Publications by authors named "Bing'er Xu"
Introduction: Senile osteoporosis is one of the most common age-related diseases worldwide. Glucagon like peptide-2 (GLP-2), a naturally occurring gastrointestinal peptide, possesses therapeutic effects on bone loss in postmenopausal women and ovariectomized rats. However, the role of GLP-2 in senile osteoporosis and underlying mechanisms has not been explored.
View Article and Find Full Text PDFArticle Synopsis
- Older adults are highly vulnerable to acute lung injury (ALI), which involves a strong inflammatory response influenced by inflammasomes.
- Metformin has shown potential as an anti-inflammatory treatment for ALI, but its specific mechanisms are not fully understood.
- In a study using older mice, metformin reduced lung injury and associated inflammatory markers, likely by suppressing the NLRC4 inflammasome through AMPK signaling, suggesting a promising therapeutic approach for ALI.
Aims: In this study, we evaluate the effects of glucagon-like peptide 2 (GLP-2) on bone microarchitecture, bone turnover markers (BTMs) and inflammation markers in ovariectomized (OVX) rats.
Material And Methods: In total, 31 Sprague-Dawley rats were divided into the following three groups: sham (control sham-operated with vehicle, n = 7), OV (OVX with vehicle, n = 12), and GLP-2 (OVX with GLP-2, n = 12). Intervention began at the 12th week after surgery and lasted for 4 weeks.