Chiral europium halides with high-performance magnetic field tunable red circularly polarized luminescence at room temperature.

Chiral organic-inorganic hybrid metal halides as promising circularly polarized luminescence (CPL) emitter candidates hold great potential for high-definition displays and future spin-optoelectronics. The recent challenge lies primarily in developing high-performance red CPL emitters. Here, coupling the f-f transition characteristics of trivalent europium ions (Eu) with chirality, we construct the chiral Eu-based halides, (R/S-3BrMBA)EuCl, which exhibit strong and predictable red emission with large photoluminescence quantum yield (59.

Enhancing the Thermoelectric Performance of n-Type PbTe via Mn Doping.

Significant strides have been made in enhancing the thermoelectric properties of p-type PbTe alloys, whereas the thermoelectric performance of n-type alloys lags behind that of p-type alloys, primarily owing to the difficulty of improving their Seebeck coefficient via band convergence. In this work, Mn was introduced into the n-type PbSbTe alloy, and Mn doping increases the absolute value of the Seebeck coefficient significantly by increasing the effective mass and reducing carrier concentration, resulting in a higher power factor of 20.8 μW/Kcm being achieved for 0.

Does living alone exacerbate depression in older adults?

Introduction: Living alone, which has become increasingly common in China, weakens the emotional connections between parents and children-fundamental family functions in Confucianism. This trend has raised concerns regarding depression among older adults living alone. Numerous researchers have evaluated the influence of living alone on depression among older adults in different cultures.

Controllable Interfacial Growth of 2D Covalent Organic Framework Films for Organic Electronic Applications.

Two-dimensional covalent organic frameworks (2D COFs) are crystalline porous materials with predesignable topologies, periodic structures, and tunable functionalities constructed from molecular building blocks through covalent bonds. Their modular design allows for the integration of various functionalities, making 2D COFs highly suitable for optoelectronic applications. 2D COF films have emerged to integrate 2D COFs into optoelectronic devices, avoiding the low dispersibility and poor processability of powder COF materials.

A novel biomimetic strategy for mimicking amelogenesis to repair enamel.

According to the principle of minimal invasiveness in modern dentistry, biomimetic remineralization therapy constitutes a significant strategy for the prevention and treatment of early enamel caries. Based on the three "key events" of amelogenesis in vivo, silk fibroin (SF) combined with carboxymethyl chitosan (CMC) successfully formed an SF/CMC composite, and amorphous calcium phosphate (ACP) was then used to form an SF/CMC-ACP nanocomposite with remineralization properties. In our study, SF was used as a template protein for biomimetic amelogenin, ACP was stabilized with CMC and the remineralization was guided using NaClO to simulate the action of proteolytic enzymes.

Against the Wallach's Rule Through Rational Design of Metal-Free Chiral Perovskites Toward Efficient Red Circularly Polarized Phosphorescence.

The potential applications of circularly polarized phosphorescent materials in chiroptical devices have attracted considerable interest. Nevertheless, the design of efficient near-infrared/red circularly polarized phosphorescent pure organic materials remains a significant challenge, largely due to the limitations imposed by the energy-gap law and Wallach's rule. In this study, the chiral metal-free perovskite strategy is employed to overcome these restrictions.

Impacts of COVID-19 lockdown on PM-bound polycyclic aromatic hydrocarbons in Hohhot, Northern China: characteristics, sources, and source-specific health risks.

Quantifying the impacts of reduction strategies on PM-bound polycyclic aromatic hydrocarbons (PAHs) is essential for reducing the health risks of PM. The COVID-19 lockdown provided an opportunity to reveal the quantitative relationship between lockdown measures and the health risks of PAHs. In this study, the characteristics, sources, and health risks of PAHs were investigated during the COVID-19 lockdown in Hohhot.

Assessment of prognosis and responsiveness to immunotherapy in colorectal cancer patients based on the level of immune cell infiltration.

Objective: To build a new prognostic risk assessment model based on immune cell co-expression networks for predicting overall survival and evaluating the efficacy of immunotherapy for colon cancer patients.

Methods: The Cancer Genome Atlas (TCGA) database was used to obtain mRNA expression profiling data, clinical information, and somatic mutation data from colorectal cancer patients. The degree of tumor immune cell infiltration of the samples was analyzed using the CIBERSORT algorithm.

[Spatial and Temporal Characteristics and Controlling Factors of Water Quality of the Dahei River in the Yellow River Basin].

As an important ecological security barrier and an economic core belt for population activities, the Yellow River Basin plays an important role in China's social development and ecological security. To investigate the spatial and temporal changes in the water environmental quality of typical tributaries in the basin and the factors affecting them, this study was based on 12 aspects of water environmental data and month-by-month rainfall and runoff data from 21 monitoring stations in the Dahei River Basin from 2013 to 2022. The entropy-weighted water quality index （EWQI）, stepwise multiple linear regression, hierarchical cluster analysis, and Pearson correlation analysis were used to comprehensively assess the changes in the water quality of the basin and to investigate the factors controlling the water quality.

Recent Progress of Chemical Reactions Induced by Contact Electrification.

Contact electrification (CE) spans from atomic to macroscopic scales, facilitating charge transfer between materials upon contact. This interfacial charge exchange, occurring in solid-solid (S-S) or solid-liquid (S-L) systems, initiates radical generation and chemical reactions, collectively termed contact-electro-chemistry (CE-Chemistry). As an emerging platform for green chemistry, CE-Chemistry facilitates redox, luminescent, synthetic, and catalytic reactions without the need for external power sources as in traditional electrochemistry with noble metal catalysts, significantly reducing energy consumption and environmental impact.

Modified Cuff Leak Test for Predicting the Risk of Reintubation in Patients With Invasive Mechanical Ventilation: A Multicenter, Single-Blind, Randomized Controlled Trial.

Background: The cuff leak test (CLT) is an important tool to assess the risk of upper airway obstruction after extubation.

Research Question: Does a modified CLT approach have superior ability in predicting reintubation compared with the traditional method?

Study Design And Methods: This was a prospective, multicenter, randomized control trial. The primary end point was the incidence of the need for reintubation within 48 hours of extubation.

Loss of DDX24 inhibits lung cancer progression by stimulating IKBKG splicing-mediated autophagy.

Lung cancer remains a major global health burden with limited therapeutic options. Alternative splicing, a critical post-transcriptional process, contributes to lung cancer progression through autophagy, although the underlying mechanisms remain largely unexplored. This study aims to elucidate the role of DDX24 as a splicing factor that contributes to lung cancer progression via autophagy.

Pre-immunotherapy alters stereotactic ablative radiotherapy-induced systemic T cell responses in early-stage NSCLC.

Background: Stereotactic ablative radiotherapy (SABR) is thought to activate T cell responses in patients with cancer, leading to its combination with immunotherapy and chemotherapy for treatment of non-small-cell lung cancer (NSCLC). Here, we aimed to provide a high-resolution transcriptomic profiling of the systemic T cell response following SABR, with or without preceding immunotherapy/chemotherapy.

Methods: We conducted single-cell RNA and T cell receptor (TCR) sequencing of T cells from peripheral blood of seven patients with early-stage NSCLC taken pre- and post-SABR without or with prior immunotherapy and chemotherapy (icSABR).

Enabling high-performance multivalent metal-ion batteries: current advances and future prospects.

The battery market is primarily dominated by lithium technology, which faces severe challenges because of the low abundance and high cost of lithium metal. In this regard, multivalent metal-ion batteries (MVIBs) enabled by multivalent metal ions ( Zn, Mg, Ca, Al, ) have received great attention as an alternative to traditional lithium-ion batteries (Li-ion batteries) due to the high abundance and low cost of multivalent metals, high safety and higher volumetric capacities. However, the successful application of these battery chemistries requires careful control over electrode and electrolyte chemistries due to the higher charge density and slower kinetics of multivalent metal ions, structural instability of the electrode materials, and interfacial resistance, This review comprehensively explores the recent advancements in electrode and electrolyte materials as well as separators for MVIBs, highlighting the potential of MVIBs to outperform Li-ion batteries regarding cost, energy density and safety.

Enantioselective reductive cross-couplings to forge C(sp)-C(sp) bonds by merging electrochemistry with nickel catalysis.

Motivated by the inherent benefits of synergistically combining electrochemical methodologies with nickel catalysis, we present here a Ni-catalyzed enantioselective electroreductive cross-coupling of benzyl chlorides with aryl halides, yielding chiral 1,1-diaryl compounds with good to excellent enantioselectivity. This catalytic reaction can not only be applied to aryl chlorides/bromides, which are challenging to access by other means, but also to benzyl chlorides containing silicon groups. Additionally, the absence of a sacrificial anode lays a foundation for scalability.

The Impact of Air Pollution on Acute Angle-Closure Glaucoma in Hefei, China, 2017-2022: A Time-Series Study.

Objective: The study investigated the effects of air pollutants on the incidence of acute angle-closure glaucoma (AACG) in Hefei, China.

Methods: A combination of generalized additive models and distributed lag nonlinear models was used to explore the relationship between air pollutants and the incidence of AACG.

Results: Exposure-response curves showed that exposure to PM 2.

Remarkable increase in electrochemiluminescence of isomeric bipyridine-based covalent organic frameworks via regulating the direction of imine linkage for sensing application.

Covalent organic frameworks (COFs) with highly ordered structures and predictable optoelectronic properties provide an ideal platform to investigate the electrochemiluminescence (ECL) performance based on organic materials by atomically varying the molecular construction. Herein, the effect of imine-bond orientation on the ECL performance of COFs is investigated. We report two COFs (NC-COF and CN-COF) with different orientations of imine bonds using pyrene donor units (D) and bipyridine acceptor motifs (A) monomers.

Relationship Between Early-Life Factors and Self-Reported Age at Myopia Onset: A Study Based on a Sample of Chinese Adults.

Aim: To investigate the influence of early-life factors (Season of birth, premature birth and breastfeeding) on the age at myopia onset.

Methods: A total of 331 myopic students aged 18 years or above were recruited from one medical university in Wenzhou, China. Questionnaires were administered to collect data on age at myopia onset, early-life factors, and vision hygiene habits.

Alkaline-Assisted Excessive Impregnation for Enhancing Au Nanoparticle Loading on the TS-1 Zeolite.

Direct epoxidation of propylene (CH) with hydrogen (H) and oxygen (O) over the Au/TS-1 catalyst is known as the "Holy Grail" reaction for propylene oxide (PO) synthesis. However, Au nanoparticle loading on TS-1 was limited by traditional deposition precipitation, impregnation and could not achieve ideal catalytic results. In this report, alkaline-assisted excessive impregnation helped to remove Cl from the Au impregnation precursor, improve the loading efficiency of Au nanoparticles and overcome the abnormal growth of nanograins.

Engineering Zn/Fe Mixed Metal Oxides with Tunable Structural and Magnetic Properties for Magnetic Particle Imaging.

Engineering magnetic nanoparticles with tunable structural properties and magnetism is critical to develop desirable magnetic particle imaging (MPI) tracers for biomedical applications. Here we present a new superparamagnetic metal oxide nanoparticle with a controllable chemical composition and magnetism for imaging tumor xenografts in living mice. Superparamagnetic Zn/Fe mixed metal oxide (ZnFe-MMO) nanoparticles are fabricated via a facile one-pot co-precipitation method in water followed by thermal decomposition with tunable Zn/Fe ratios and at various calcination temperatures.

Comparative Dosing of Adjunctive Corticosteroids Therapy for Pneumonia with ARDS in Non-HIV Immunocompromised Patients.

Background: Adjuvant corticosteroids are effective in patients with human immunodeficiency virus (HIV)-associated pneumonia (PCP) patients, but the effectiveness of adjuvant corticosteroids in non-HIV PCP remained controversial. This study aimed to evaluate the effectiveness of standard-dose compared with low-dose steroids in non-HIV PCP patients with acute respiratory distress syndrome (ARDS).

Methods: This retrospective observational study included non-HIV PCP patients with ARDS admitted to the respiratory intensive care unit (RICU) of Beijing Chao-Yang Hospital from 2015 to 2022.

Chiral Metal-Free Anti-Perovskite with Strong Chiroptical Nonlinearity.

The nonlinear chiroptical properties of chiral metal halide perovskite has attracted substantial attention in recent years. In order to overcome the inherent limitations of metal halide, such as high costs, potential toxicity, challenges with recycling, especially the limited laser-induced damage threshold (LDT), we have successfully constructed the first chiral metal-free anti-perovskite, with the aim of utilizing it in second harmonic generation-circular dichroism (SHG-CD). Moreover, the anti-perovskite composed entirely of small organic ions typically display a more extensive transparent window, which could contribute a high LDT.