Tubular-toxic effects of aminoglycosides and their combinations with cephalosporins.

Cephalosporins have a distinctly different effect from that of aminoglycosides on membranes of the proximal tubule of the human kidney as measured by urinary AAP concentrations. Except for a slight influence by cephacetrile, cephalosporins showed no effect on the proximal tubule. In contrast, after three days of administration, the aminoglycosides caused a cumulative increase in membrane proteins of the proximal tubule to be excreted in the urine.