From metabolism to malignancy: the multifaceted role of PGC1α in cancer.

PGC1α, a central player in mitochondrial biology, holds a complex role in the metabolic shifts seen in cancer cells. While its dysregulation is common across major cancers, its impact varies. In some cases, downregulation promotes aerobic glycolysis and progression, whereas in others, overexpression escalates respiration and aggression.

Myocardial extracellular volume derived from contrast-enhanced chest computed tomography in longitudinal evaluation of cardiac toxicity in patients treated with immune checkpoint inhibitors.

Background: The immune-related adverse effects after immune checkpoint inhibitors (ICIs) treatment have always been a hot topic. Although the incidence of myocarditis is not high among the related adverse effects, the mortality rate is extremely high once it occurs. In the past, the risk of cancer therapy-related cardiac dysfunction (CTRCD) after drug treatment was evaluated based on imaging examinations, but this evaluation still had certain limitations.

Clinical significance and changes to the immune microenvironment of colorectal cancer patients with liver metastasis.

Background: Liver metastasis is common in colorectal cancer patients. Immunotherapy covers a wide range of tumor types and is safer than traditional radiotherapy and chemotherapy. However, its overall effective rate is only 20-40%.

Effect of a modified regimen on drug-sensitive retreated pulmonary tuberculosis: A multicenter study in China.

Background And Objective: Retreatment pulmonary tuberculosis (PTB) still accounts for a large proportion of tuberculosis, and the treatment outcome is unfavorable. The recurrence of retreatment PTB based on long-term follow-up has not been well demonstrated. This study aimed to evaluate effect of a modified regimen on drug-sensitive retreated pulmonary tuberculosis.

Sophoradiol inhibits the growth of drug resistant Mycobacterium tuberculosis in vitro and murine models of tuberculosis.

Tuberculosis is a devastating disease responsible for approximately 1.5 million deaths annually especially in developing countries. Although there is recommended and standard treatment for tuberculosis but the non-adherence of the patients to the lengthy treatment, adverse effects of the drugs and the emergence of multi-drug resistant strains hurdles the management of this devastating disease.

Characterization of underwater scattering layers based on variance components of LiDAR backscattering.

Range-resolved detection of submerged scattering layers was investigated in the Gulf of Mexico based on vertical profiles made with a LiDAR (Light detection and range) system having a green laser (wavelength λ = 532 nm). The backscattering power (S) variability was decomposed in principal components (PCs) and related to non-polarized S, the S ratio between cross- and co-polarized waveforms, the chlorophyll-a fluorescence (Fchl), and the ratio between volume scattering angles of 150° and 100°. The variance of PCs was dominated by non-polarized S followed by Fchl.

Omega-6 fatty acids down-regulate matrix metalloproteinase expression in a coronary heart disease-induced rat model.

The present study investigated the therapeutic potential of omega-6 fatty acids, according to their effects on antioxidant markers and matrix metalloproteinases (MMPs), in coronary heart disease-induced rats. Rats were grouped into group I (sham control), group II (control), group III (0.5 g/kg bwt of omega-6 fatty acids) and group IV (1 g/kg bwt of omega-6 fatty acids).

Chinese Herbal Medicine Baoyuan Jiedu Decoction Inhibited Muscle Atrophy of Cancer Cachexia through Atrogin-l and MuRF-1.

The aim of this study is to investigate the mechanisms of Chinese herbal medicine called "Baoyuan Jiedu" (BYJD for short) decoction, improving life quality and preventing muscle atrophy of cancer cachexia model mice. We showed that the effect of BYJD decoction increased body weights of mice and reduced tumor volume and tumor mass. Furthermore, BYJD decoction increased the gastrocnemii mass and the transverse diameter of muscle fiber morphology.

Weibull approximation of LiDAR waveforms for estimating the beam attenuation coefficient.

Tank experiments were performed at different water turbidities to examine relationships between the beam attenuation coefficient (c) and Weibull shape parameters derived from LiDAR waveforms measured with the Fine Structure Underwater LiDAR (FSUIL). Optical inversions were made at 532 nm, within a c range of 0.045-1.

Experimental study of a compressive line sensing imaging system in a turbulent environment.

Turbulence poses challenges in many atmospheric and underwater surveillance applications. The compressive line sensing (CLS) active imaging scheme has been demonstrated in simulations and test tank experiments to be effective in scattering media such as turbid coastal water, fog, and mist. The CLS sensing model adopts the distributed compressive sensing theoretical framework that exploits both intrasignal sparsity and the highly correlated nature of adjacent areas in a natural scene.

Wenxia Changfu Formula () induces apoptosis of lung adenocarcinoma in a transplanted tumor model of drug-resistance nude mice.

Objective: To explore the apoptosis mechanism of Wenxia Changfu Formula (, WCF) in reversing drug resistance of lung cancer in vivo.

Methods: Thirty model mice were randomly assigned to three groups: control group, cisplatin (CDDP) group, and WCF group. A transplanted tumor model of lung adenocarcinoma was established in all groups.

Decay dynamics of α,β-carboxylic methyl esters (CH3OCOCH:CHR) in the lower-lying excited states--resonance Raman and complete active space self-consistent field calculation study.

The photophysics of two α,β-carboxylic methyl esters after excitation to the light absorbing S2(ππ(*)) state were studied by using the resonance Raman spectroscopy and complete active space self-consistent field (CASSCF) method calculations. The vibrational spectra were assigned on the basis of the experimental measurements and the B3LYP/6-31G(d) computations, as well as the normal mode analysis. The A-band resonance Raman spectra of methyl 2,4-pentadienoate (M24PDA) and methyl trans cronoate (MTCA) were measured to probe the structural dynamics in Franck-Condon region.

Structural dynamics of phenylisothiocyanate in the light-absorbing excited states: resonance Raman and complete active space self-consistent field calculation study.

The excited state structural dynamics of phenyl isothiocyanate (PITC) after excitation to the light absorbing S2(A'), S6(A'), and S7(A') excited states were studied by using the resonance Raman spectroscopy and complete active space self-consistent field method calculations. The UV absorption bands of PITC were assigned. The vibrational assignments were done on the basis of the Fourier transform (FT)-Raman and FT-infrared measurements, the density-functional theory computations, and the normal mode analysis.

Imaging characteristics of primary intracranial teratoma.

Background: Primary intracranial teratomas are rare intracranial neoplasms, and are subdivided into mature, immature, and those with malignant transformation. To date, only a few studies of teratoma imaging have been reported.

Purpose: To describe and characterize the magnetic resonance imaging (MRI) findings in a series of 18 patients (16 men/boys and 2 women/girls; mean age, 14.

In vitro and in vivo inhibitory effect of the combination of Wenxia Changfu formula [see text] with cisplatin in non-small cell lung cancer.

Objective: To observe the effect of the combination of Wenxia Changfu Formula ([see text], WCF) with cisplatin (CDDP) on inhibiting non-small cell lung cancer (NSCLC) in vitro and In Vivo and explore its mechanism from its effect on cell cycle.

Methods: In vitro, WCF-containing serum was prepared and the rhubarb b1, emodin, and aconitine were detected qualitatively by high-performance liquid chromatogram (HPLC). A549 cell lines were treated with blank control (dimethyl sulfoxide), normal serum, normal serum with CDDP (1.

[Surveillance on Keshan disease from 1990 to 2008 in Sichuan province].

Objective: To study the epidemiological characteristics of Keshan disease (KD) and its trend so as to provide evidences for further research, prevention and treatment of the disease in Sichuan province.

Methods: Based on KD related data from 1990 to 2008, descriptive method was used to analyze the epidemiological characteristics of KD.

Results: 87 KD cases were identified during the 19 years.