Publications by authors named "Bing Xiong Fang"
Article Synopsis
- PMT1 is a special protein that helps cells handle stress in their endoplasmic reticulum (ER), which is important for keeping cells healthy.
- Scientists found that when they removed PMT1 from yeast cells, those cells lived longer compared to normal yeast cells.
- They also discovered that this longer life depended on other proteins called IRE1 and HAC1, which are involved in the stress response.
Yeast Cia2p is a component of the cytosolic Fe/S protein assembly (CIA) machinery. Initial studies of the CIA machinery were performed in yeast, but the precise role of Cia2p in this eukaryote is still unknown. We report that CIA2 deficiency results in impaired oxidative stress response, as evidenced by increased sensitivity to the oxidant cumene hydroperoxide (CHP), impaired activities of superoxide dismutases and aconitase and decreased replicative lifespan in the mutants.
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- Nar1p is an essential protein in yeast that is similar to bacterial hydrogenases and is crucial for the maturation of certain iron-sulfur proteins.
- Nar1p helps regulate oxygen sensitivity in yeast and C. elegans and its deficiency leads to shorter lifespans and increased sensitivity to oxidative stress from paraquat.
- Enhancing mitochondrial superoxide dismutase levels can rescue the negative effects of Nar1 deficiency, indicating that Nar1p plays a protective role against oxidative stress and contributes to lifespan extension.