Publications by authors named "Bing Yuan Wang"
Objectives: Non-alcoholic fatty liver disease (NAFLD) is becoming the leading cause of chronic liver disease worldwide. However, treatment of NAFLD is potentially influenced by psychological conditions. Using the simplified version of the University of Rhode Island Change Assessment (URICA-SV) scale, this study aimed to evaluate the stage of psychological change as a prerequisite to refining implementation strategies for psychological change.
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- The Chronic Liver Disease Questionnaire for Nonalcoholic Fatty Liver Disease (CLDQ-NAFLD) was translated into Chinese to evaluate its effectiveness in measuring the health-related quality of life (HRQL) among Chinese NAFLD patients.
- A multicenter study involving 5181 participants confirmed the questionnaire's reliability and validity through various statistical methods, such as Cronbach's alpha and factor analysis.
- The findings indicate that the Chinese version of CLDQ-NAFLD is a trustworthy tool for assessing HRQL in this patient population.
Article Synopsis
- - The study investigates how gut microbiota composition affects iron absorption in wild-type (WT) versus double-gene-knockout (DKO) piglets, using various sequencing and analytical techniques to examine the microbiota across the digestive tract.
- - Findings indicate no significant differences in overall microbial communities between WT and DKO piglets, but DKO piglets showed increased levels of certain bacteria and higher iron levels in key tissues, suggesting a potential role for specific microbes in iron absorption.
- - The research highlights the interactions between colonic microbiota and host metabolism, with potential implications for addressing iron deficiency in piglets, a common concern that can lead to anemia.
Several studies have suggested a role for gut mucosa-associated microbiota in the development of obesity, but the mechanisms involved are poorly defined. Here, the impact of the gut mucosa-associated microbiota on obesity and related metabolic disorders was evaluated in a metabolic syndrome (MetS) porcine model. Body composition was determined among male Wuzhishan minipigs consuming a high-energy diet (HED) and compared to that of those consuming a normal diet (ND), and gut segments (duodenum, jejunum, ileum, cecum, colon, and rectum) were sampled for paired analysis of mucosa-associated microbiota and transcriptome signatures with 16S rRNA gene and RNA sequencing, respectively.
View Article and Find Full Text PDFThe diagnosis of metabolic-associated fatty liver disease is based on the detection of liver steatosis together with the presence of metabolic dysfunction. According to this new definition, the diagnosis of metabolic-associated fatty liver disease is independent of the amount of alcohol consumed. Actually, alcohol and its metabolites have various effects on metabolic-associated abnormalities during the process of alcohol metabolism.
View Article and Find Full Text PDFBackground: Health Related Quality of Life (HRQL) is a multi-dimensional construct that can comprehensively evaluate the patient's health status, including physical, emotional, mental and social well-being. In this study, we aimed to evaluate the impact of non-alcoholic fatty liver disease (NAFLD) on HRQL in a Chinese population.
Methods: In this national multicenter cross-sectional survey, patients with NAFLD were enrolled.
Article Synopsis
- Stem cell technology is crucial in life sciences, allowing the acquisition of stem cells through three main methods: isolating embryonic stem cells, adult stem cells, and reprogramming differentiated cells into induced pluripotent stem cells.
- In agriculture, stem cell technology enhances somatic cell cloning and genetic modifications in livestock, leading to a more efficient creation of genetically modified animals.
- The integration of stem cell technology with gene editing and other techniques holds potential for advancements in disease prevention, treatment in agricultural animals, and overall genetic improvement.
Article Synopsis
- * HTGW was found in 23.71% of participants, while 11.79% had T2DM, with females showing higher rates of both conditions compared to males.
- * After adjusting for various health factors, having HTGW significantly increased the risk of developing T2DM, highlighting a concerning public health issue in this rural population.
Article Synopsis
- A systematic review and meta-analysis examined the link between chocolate consumption and cardiovascular disease (CVD) risk, due to mixed findings in previous studies.
- Fourteen publications and 23 studies encompassing over 405,000 participants showed a slight decrease in CVD risk with increased chocolate intake, particularly at around 45g per week.
- Consuming less than 100g of chocolate per week may lower CVD risk, but larger amounts could have negative health effects due to high sugar content.
Article Synopsis
- This study looked at how specific gene variants (TCF7L2 and GCG) relate to glucose metabolism and the risk of developing type 2 diabetes in a rural Chinese adult population.
- Out of 7,751 participants who were not diabetic at the start, 227 developed type 2 diabetes during an average follow-up of 6 years.
- The research found that certain gene variants (like TCF7L2 rs7903146) were linked to a significantly higher risk of diabetes, increased insulin levels, and obesity measures in those who became diabetic.
Objective: This meta-analysis was performed to summarize the association of the ADIPOQ rs2241766 and rs266729 polymorphisms with metabolic syndrome (MS) in the Chinese population.
Methods: We searched for articles in MEDLINE via PubMed, EMBASE, HuGE Navigator, CNKI, and Wanfang databases and calculated odds ratios (ORs) with 95% confidence intervals (CIs) to determine the strength of associations in fixed- or random-effects models.
Results: We included 21 articles in the meta-analysis: 17 reports of ADIPOQ rs2241766 with 3628 cases and 3000 controls and 8 of rs266729 with 2021 cases and 2226 controls.
Although a series of studies have shown that VSL#3 (L plantarum, L Bulgaricus, L casei and L. acidophilus, B breve, B longum and B infantis and S salivarius subspecies thermophilus) can exert therapeutic effects on colitis, whether heat-killed VSL#3 also can exert similar effects has never been tested. The aim of the study was to investigate whether heat-killed VSL#3 exert therapeutic effects in chronic experimental colitis by inhibiting STAT3 pathway.
View Article and Find Full Text PDFObjective: To investigate the association between low-density lipoprotein receptor-related protein 5 (LRP5) variants (rs12363572 and rs4930588) and type 2 diabetes mellitus (T2DM) in Han Chinese.
Methods: A total of 1842 T2DM cases (507 newly diagnosed cases and 1335 previously diagnosed cases) and 7777 controls were included in this case-control study. PCR-RFLP was conducted to detect the genotype of the two single nucleotide polymorphisms (SNPs).
Intestinal mucosal barrier dysfunction is closely related to liver diseases, which implies impaired gut-liver axis may play a role in the pathogenesis of NAFLD. In our study, rats were divided into three groups: normal chow diet (NCD) group, high-fat diet (HFD) group and TNBS-induced colitis with high-fat diet (C-HFD) group. Liver tissues were obtained for histological observation and TNF-α, IL-6 mRNA determination and blood samples were collected for liver enzymes and LPS analysis.
View Article and Find Full Text PDFGenetic polymorphisms in upstream transcription factor 1 (USF1) were investigated for their links to increased risk of nonalcoholic fatty liver disease (NAFLD) in Chinese population. Between January 2013 and April 2014, 174 patients with NAFLD in the First Affiliated Hospital of China Medical University were selected for this study. A group of 100 healthy subjects were identified as the control group.
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- This study explored how ethanol affects the expression of caveolin-1 (CAV-1) in HepG2 liver cancer cells using an in vitro model.
- Cell viability tests showed that ethanol concentrations below 1.0% did not affect cell health, but higher concentrations caused some shedding of the cells.
- The results indicated that ethanol increased the expression of CAV-1, as seen from significant differences in both protein and mRNA levels compared to the control group over various time periods.
Background: Adiponectin (AdipoQ) is an adipose-derived plasma protein that plays an important role in hepatic lipoprotein-lipid metabolism. Emerging evidence have shown that two common polymorphisms (T45 G and G276 T) in the AdipoQ gene may contribute to increasing susceptibility to nonalcoholic fatty liver disease (NAFLD); however individually published studies show inconclusive results. This meta-analysis aimed to derive a more precise estimation of the association of AdipoQ T45 G (rs2241766 T>G) and G276 T (rs1501299 G>T) polymorphisms with NAFLD risk.
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- * The analysis included 28 studies with a total of 3,294 patients, confirming that higher levels of DcR3 were associated with various cancer features such as TNM stages, differentiation grades, lymph node metastasis, degree of infiltration, and metastasis.
- * The findings suggest that DcR3 might be significant in understanding the progression and characteristics of gastrointestinal cancer.
Epidemiologic studies on the relationship between tea consumption and pancreatic cancer are inconsistent. Therefore, we conducted a systematic search of databases and performed a meta-analysis to analyze the association between tea consumption and risk of pancreatic cancer. We searched Medline, EMBASE, ISI Web of Science, and the Cochrane library for studies of tea consumption and pancreatic cancer published up to December 2012.
View Article and Find Full Text PDFRelationship of SREBP-2 rs2228314 G>C polymorphism with nonalcoholic fatty liver disease in a Han Chinese population.
Genet Test Mol Biomarkers
September 2014
Objective: This study aims at investigating the relationship of SREBP-2 rs2228314 G>C polymorphism with the risk of nonalcoholic fatty liver disease (NAFLD) in a Han Chinese population.
Method: This case-control study was conducted at the First Affiliated Hospital of China Medical University. Three-hundred subjects who met the diagnostic criteria of NAFLD and had typical clinical and ultrasonographic findings were placed in the case group.
This meta-analysis was performed to evaluate the relationships between genetic polymorphisms in the IL-18 gene and ulcerative colitis (UC) risk. The PubMed, CISCOM, CINAHL, Web of Science, Google Scholar, EBSCO, Cochrane Library, and CBM databases were searched for relevant articles published before November 1st, 2013 without any language restrictions. Meta-analysis was conducted using the STATA 12.
View Article and Find Full Text PDF[Recent progress in research of biomarkers of acute kidney injury in liver cirrhosis].
Zhonghua Gan Zang Bing Za Zhi
October 2013
MMP-2 and DcR3 expression in esophageal cancer tissue and correlation with patient survival.
Int J Clin Exp Med
September 2013
Objective: This study aims to explore the expression of decoy receptor 3 (DcR3) and the matrix metalloproteinase-2 (MMP-2) in esophageal carcinoma and their relationship with patient survival.
Methods: The EnVision(TM) immunohistochemistry method was used to examine DcR3 and MMP-2 expression in 150 surgical biopsies of esophageal carcinoma. Expression level was compared with clinical indices and with patient survival.
[Hepatic epithelioid hemangioendothelioma: a case report].
Zhonghua Gan Zang Bing Za Zhi
December 2012
[Attention to the progress of the genetic risk factors for non-alcoholic fatty liver disease (NAFLD].
Zhonghua Gan Zang Bing Za Zhi
October 2012