurysm/dissection (AAD) is a life-threatening disease lacking effective pharmacological treatment. Protein ubiquitination plays a pivotal role in cardiovascular diseases. However, the possible contribution of the E3 ubiquitin ligase March2 (membrane-associated RING finger protein 2) to the cause of AAD remains elusive.

Effects of tea polyphenols disinfectant on microbial communities and potential pathogenic bacteria in water.

The structural and abundance changes in water disinfected by tea polyphenols were investigated in high-abundance microbial communities (HAMC), medium-abundance microbial communities (MAMC), and low-abundance microbial communities (LAMC), also included the interactions within and between these communities. The antibacterial effect of tea polyphenols was observed at concentrations of 20-300 mg/L. If the tea polyphenols concentration is greater than or equal to 200 mg/L, it can continue to inhibit the growth of bacteria, and keep the total number of bacteria in 48 hours no more than100 CFU/ml, and this reflected the continuity of tea polyphenols disinfectant in the pipe network.

Intratumoral Injection of R848 and Poly(I:C) Synergistically Promoted Antitumour Immune Responses by Reprogramming Macrophage Polarization and Activating DCs in Lung Cancer.

Introduction: Immunotherapy has rapidly become a primary treatment option for many lung cancer patients because of its success in treating this prevalent and deadly disease. However, the success of immunotherapy relies on overcoming the immunosuppressive tumour microenvironment, making remodelling this environment a potential strategy for lung cancer therapy. Research suggests that Toll-like receptor (TLR) agonists can impede tumour growth by promoting the conversion of tumour-associated macrophages into an M1-like state or enhancing dendritic cell development.

Cascade-Responsive Nanoprodrug Disrupts Immune-Fibroblast Communications for Potentiated Cancer Mechanoimmunotherapy.

The abnormal tumor mechanical microenvironment due to specific cancer-associated fibroblasts (CAFs) subset and low tumor immunogenicity caused by inefficient conversion of active chemotherapeutic agents are two key obstacles that impede patients with desmoplastic tumors from achieving stable and complete immune responses. Herein, it is demonstrated that FAP-αCAFs-induced stromal stiffness accelerated tumor progression by precluding cytotoxic T lymphocytes. Subsequently, a cascade-responsive nanoprodrug capable of re-educating FAP-αCAFs and amplifying tumor immunogenicity for potentiated cancer mechanoimmunotherapy is ingeniously designed.

Flexible Patterned Fuel Cell Patches Stimulate Nerve and Myocardium Restoration.

The distribution of electrical potentials and current in exogenous electrostimulation has significant impacts on its effectiveness in promoting tissue repair. However, there is still a lack of a flexible, implantable power source capable of generating customizable patterned electric fields for in situ electrostimulation(electrical stimulation). Herein, this study reports a fuel cell patch (FCP) that can provide in situ electrostimulation and a hypoxic microenvironment to promote tissue repair synergistically.

Impact of hematopoietic cell transplantation and quizartinib in newly diagnosed patients with acute myeloid leukemia and FMS-like tyrosine kinase 3-internal tandem duplications in the QuANTUM-First trial.

QuANTUM-First (NCT02668653) was a randomized phase 3 trial in newly diagnosed FLT3-ITDQpositive acute myeloid leukemia (AML) patients treated with quizartinib or placebo plus standard induction and consolidation chemotherapy and/or allogeneic hematopoietic cell transplantation (allo-HCT), followed by single-agent maintenance therapy. We evaluated the impact of allo-HCT performed in first complete remission (CR1) or composite CR1 (CRc1) on overall survival (OS), considering treatment randomization. Post-hoc extended Cox regression multivariable analyses were conducted in patients who achieved CR/CRc by the end of induction, including allo-HCT in CR1/CRc1 as a time-dependent variable to identify prognostic and predictive factors for OS.

Controlled Modulation of Intrinsic Electron Response in C/CoT Nanoplates Toward Multispectral Excitation Devices.

Electromagnetic materials with adjustable dielectric and magnetic properties are constantly sought after in electronic and industrial fields. In this study, an innovative strategy that customizes anchored Co-based nanoparticles to optimize the electronic behaviors is proposed for the first time, enabling a controllable and high-efficiency evolution of the macroscopic electromagnetic response of Co-based (C/CoT) nanoplates across the X-ray, light in the solar band and gigahertz band. Specifically, in the gigahertz band, the C/Co and C/CoSe nanoplates with high-power loss capabilities can effectively attenuate and convert electromagnetic energy into heat energy, which not only prevents space electromagnetic radiation but also powers energy for various electromagnetic devices such as thermoelectric generators and microwave actuators.

Crystalline CoP@ Amorphous WP Coaxial Nanowire Arrays as Bifunctional Electrocatalyst for Water Splitting.

The crystalline CoP@ amorphous WP core-shell nanowire arrays are oriented grown on the Ni foam (CoP@WP/NF). The amorphous WP shell provides more active sites, and the interface charge coupling accelerates the kinetic of the catalytic reaction, making the CoP@WP/NF catalysts excellent activity. In acidic, only 13 and 97 mV overpotentials are needed to reach 10 mA cm and 100 mA cm, respectively, which are the lowest overpotentials among all reported Transition metal phosphide (TMP) catalysts, of course, much lower than that of the Pt/C catalyst (31 mV at 10 mA cm, 120 mV at 100 mA cm).

Underlying characteristic aroma of white tea from diverse geographical origins and its prediction.

Background: White tea, an agriculturally distinctive product, exhibits significant aroma variations across different regions. Nevertheless, the mechanisms driving these differences, and distinguishing methods suitable for specific origins, have been scarcely reported. In this study, we analyzed the aroma characteristics and volatile components of 100 white tea samples from ten regions, utilizing sensory evaluation, headspace solid-phase microextraction-gas chromatography-mass spectrometry and chemometrics, then established a discrimination model.

p16INK4a Deletion Alleviated Obesity-Associated Kidney Fibrosis by Regulating Metabolic Reprogramming and the Inflammasome Pathway.

Recent research has revealed a close association between obesity and various metabolic disorders, including renal metabolic diseases, but the mechanism is still unknown. This study explored the role of p16INK4a in obesity-related kidney fibrosis and evaluated its potential as a therapeutic target. Using wild-type (WT) mice and p16 KO mice, we fed both groups a high-fat diet (HFD) for 6 months.