Publications by authors named "Bing-Nan Yang"
Article Synopsis
- - Studies on young rodents indicate that anesthetic exposure, particularly to isoflurane, can lead to brain cell death and cognitive issues linked to the hippocampus, highlighting potential risks during critical developmental periods.
- - Research focused on identifying the specific molecular changes in the dentate gyrus of 7-day-old mice after exposure to isoflurane and found significant changes in 1,059 pairs of miRNAs and target genes.
- - The altered miRNAs and target genes were associated with vital processes like cell death, axon growth, and synapse function, providing new insights into how anesthetics can negatively impact brain development.
In temporal lobe epilepsy (TLE), abnormal axon guidance and synapse formation lead to sprouting of mossy fibers in the hippocampus, which is one of the most consistent pathological findings in patients and animal models with TLE. Glypican 4 (Gpc4) belongs to the heparan sulfate proteoglycan family, which play an important role in axon guidance and excitatory synapse formation. However, the role of Gpc4 in the development of mossy fibers sprouting (MFS) and its underlying mechanism remain unknown.
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