[Preoperative Lymphocyte-to-monocyte Ratio Predicts Prognosis in Patients with Stage T1 Non-muscle Invasive Bladder Cancer].

Objective To investigate the clinical value of preoperative lymphocyte-to-monocyte ratio(LMR)in evaluating the prognosis of patients with stage T1 non-muscle invasive bladder cancer(NMIBC).Methods A total of 215 patients with stage T1 NMIBC who underwent transurethral resection of bladder tumor were enrolled.Clinical data were collected.

Clinicopathologic Comparison of Urothelial Bladder Carcinoma in Young and Elder Patients.

Bladder cancer (BC) is a common aggressive malignancy and Urothelial bladder cancer (UBC) consists of the majority of BC. There is uncertainty regarding the clinicopathologic characteristics of UBCs in younger patients. To investigate the clinicopathologic features of young patients with UBCs.

Fluorescent "turn-on" detecting CN(-) by nucleophilic addition induced Schiff-base hydrolysis.

A new chemosensor Sz based on Schiff-base group as recognition site and naphthalene as the fluorescence signal group was designed and synthesised. It could fluorescent "turn-on" detect cyanide (CN(-)) via a novel mechanism of nucleophilic addition induced Schiff-base hydrolysis. Adding the CN(-) into the solution of Sz could induce Sz to emit blue fluorescence at 435 nm instantly.

Serum CA 19-9 as a good prognostic biomarker in patients with bladder cancer.

Background: Bladder cancer (BC) is the second leading malignant tumors of the genitourinary system. CA 19-9 has served as a diagnostic and prognostic marker for pancreatic carcinoma for years. In recent year, although a few studies have evaluated the roles of CA 19-9 in BC, the results are conflicting and the number of the patients studied is very small.

A highly selective fluorescent chemosensor for iron ion based on 1H-imidazo [4,5-b] phenazine derivative.

Two kinds of fluorescent sensors (S and S1) for Fe(3+) bearing 1H-Imidazo [4,5-b] phenazine derivatives have been designed and synthesized. Between the two sensors, S showed excellent fluorescent specific selectivity and high sensitivity for Fe(3+) in DMSO solution. The test strip based on S was fabricated, which could act as a convenient and efficient Fe(3+) test kit.

[Clinical character of metanephric adenoma of the kidney: a case report].

To investigate the clinicopathological characteristics of metanephric adenoma (MA), we analyzed the clinical and pathological data of metanephric adenoma. A 39-year old woman with asymptomatic right kidney tumor for 4 years was admitted to the hospital. A tumor with the largest diameter of 28 mm in the right kidney was homogeneously enhanced on CT.

Highly selective fluorescent sensing for CN- in water: utilization of the supramolecular self-assembly.

A simple 4-amino-3-hydroxynaphthalene-1-sulfonic acid is demonstrated to fluorescently sense CN(-) in water based on the mechanism of supramolecular self-assembly. This work provides a novel approach for the selective recognition of CN(-) anions. The detection limit of the sensor towards CN(-) is 3.

Simultaneous renal clear cell carcinoma and gastrointestinal stromal tumor in one case.

Renal cell carcinoma is a tumor in kidney, while gastrointestinal stromal tumors are localized in the stomach and small intestine. They seldom occur simultaneously in sporadic case, both of which were suspective to sunitinib, a tyrosine kinases (RTKs) inhibitor. Our current case is novel in that concurrent RTK-related tumors are involved in one case.

Evaluation of retroperitoneoscopic partial nephrectomy with in situ hypothermic perfusion.

Background: The objective of this study was to evaluate the clinical application value of in situ hypothermic perfusion of kidneys during retroperitoneal laparoscopic partial nephrectomy (RLPN).

Methods: We used in situ hypothermic perfusion of kidneys during RLPN in 12 patients with renal tumour. Renal arterial-catheterisation for temporary balloon occlusion of renal artery was used Hypothermic ischaemia was achieved by continuous perfusion of Ringer's solution at 4°C through the renal artery.

[Application of adrenocorticotropic hormone receptor determination and ultrastructural observation of tumor cells in the subtyping of adrenocortical neoplasms].

Objective: To explore the values of adrenocorticotropic hormone receptor (ACTH-R) determination and ultrastructural observation of tumor cells in the subtyping of adrenocortical neoplasms (ANs).

Methods: The expression of ACTH-R in 87 AN tissues were determined with Polymer immunohistochemical staining, with 10 normal adrenal tissues as the controls. The ultrastructure of the tumor cells was observed using electron microscopy.

Diagnosis and treatment of primary adult renal sarcoma.

Objective: To investigate the clinical characteristics of primary adult renal sarcoma.

Methods: A total of 1654 cases with adult renal tumors were treated during 1985 to 2009 in Peking Union Medical College Hospital. Of all, 17 cases were diagnosed as primary renal sarcoma and underwent radical nephrectomy.

[Expressions of receptor tyrosine kinases mRNA and protein in carcinoma of bladder].

Objective: To detect the expressions of receptor tyrosine kinases (RTKs) mRNA and protein and to explore potentially promising tumor markers and conceivable drug target in bladder cancer.

Methods: The expressions of RTKs mRNA and protein in tissue from invasive urothelial carcinoma of the bladder were examined by real-time quantitative PCR array and cytokine antibody array, with normal bladder tissue as control. The Results were analyzed using bioinformatic approaches.

A decade of clinical experience with extra-adrenal paragangliomas of retroperitoneum: Report of 67 cases and a literature review.

Object: The purpose was to highlight the diagnosis and treatment of extra-adrenal para-gangliomas, which often causes catecholamine hypersecretion and hypertension.

Methods: 67 cases of extra-adrenal paraganglioma of retroperitoneum proven pathologically from 1999 to 2009 were reviewed and studied after operation. Endocrine secretion examinations, B-US, CT, MRI, 131-MIBG, octreotide and hands microcirculation inspection were used to diagnose the disease.

Differential diagnosis and laparoscopic treatment of adrenal pheochromocytoma and ganglioneuroma.

Background: Adrenal ganglioneuroma is a rare adrenal pathogenic disease with difficult differential diagnosis from adrenal pheochromocytoma. Currently, very limited literature is available to allow a differential diagnosis of these two conditions from each other. This study aimed to evaluate the clinical profile, differential diagnosis and surgical treatments of both conditions.

[Effects of docetaxel and prednisone for hormone-refractory prostate cancer].

Objective: To investigate the role and side effects of docetaxel and prednisone on treating hormone-refractory prostate cancer (HRPC).

Methods: Docetaxel (75 mg/m(2)) and prednisone (5 mg, bid) were given to 14 patients, whose age range from 51 to 78 years old, of hormone-refractory prostate cancer for 3 - 8 cycles. Three-week is a chemotherapy cycle.

[Serum osteoprotegerin as a novel marker of bone metastasis in prostate cancer].

Objective: To evaluate the diagnostic usefulness of serum osteoprotegerin (OPG) in prostate cancer bone metastasis.

Methods: Serum osteoprotegerin were measured by ELISA assay in 30 healthy men, 30 patients with benign prostatic hyperplasia, 66 patients with prostate cancer including 36 without bone metastasis (30 with localized cancer, 6 with lymph node metastasis) and 30 with bone metastasis. The results associated with clinical data were calculated statistically.

[Characteristics of recurrence of T1G3 transitional cell carcinoma of bladder].

Objective: To investigate the characteristics of recurrence of T1G3 transitional cell carcinoma (TCC) of bladder.

Methods: The clinical data of 72 patients with TCC of bladder of the stage T1, 37 being of the stage T1G3 and 35 being of the stage T1G1-2, who underwent the initial treatment by transurethral resection of bladder tumor plus post-operative bladder infusion were analyzed.

Results: The first, second, third, and fourth year recurrent rates of the T1G3 group were 29.

[Surgical diagnosis and treatment of Castleman's disease].

Objective: To investigate the clinical features and treatment of the surgical tumors associated with Castleman's disease.

Methods: The clinical data of 20 patients with Castleman's disease, 6 males and 14 females, aged 39 (15-70), with the tumor size ranging from 2 cm x 3 cm to 10 cm x 9 cm, and with the tumor located in the mediastinal cavity (n = 6), retroperitoneal area (n = 2), abdominal cavity (n = 1), adrenal area (n = 1), neck and armpit (n = 2), and multi-centers (n = 2), were analyzed.

Results: Nineteen of the 20 patients underwent surgical resection of the tumor or lymph node.

[Expression of HGF and its receptor c-Met in renal cell carcinoma].

Objective: To study the clinical significance of expression of hepatic growth factor (HGF) and its receptor c-Met in renal cell cancer (RCC).

Methods: Twenty-six patients with RCC and 10 benign renal tumor patients were examined. The expression of HGF and c-Met mRNA was detected using Northern blot.

[Immunotherapy of metastatic renal cell carcinoma: report of 28 cases].

Objective: To determine the efficacy of IL-2, IFN and Furtulon in patients with metastatic renal cell carcinoma.

Methods: During the induction phase of the treatment of 28 patients, which lasted 3 months, IL-2 and IFN were administered subcutaneously three times a week at doses of 5 - 20 MU/m(2) and 6 - 9 MU/m(2), Furtulon was administered at doses of 800 - 1,200 mg daily by oral during 28 days a month.

Results: The response rate was 46.

[Clinical significance of RANTES and MIP-1 alpha in acute rejection episode in kidney transplantation].

Objective: To discuss the correlation between acute rejection episodes and expression of regulated upon activation normal T cell expressed and secreted (RANTES) and macrophage inflammatory protein-1 alpha (MIP-1 alpha) gene following kidney transplantation.

Methods: A total of 76 kidney biopsies (episode biopsy) were performed on both 57 patients with allograft dysfunction following transplantation and 19 patients without rejection, and the latter were served as controls. All acute rejections were confirmed by histological examination.