Publications by authors named "Bing-Chang Yang"
Article Synopsis
- The study focused on the population pharmacokinetics of colistin sulfate in critically ill adult patients receiving intravenous treatment for over 72 hours, measuring drug concentrations via advanced chromatography techniques.
- A two-compartment model was developed for colistin clearance, identifying creatinine clearance (CrCL) and alanine aminotransferase (ALT) as key factors influencing drug distribution and elimination.
- Monte Carlo simulations indicated that standard dosing regimens were often inadequate for patients with normal kidney function or infections from resistant pathogens, suggesting a need for adjustments based on individual renal function and microbiological susceptibility.
Naringin exhibited various pharmacological activities. However, its biological function and underlying mechanism in regulating macrophage polarization remain elusive. This study aimed to investigate the regulatory network between naringin and macrophage polarization in sepsis-induced intestinal injury.
View Article and Find Full Text PDFBackground: Severe acute pancreatitis (SAP) is a common acute abdominal disease with high morbidity and mortality. However, the mechanism underlying SAP is still unclear.
Methods: Cerulean and LPS (Cer-LPS) was used to establish a rat model and an model of SAP.
Acute pancreatitis (AP) is an inflammatory, complicated pancreatic disease, carrying significant morbidity and mortality. However, the molecular and cellular mechanisms involved in AP pathogenesis remain to be elucidated. Here, we explore the role of FOXF1 adjacent non-coding developmental regulatory RNA (FENDRR) in AP progression.
View Article and Find Full Text PDFContext: Sepsis is currently one of the leading causes of death in intensive care units (ICUs). Sesamin was previously reported to inhibit inflammation. However, no studies have revealed the impact of sesamin on sepsis.
View Article and Find Full Text PDFObjectives: MicroRNAs have been considered to be closely related with the development of severe acute pancreatitis (SAP), and microRNA-375 (miR-375) was believed to be a marker of SAP. We aim to investigate the role of miR-375 in regulating SP.
Methods: Cerulein and lipopolysaccharide were used to establish the models of SAP.
[Clone of hepatitis B virus X gene and its protein expression].
Zhong Nan Da Xue Xue Bao Yi Xue Ban
October 2005
Objective: To construct the hepatitis B virus (HBV) X gene recombinant and to induce the expression of X protein.
Methods: HBV DNA was extracted from the serum of patient with hepatitis B. The X gene was amplified by PCR using the primers with EcoRI and HindIII digestion sites, and then cloned into pronucleus expression vector pMAL-C2X, which was detected by EcoRI and HindIII digestion and sequence.