Intracorporeal versus extracorporeal neobladder in robot-assisted radical cystectomy: perioperative, oncological, and functional outcomes from a single-institutional experience.

Purpose: To compare the perioperative, functional, and oncological outcomes of the intracorporeal neobladder (ICNB) and extracorporeal neobladder (ECNB) technique following robot-assisted radical cystectomy (RARC).

Methods: We reviewed our single-institutional, prospectively collected database for consecutive patients who underwent RARC with an ileum neobladder from July 2016 to February 2023. Patients were divided into 2 groups according to the approach of reconstruction (ICNB or ECNB).

Chinese Position Paper on Biologic Therapy for Chronic Rhinosinusitis With Nasal Polyps.

Emerging biologics that selectively target key cytokines present a promising therapeutic alternative for patients suffering from severe, uncontrollable chronic rhinosinusitis with nasal polyps (CRSwNP). Despite the limited availability of registered biologics for CRSwNP treatment in China, the country is experiencing rapid development in this field. It is imperative to standardize the application of biologic agents in CRSwNP management in preparation for their future integration into the CRSwNP care pathway.

CD146 regulates the stemness and chemoresistance of hepatocellular carcinoma via JAG2-NOTCH signaling.

CD146 plays a key role in cancer progression and metastasis. Cancer stem cells (CSCs) are responsible for tumor initiation, drug resistance, metastasis, and recurrence. In this study, we explored the role of CD146 in the regulation of liver CSCs.

Misdiagnosis of Herlyn-Werner-Wunderlich syndrome combined with pelvic mesothelial cyst: a case report.

Herlyn-Werner-Wunderlich syndrome (HWWS) combined with pelvic mesothelial cyst is a rare condition that can be easily misdiagnosed. Our center presents a case study of this disease to provide clinicians with valuable insights for accurate diagnosis and treatment. A 12-year-old girl initially received a misdiagnosis of left lower abdominal ectopic kidney hydronephrosis based on B-ultrasound and renography due to intermittent abdominal pain.

G-Quadruplex Structures Formed by Human Telomere and GGGGCC Repeats.

G-quadruplexes (G4s) are unique nucleic acid structures composed of guanine-rich (G-rich) sequences that can form diverse topologies based on the arrangement of their four strands. G4s have attracted attention for their potential roles in various biological processes and human diseases. In this review, we focus on the G4 structures formed by human telomeric sequences, (GGGTTA), and the hexanucleotide repeat expansion, (GGGGCC), in the first intron region of the chromosome 9 open reading frame 72 () gene, highlighting their structural diversity and biological significance.

Application of patient derived xenograft model in personalized drug screening for chondrosarcoma of head and neck: A preclinical study.

Objectives: The effect of radiotherapy and chemotherapy on head and neck chondrosarcoma (HNCS) has not been unanimously determined because of the rarity of HNCS. Patient-Derived Xenograft (PDX) model is considered to be a good preclinical model for new drug development and personalized drug screening. We performed this study to investigate the preclinical application and value of PDX model in drug screening for HNCS.

New insights into the endotypes of chronic rhinosinusitis in the biologic era.

Chronic rhinosinusitis (CRS) exhibits significant heterogeneity and has been generally classified as type 1 (T1), T2, and T3 endotypes according to the histopathologic and inflammatory features of the nasal mucosa. T2 inflammation has been regarded as the predominant endotype of CRS linked to disease severity and refractory conditions. The development of biological agents that specifically target key molecules involved in T2 inflammation offers a highly effective and promising therapeutic approach for CRS.

, a novel rearrangement in lung squamous cell carcinoma and its clinical responses to ALK inhibitors.

Background: Lung cancer is the leading cause of cancer-related death worldwide, of which anaplastic lymphoma kinase fusion positive ( ) non-small cell lung cancer (NSCLC) accounts for 3-7. Here, we identified a new fusion gene (P1, A19) from a patient with advanced lung squamous cell carcinoma (LUSC) by next-generation sequencing (NGS). We aimed to evaluate its oncogenic potential by performing functional studies and tumorigenicity of this fusion protein.

Efficacy, physicochemical and processing properties of oat peptides prepared via ultrasonication-assisted organic acid hydrolysis.

Currently, the low efficiency and pollution issues associated with biological and chemical methods for the preparation of functional peptides continue to pose challenges, restricting the large-scale production and utilization of functional peptides. This study has found that the ultrasound-assisted organic acid-surfactant system is an efficient and green method for the preparation of functional peptides. The probe ultrasonication-assisted tartaric acid system successfully degraded oat globulins into peptides with a degree of hydrolysis (DH) of 22.

Application of Surface-Enhanced Raman Spectroscopy in Head and Neck Cancer Diagnosis.

Surface-enhanced Raman spectroscopy (SERS) has emerged as a crucial analytical tool in the field of oncology, particularly presenting significant challenges for the diagnosis and treatment of head and neck cancer. This Review provides an overview of the current status and prospects of SERS applications, highlighting their profound impact on molecular biology-level diagnosis, tissue-level identification, HNC therapeutic monitoring, and integration with emerging technologies. The application of SERS for single-molecule assays such as epidermal growth factor receptors and PD-1/PD-L1, gene expression analysis, and tumor microenvironment characterization is also explored.

σ-π Hyperconjugation as a Design Strategy for High-Performance Fluorescent Covalent Organic Frameworks.

Realizing efficient solid-state fluorescence in covalent organic frameworks (COFs) represents a persistent and fundamental challenge in materials science, hindering their application in next-generation optoelectronics. Herein, a transformative strategy leveraging σ-π hyperconjugation is introduced to enhance the fluorescence properties of COFs. The incorporation of a methyl group into a pyrene-based COF monomer yields an unprecedented fluorescence quantum yield increase of more than 100-fold, accompanied by significantly enhanced optoelectronic performance.

Exploring the structure and photodissociation mechanism of the electronic states of monochlorogermylene including the spin-orbit-coupling.

The electronic states of monochlorogermene (HGeCl) are computed by using the explicitly correlated internally contracted multireference configuration interaction (icMRCI-F12) method with Davidson correction. A total of 23 spin-free states with energy up to 9.4 eV as well as 55 spin-orbit coupled states generated by these spin-free states after considering the spin-orbit coupling (SOC) effect are investigated.

The prognostic value of circulating tumor DNA in malignant melanoma patients treated with immune checkpoint inhibitors: a systematic review and meta-analysis.

Background: Circulating tumor DNA (ctDNA) is an emerging biomarker in malignant melanoma(MM), and high levels of ctDNA may reflect a higher tumor load. However, its prognostic value for MM receiving immune checkpoint inhibitors(ICI) remains controversial. This meta-analysis aimed to elucidate the prognostic significance of ctDNA in this patient population.

GenAI synthesis of histopathological images from Raman imaging for intraoperative tongue squamous cell carcinoma assessment.

The presence of a positive deep surgical margin in tongue squamous cell carcinoma (TSCC) significantly elevates the risk of local recurrence. Therefore, a prompt and precise intraoperative assessment of margin status is imperative to ensure thorough tumor resection. In this study, we integrate Raman imaging technology with an artificial intelligence (AI) generative model, proposing an innovative approach for intraoperative margin status diagnosis.

Biological therapy in chronic rhinosinusitis with nasal polyps.

Introduction: Chronic rhinosinusitis with nasal polyps (CRSwNP) is a heterogeneous disease. High proportions of patients with CRSwNP characterized by type 2 inflammation fail to gain adequate control with conventional treatment. The application of biologics in clinics and assessments of novel biologics in clinical trials are blooming in expectations to fulfill the unmet medical needs of patients with CRSwNP with type 2 inflammation.

NupR Is Involved in the Control of PlcR: A Pleiotropic Regulator of Extracellular Virulence Factors.

NupR is a nucleoside permease regulator belonging to the GntR family, mainly regulating nucleoside transport in . A conserved binding site for NupR was found in the promoter region of . This study aimed to investigate the regulation of the virulence regulator PlcR by NupR and its impact on Bt virulence.

Unveiling whole body vibration squat intensity insight from oxygen consumption and heart rate response.

This study explored the effects of training weight and amplitude in whole-body vibration (WBV) on exercise intensity, indicated by oxygen consumption (VO) and heart rate. In LOAD-study: ten participants performed squats under non-WBV and WBV (30 Hz 2 mm) conditions at 0%, 40%, and 80% bodyweight (BW). In AMPLITUDE-study: eight participants performed squats under non-WBV, low-amplitude WBV (30 Hz 2 mm), and high-amplitude WBV (30 Hz 4 mm) conditions with 0% and 40%BW.

Assessment of Surgical Margin of Tongue Squamous Cell Carcinoma via Raman Mapping.

Objectives: This study introduces a novel classification approach that combines convolutional neural network (CNN) and Raman mapping to differentiate between tongue squamous cell carcinoma (TSCC) and non-tumorous tissue, as well as to identify different histological grades of TSCC.

Materials And Methods: In this study, 240 Raman mappings data from 30 tissue samples were collected from 15 patients who had undergone surgical resection for TSCC. A total of 18,000 sub-mappings extracted from Raman mappings were then used to train and test a CNN model, which extracted feature representations that were subsequently processed through a fully connected network to perform classification tasks based on the Raman mapping data.

Bionic Luminescent Sensors Based on Covalent Organic Frameworks: Auditory, Gustatory, and Olfactory Information Monitoring for Multimode Perception.

The synthesis of covalent organic frameworks (COFs) with excellent luminescent properties and their effective application in the field of bionic sensing remain a formidable challenge. Herein, a series of COFs with different numbers of hydroxyl groups are successfully synthesized, and the number of hydroxyl groups on the benzene-1,3,5-tricarbaldehyde (BTA) linker influences the properties of the final COFs. The COF (HHBTA-OH) prepared with hydrazine hydrate (HH) and BTA containing one hydroxyl group as the ligands exhibits the best fluorescent performance.

Absorption spectra of PS in the ultraviolet and infrared region.

The line list is essential for accurately modeling various astrophysical phenomena, such as stellar photospheres and atmospheres of extrasolar planets. This paper introduces a new line database for the PS molecule spanning from the ultraviolet to the infrared regions, covering wavenumbers up to 45000 cm and containing over ten million transitions between 150,458 states with total angular momentum J < 160. Accurate line intensities for rotational, vibrational and electronic transitions are generated by using the general purpose variational code DUO.

Electrochemical α-C(sp)-H/N-H Cross-Coupling of Isochromans and Azoles.

Isochroman and azole moieties are both present in a wide variety of biologically active molecules. Their efficient combination under mild reaction conditions is beneficial for obtaining small-molecule drug candidates. In this paper, we describe electrochemical α-C(sp)-H/N-H cross-coupling reactions between isochromans and azoles, yielding products in moderate to excellent yields.

Structure of the Se Isomers─An Ab Initio Study.

This study investigates the equilibrium geometries of four different Se isomers using the coupled cluster single and double perturbative (CCSD(T)) method, extrapolating to the complete basis sets. The ground-state geometry of the Se isomer with the C structure (2.8715 Å, 2.

Structural insights into hybridoma-derived neutralizing monoclonal antibodies against Omicron BA.5 and XBB.1.16 variants of SARS-CoV-2.

Unlabelled: The emergence of novel variants of severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2) continues to pose an ongoing challenge for global public health services, highlighting the urgent need for effective therapeutic interventions. Neutralizing monoclonal antibodies (mAbs) are a major therapeutic strategy for the treatment of COVID-19 and other viral diseases. In this study, we employed hybridoma technology to generate mAbs that target the BA.

Correction: Yan et al. Embryonic Lethal Phenotyping to Identify Candidate Genes Related with Birth Defects. 2024, , 8788.

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