The Effect of Perioperative Cimetidine Administration on Time to Colorectal Cancer Recurrence.

Background: Studies have reported that the perioperative use of cimetidine, a histamine type 2 receptor antagonist, in addition to chemotherapy in patients with lymph node-positive colorectal cancer (CRC) improves the survival.

Study Question: To determine if time to CRC recurrence could be prolonged with cimetidine.

Study Design: Cimetidine was prescribed to American Joint on Cancer Committee (AJCC) stage III CRC patients perioperatively.